Lipoic acid metabolism (WP1667)

Mycobacterium tuberculosis

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Source: [http://www.genome.jp/kegg-bin/show_pathway?mtu00785 KEGG Pathways]. The lipoic acid metabolism is a subcategory of the "Metabolism of cofactors and vitamins". The salvage pathway is not understood for Mycobacterium tuberculosis, and therefore only the biosynthesis is described here.

Authors

Allan Kuchinsky , Alex Pico , Daniela Digles , Andra Waagmeester , Denise Slenter , and Egon Willighagen

Activity

last edited

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Organisms

Mycobacterium tuberculosis

Communities

Annotations

Pathway Ontology

lipoic acid metabolic pathway fatty acid biosynthetic pathway fatty acid metabolic pathway

Participants

Label Type Compact URI Comment
Protein N6-(octanoyl)lysine Metabolite kegg.compound:C16236
Protein N6-(lipoyl)lysine Metabolite kegg.compound:C16237
Lipoyl-[acp] Metabolite kegg.compound:C16239
Octanoyl-[acp] Metabolite kegg.compound:C05752
lipA GeneProduct myco.tuber:Rv2218 Original kegg element: gene;1;mtu:Rv2218
lipB GeneProduct eccode:2.3.1.181 Original kegg element: gene;8;mtu:Rv2217

References

  1. Assembly of the covalent linkage between lipoic acid and its cognate enzymes. Zhao X, Miller JR, Jiang Y, Marletta MA, Cronan JE. Chem Biol. 2003 Dec;10(12):1293–302. PubMed Europe PMC Scholia