GLP-1 secretion from intestine to portal vein (WP5446)

Homo sapiens

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Glucagon-like peptide-1 (GLP-1) is a short protein that suppresses feeding and helps manage glucose levels in diabetes. It is encoded by the GCG gene. This pathway depicts factors in GLP-1 secretion from L cells in the intestine into the portal vein, the primary entry port of digestion products into circulation. This diagram is based on Figure 2 of https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190119/.

Authors

Eric Weitz and Egon Willighagen

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

diabetes mellitus pathway glucose homeostasis pathway

Cell Type Ontology

type L enteroendocrine cell enteroendocrine cell

Participants
Query Drugst.One

Label Type Compact URI Comment
Ca2+ Metabolite chebi:29108
PCSK1 GeneProduct ensembl:ENSG00000175426 'PC1/3' per main source
SGLT1 GeneProduct ensembl:ENSG00000100170
KATPchannel GeneProduct wikidata:Q4654794
Alpha AR GeneProduct wikidata:Q66563054 Alpha-andrenergic receptor
mAChR GeneProduct wikidata:Q410959 Muscarinic acetylcholine receptor
GPCR GeneProduct wikidata:Q38173 G protein-coupled receptor
SLC2A2 GeneProduct ensembl:ENSG00000163581 'GLUT2' per main source
GCG GeneProduct ensembl:ENSG00000115263
GNAQ GeneProduct ensembl:ENSG00000156052
G-gamma GeneProduct interpro:IPR036284
G-beta GeneProduct interpro:IPR016346
Na+channel GeneProduct wikidata:Q424960
Ca+channel GeneProduct wikidata:Q15322916
GLP-1 Protein wikidata:Q424611

References

  1. Glucagon-Like Peptide-1: Actions and Influence on Pancreatic Hormone Function. Davis EM, Sandoval DA. Compr Physiol. 2020 Mar 12;10(2):577–95. PubMed Europe PMC Scholia