Biogenic amine synthesis (WP550)

Homo sapiens

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Biogenic amines are one of two broad classes of classical neurotransmitters (the other being amino acids) and include: acetylcholine, serotonin, histamine, and the catecholamines epinephrine, norepinephrine, and dopamine. Source: http://www.whatislife.com/reader2/Metabolism/pathway/Neurotransmitter.html Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP550 CPTAC Assay Portal]

Authors

Alex Pico , Kristina Hanspers , Thomas Kelder , Martijn Van Iersel , Christine Chichester , Egon Willighagen , Chris Evelo , , Martina Summer-Kutmon , Eric Weitz , and Finterly Hu

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

biogenic amine biosynthetic pathway amine neurotransmitter metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Choline Metabolite cas:62-49-7
Epinephrine Metabolite hmdb:HMDB0000068
5-hydroxy-tryptophan Metabolite cas:4350-09-8
Acetylserotonin Metabolite cas:1210-83-9
GABA Metabolite hmdb:HMDB0000112
L-DOPA Metabolite cas:59-92-7
Histidine Metabolite cas:71-00-1
Dopamine Metabolite cas:62-31-7
Acetylcholine Metabolite cas:51-84-3
Tyrosine Metabolite cas:60-18-4
Serotonin Metabolite cas:50-67-9
Phenylalanine Metabolite cas:63-91-2
Melatonin Metabolite hmdb:HMDB0001389
Glutamate Metabolite cas:56-86-0
Tryptophan Metabolite cas:73-22-3
Norepinephrine Metabolite cas:51-41-2
Histamine Metabolite cas:51-45-6
GAD2 GeneProduct ncbigene:2572
DDC GeneProduct ncbigene:1644
TPH1 GeneProduct ncbigene:7166
HDC GeneProduct ncbigene:3067
DBH GeneProduct ncbigene:1621
TH GeneProduct ncbigene:7054
PNMT GeneProduct ncbigene:5409
ACHE GeneProduct ncbigene:43
COMT GeneProduct ncbigene:1312
PAH GeneProduct ncbigene:5053
CHAT GeneProduct ncbigene:1103
AANAT GeneProduct ncbigene:15
GAD1 GeneProduct ncbigene:2571
MAOA GeneProduct ncbigene:4128
ASMT GeneProduct ncbigene:438

References

  1. Neuroscience [Internet]. Purves D. Sinauer Associates Incorporated; 2001. 709 p. Available from: https://books.google.com/books/about/Neuroscience.html?hl=&id=t9iGQgAACAAJ OpenLibrary Worldcat