Nodal signaling pathway (WP341)

Danio rerio

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Authors

Gabby Krens , Kristina Hanspers , Nicolas DAVID , Frederic Pacho , Daniela Digles , Alex Pico , Eric Weitz , and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Danio rerio

Communities

Annotations

Pathway Ontology

Nodal signaling pathway

Participants

Label Type Compact URI Comment
acvr2a GeneProduct ncbigene:338214 Activin receptor IIA (acvr2a)
acvr2b GeneProduct ncbigene:80357 ctivin receptor IIb (acvr2b), mRNA (acvr2b)
bhik GeneProduct ncbigene:64281 Bhikhari (bhik), mRNA (bhik)
bon / mixer GeneProduct ncbigene:336263 Homeodomain transcription factor Mixer (mix) (bon)
bon / mixer GeneProduct ncbigene:492490 Homeodomain transcription factor Mixer (mix) (bon)
cat GeneProduct ncbigene:368234 Catalase (cat)
cldnd GeneProduct ncbigene:286779 Claudin-like gene, clone ZF-A89 (cldnd) - anosmin1 precursor
dlx1a GeneProduct ncbigene:30216 Dlx1 (dlx1a)
flh GeneProduct ncbigene:30260 flh: Floating head (flh), mRNA
cyc / foxa /ndr2 GeneProduct ncbigene:564119 Fork head domain protein FKD4 / Nodal related 2/ cyclops
Foxh1 / sur GeneProduct ensembl:ENSDARG00000023527 Forkhead box H1 (foxh1), mRNA (foxh1) - forkhead box H1 / schmalspur (sur)
Foxh1 / sur GeneProduct ncbigene:327135 FAST1 (fast1) (foxh1)
Foxh1 / sur GeneProduct ncbigene:337369 Forkhead box H1, mRNA (cDNA clone MGC:55221 IMAGE:2639305) (foxh1)
gata5 / fau GeneProduct ncbigene:30482
lft1 / antivin GeneProduct ncbigene:114417 Antivin (lft1)
lft2 GeneProduct ncbigene:30146 Lefty2 (lft2), mRNA (lft2)
lft2 GeneProduct ncbigene:336233 Signaling molecule lefty2 (lft2) (lft2)
lft2 GeneProduct ncbigene:393724 Lefty2 (lft2), mRNA (lft2)
men1 GeneProduct ncbigene:321622 Menin (men1 gene) (men1)
neurog1 GeneProduct ncbigene:393697 Neurogenin 1 (neurog1), mRNA (neurog1)
neurog1 GeneProduct ncbigene:58121 Neurogenin (neurog1)
neurog1 GeneProduct ncbigene:30475 Neurogenin 1, mRNA (cDNA clone MGC:76812 IMAGE:6963393) (neurog1)
neurog1 GeneProduct ncbigene:30269 Neurogenin 1, mRNA (cDNA clone MGC:76812 IMAGE:6963393) (neurog1)
ntl GeneProduct ncbigene:30399 ntl: No tail (ntl), mRNA
oep GeneProduct ncbigene:386614 One-eyed pinhead (oep), mRNA (oep)
oep GeneProduct ncbigene:30406 One-eyed pinhead short form protein (oep)
oep GeneProduct ncbigene:30346 One-eyed pinhead long form protein (oep)
smad2 GeneProduct ncbigene:324790 Smad2 protein (smad2) (smad2)
smad2 GeneProduct ncbigene:323832 Transcription factor Smad2 (smad2)
smad2 GeneProduct ncbigene:393344 MAD homolog 2 (Drosophila) (smad2), mRNA (smad2)
smad2 GeneProduct ncbigene:326879 MAD homolog 2 (Drosophila), mRNA (cDNA clone MGC:113963 IMAGE:7395088) (smad2)
smad5 GeneProduct ncbigene:415211 Mad-related protein Smad5 (smad5) (smad5)
smad5 GeneProduct ncbigene:553171 MAD homolog 5 (Drosophila) (smad5), mRNA (smad5)
smad5 GeneProduct ncbigene:393459 MAD homolog 5 (Drosophila), mRNA
smad5 GeneProduct ncbigene:58093 MAD homolog 5 (Drosophila), mRNA
sox17 GeneProduct ncbigene:30544 sox17: SRY-box containing gene 17, mRNA (cDNA clone MGC:91776
sox32 / cas GeneProduct ncbigene:116990 sox32: SRY-box containing gene 32, mRNA (cDNA clone MGC:114019
sox32 / cas GeneProduct ncbigene:664758 SRY-box containing gene 32, mRNA (cDNA clone MGC:114019 IMAGE:7450460) (sox32)
sox32 / cas GeneProduct ncbigene:322641 Sox transcription factor 226D7 (sox32)
dharma / boz GeneProduct ncbigene:30170
tbx16 / spt GeneProduct ncbigene:30264
pcdh8 / papc GeneProduct ncbigene:30456
myoD GeneProduct ncbigene:664740
lim1 / lhx1a GeneProduct ncbigene:30463
cyc / foxa /ndr2 GeneProduct ncbigene:564119
cyc / foxa /ndr2 GeneProduct ncbigene:30292
smad1 GeneProduct ncbigene:30628
smad2 GeneProduct ncbigene:30639
smad3a GeneProduct ncbigene:58092
smad3b GeneProduct ncbigene:326283
smad5 GeneProduct ncbigene:30641
ERK2 / mapk1 GeneProduct ncbigene:360144
ERK1 / mapk3 GeneProduct ncbigene:399480
axial / FOXA2 GeneProduct ncbigene:30126
p300b - Dr.162298 GeneProduct ensembl:ENSDARG00000061108
taf5l GeneProduct ncbigene:334055
p300 - Dr.161135 GeneProduct ensembl:ENSDARG00000076430
p300 - pred. GeneProduct ncbigene:327385
p300 - similar GeneProduct ncbigene:337578
p300 - similar GeneProduct ncbigene:337477
BAMBI GeneProduct ncbigene:83496
foxh1 / sur GeneProduct ncbigene:57930
junb GeneProduct ncbigene:407086
stat1 GeneProduct ncbigene:30768
stat3 GeneProduct ncbigene:30767
runx2a/cbfa1 GeneProduct ncbigene:405784
CBP / crebbp GeneProduct :GENE-050208-439
smad4 GeneProduct ncbigene:559111
smad4 GeneProduct ensembl:ENSDARG00000023527
NFkB2 GeneProduct ncbigene:415100
NFkB1 GeneProduct ncbigene:565756
skiB GeneProduct ncbigene:30113
snip1 GeneProduct ncbigene:474374
ube2d1 GeneProduct ncbigene:324015
foxg1 GeneProduct ensembl:ENSDARG00000070769 foxg1 / BF1
TGIF GeneProduct ncbigene:321756
acvr1b / TARAMA GeneProduct ncbigene:30183
MITFa GeneProduct ncbigene:30080
cdx4 GeneProduct ncbigene:30330
pax6a GeneProduct ncbigene:30567
myoD GeneProduct ncbigene:30513
vox GeneProduct ncbigene:64807
vent GeneProduct ncbigene:64810
ved GeneProduct ncbigene:368201
sqt / foxa3 / ndr1 GeneProduct ncbigene:336281
cyc / foxa / ndr2 GeneProduct ncbigene:30292
cyc / foxa / ndr2 GeneProduct ncbigene:492721
cyc / foxa / ndr2 GeneProduct ncbigene:195823
sqt / foxa3 / ndr1 GeneProduct ensembl:ENSDARG00000043673
smad7 GeneProduct ncbigene:326282
smad6a GeneProduct ncbigene:116992
runx2b/cbfa1 GeneProduct ensembl:ENSDARG00000059233
runx2b/cbfa3 GeneProduct ensembl:ENSDARG00000059233
bon / mixer GeneProduct ensembl:ENSDARG00000069252
lef1 GeneProduct ensembl:ENSDARG00000031894
tcf7/tcf1 GeneProduct ncbigene:497649
tcfl1b GeneProduct ncbigene:30556
tcfl1a GeneProduct ensembl:ENSDARG00000038159
jun GeneProduct ensembl:ENSDARG00000043531
junbl GeneProduct ncbigene:336038
lft1 / antivin GeneProduct ncbigene:327065 Signaling molecule lefty1 (lft1) (lft1)
lft1 / antivin GeneProduct ncbigene:114417
lft1 / antivin GeneProduct ncbigene:327065
lft1 / antivin GeneProduct ensembl:ENSDARG00000019920

References

  1. ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis. Krens SFG, Corredor-Adámez M, He S, Snaar-Jagalska BE, Spaink HP. BMC Genomics. 2008 Apr 28;9:196. PubMed Europe PMC Scholia