T cell modulation in pancreatic cancer (WP5078)
Homo sapiens
T cells are important effector cells in pancreatic cancer. Their function is inhibited by various cellular interactions and secreted factors in the tumor microenvironment (TME). Both immune cells and pancreatic cancer cells are able to modulate T cell activation.
Authors
Dana Mustafa , Martina Summer-Kutmon , Eric Weitz , Isabel Wassink , and Egon WillighagenActivity
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Cited In
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Organisms
Homo sapiensCommunities
Diseases PancCanNetAnnotations
Pathway Ontology
immune response pathway disease pathway pancreatic cancer pathwayCell Type Ontology
T cell malignant cell pancreatic stellate cell myeloid suppressor cell CD8-positive, alpha-beta T cell professional antigen presenting cellDisease Ontology
pancreatic cancer| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Adenosine | Metabolite | chebi:16335 | |
| Adenine | Metabolite | chebi:16708 | |
| Urea | Metabolite | chebi:16199 | |
| L-ornithine | Metabolite | chebi:15729 | |
| L-arginine | Metabolite | chebi:29016 | |
| PGE2 | Metabolite | chebi:15551 | |
| D-tryptophan | Metabolite | chebi:57719 | |
| Kynurenine | Metabolite | chebi:28683 | |
| L-tryptophan | Metabolite | chebi:57912 | |
| ICOS | Protein | uniprot:Q9Y6W8 | |
| CD226 | Protein | uniprot:Q15762 | |
| FASLG | Protein | uniprot:P48023 | |
| HAVCR2 | Protein | uniprot:Q8TDQ0 | |
| TRBC1 | Protein | ensembl:ENSG00000211751 | P01850 - UniProt identifier |
| IL6 | Protein | uniprot:P05231 | |
| CCL17 | Protein | uniprot:Q92583 | |
| LGALS9 | Protein | uniprot:O00182 | |
| B2M | Protein | uniprot:P61769 | |
| FAS | Protein | uniprot:P25445 | |
| CXCL12 | Protein | uniprot:P48061 | |
| ARG1 | Protein | uniprot:P05089 | |
| PVR | Protein | uniprot:P15151 | |
| CCL22 | Protein | uniprot:O00626 | |
| TNFRSF4 | Protein | uniprot:P43489 | |
| VSIR | Protein | uniprot:Q9H7M9 | |
| TIGIT | Protein | uniprot:Q495A1 | |
| CD274 | Protein | uniprot:Q9NZQ7 | |
| VEGFA | Protein | uniprot:P15692 | |
| VEGFC | Protein | uniprot:P49767 | |
| FAP | Protein | uniprot:Q12884 | |
| VTCN1 | Protein | uniprot:Q7Z7D3 | |
| CD276 | Protein | uniprot:Q5ZPR3 | |
| CD40 | Protein | uniprot:P25942 | |
| IL10 | Protein | uniprot:P22301 | |
| LGALS3 | Protein | uniprot:P17931 | |
| TNFRSF9 | Protein | uniprot:Q07011 | |
| PDCD1 | Protein | uniprot:Q15116 | |
| HLA-A | Protein | uniprot:P04439 | |
| LGALS1 | Protein | uniprot:P09382 | |
| TRAC | Protein | ensembl:ENSG00000277734 | P01848 - UniProt identifier |
| PGF | Protein | uniprot:P49763 | |
| TGFB1 | Protein | ensembl:ENSG00000105329 | P01137 - UniProt identifier |
| TGFB3 | Protein | uniprot:P10600 | |
| IDO1 | Protein | uniprot:P14902 | |
| CD40LG | Protein | uniprot:P29965 | |
| CD28 | Protein | uniprot:P10747 | |
| TGFB2 | Protein | uniprot:P61812 | |
| VEGFD | Protein | uniprot:O43915 | |
| CTLA4 | Protein | uniprot:P16410 | |
| VEGFB | Protein | uniprot:P49765 | |
| CD86 | Protein | uniprot:P42081 | |
| PDCD1LG2 | Protein | uniprot:Q9BQ51 | |
| CD80 | Protein | uniprot:P33681 | |
| TNFSF9 | Protein | uniprot:P41273 | |
| TNFSF4 | Protein | uniprot:P23510 | |
| ENTPD1 | Protein | uniprot:P49961 | |
| NT5E | Protein | uniprot:P21589 |
References
- Role of the immune system in pancreatic cancer progression and immune modulating treatment strategies. Sideras K, Braat H, Kwekkeboom J, van Eijck CH, Peppelenbosch MP, Sleijfer S, et al. Cancer Treat Rev. 2014 May;40(4):513–22. PubMed Europe PMC Scholia
- Metabolic Interactions in the Tumor Microenvironment. Lyssiotis CA, Kimmelman AC. Trends Cell Biol. 2017 Nov;27(11):863–75. PubMed Europe PMC Scholia
- Functions of pancreatic stellate cell-derived soluble factors in the microenvironment of pancreatic ductal carcinoma. Wu Q, Tian Y, Zhang J, Zhang H, Gu F, Lu Y, et al. Oncotarget. 2017 Oct 19;8(60):102721–38. PubMed Europe PMC Scholia
- Tumor microenvironment participates in metastasis of pancreatic cancer. Ren B, Cui M, Yang G, Wang H, Feng M, You L, et al. Mol Cancer. 2018 Jul 30;17(1):108. PubMed Europe PMC Scholia
- The reciprocal regulation between host tissue and immune cells in pancreatic ductal adenocarcinoma: new insights and therapeutic implications. Liu X, Xu J, Zhang B, Liu J, Liang C, Meng Q, et al. Mol Cancer. 2019 Dec 13;18(1):184. PubMed Europe PMC Scholia
- Mechanisms of T-Cell Exhaustion in Pancreatic Cancer. Saka D, Gökalp M, Piyade B, Cevik NC, Arik Sever E, Unutmaz D, et al. Cancers (Basel). 2020 Aug 14;12(8):2274. PubMed Europe PMC Scholia
- Prognostic significance and therapeutic potential of the immune checkpoint VISTA in pancreatic cancer. Hou Z, Pan Y, Fei Q, Lin Y, Zhou Y, Liu Y, et al. J Cancer Res Clin Oncol. 2021 Feb;147(2):517–31. PubMed Europe PMC Scholia
- Arginine metabolism: a potential target in pancreatic cancer therapy. Yang JS, Wang CC, Qiu JD, Ren B, You L. Chin Med J (Engl). 2020 Nov 4;134(1):28–37. PubMed Europe PMC Scholia
- T cells in pancreatic cancer stroma. Goulart MR, Stasinos K, Fincham REA, Delvecchio FR, Kocher HM. World J Gastroenterol. 2021 Dec 14;27(46):7956–68. PubMed Europe PMC Scholia
- Role of CD155/TIGIT in Digestive Cancers: Promising Cancer Target for Immunotherapy. Wang D, Gu Y, Yan X, Huo C, Wang G, Zhao Y, et al. Front Oncol. 2022 Mar 30;12:844260. PubMed Europe PMC Scholia
- ICOS is upregulated on T cells following radiation and agonism combined with radiation results in enhanced tumor control. Blair T, Baird J, Bambina S, Kramer G, Gostissa M, Harvey CJ, et al. Sci Rep. 2022 Sep 2;12(1):14954. PubMed Europe PMC Scholia