T cell modulation and desmoplasia in pancreatic cancer (WP5078)
Homo sapiens
Pancreatic cancer cells create a microenvironment by secreting cytokines and chemokines that recruit or activate stromal cells. This promotes desmoplasia – an accumulation of extracellular matrix that contributes to fibrosis – and immune evasion. Key players include myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), regulatory T cells (Tregs), and pancreatic stellate cells (PSCs). PSCs are the main source of extracellular matrix (ECM) deposition, and the TAM-PSC interaction enhances desmoplasia. These stromal cells help cancer cells evade immune surveillance by inhibiting CD8+ T cells through factors like IL-10, TGFβ, PD-L1, and IDO.
Authors
Dana Mustafa , Martina Summer-Kutmon , Eric Weitz , Isabel Wassink , and Egon WillighagenActivity
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Organisms
Homo sapiensCommunities
Diseases PancCanNetAnnotations
Cell Type Ontology
professional antigen presenting cell malignant cell T cell pancreatic stellate cell myeloid suppressor cell CD8-positive, alpha-beta T cellDisease Ontology
pancreatic ductal adenocarcinoma pancreatic cancerPathway Ontology
immune response pathway disease pathway pancreatic cancer pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Adenosine | Metabolite | chebi:16335 | |
| Adenine | Metabolite | chebi:16708 | |
| Urea | Metabolite | chebi:16199 | |
| L-ornithine | Metabolite | chebi:15729 | |
| L-arginine | Metabolite | chebi:29016 | |
| PGE2 | Metabolite | chebi:15551 | |
| D-tryptophan | Metabolite | chebi:57719 | |
| Kynurenine | Metabolite | chebi:28683 | |
| L-tryptophan | Metabolite | chebi:57912 | |
| PDGFA | GeneProduct | ensembl:ENSG00000197461 | P01137 - UniProt identifier |
| PDGFB | GeneProduct | ensembl:ENSG00000100311 | P01137 - UniProt identifier |
| PDGFC | GeneProduct | ensembl:ENSG00000145431 | P01137 - UniProt identifier |
| PDGFD | GeneProduct | ensembl:ENSG00000170962 | P01137 - UniProt identifier |
| SHH | GeneProduct | ensembl:ENSG00000164690 | P01137 - UniProt identifier |
| VDR | GeneProduct | ensembl:ENSG00000111424 | P01137 - UniProt identifier |
| CXCL12 | GeneProduct | ensembl:ENSG00000107562 | P01137 - UniProt identifier |
| CXCR4 | GeneProduct | ensembl:ENSG00000121966 | P01137 - UniProt identifier |
| CD226 | Protein | uniprot:Q15762 | |
| ICOS | Protein | uniprot:Q9Y6W8 | |
| FASLG | Protein | uniprot:P48023 | |
| HAVCR2 | Protein | uniprot:Q8TDQ0 | |
| TRBC1 | Protein | ensembl:ENSG00000211751 | P01850 - UniProt identifier |
| IL6 | Protein | uniprot:P05231 | |
| CCL17 | Protein | uniprot:Q92583 | |
| LGALS9 | Protein | uniprot:O00182 | |
| B2M | Protein | uniprot:P61769 | |
| FAS | Protein | uniprot:P25445 | |
| CXCL12 | Protein | uniprot:P48061 | |
| ARG1 | Protein | uniprot:P05089 | |
| PVR | Protein | uniprot:P15151 | |
| CCL22 | Protein | uniprot:O00626 | |
| TNFRSF4 | Protein | uniprot:P43489 | |
| VSIR | Protein | uniprot:Q9H7M9 | |
| TIGIT | Protein | uniprot:Q495A1 | |
| CD274 | Protein | uniprot:Q9NZQ7 | |
| VEGFA | Protein | uniprot:P15692 | |
| VEGFC | Protein | uniprot:P49767 | |
| FAP | Protein | uniprot:Q12884 | |
| VTCN1 | Protein | uniprot:Q7Z7D3 | |
| CD276 | Protein | uniprot:Q5ZPR3 | |
| CD40 | Protein | uniprot:P25942 | |
| IL10 | Protein | uniprot:P22301 | |
| LGALS3 | Protein | uniprot:P17931 | |
| TNFRSF9 | Protein | uniprot:Q07011 | |
| PDCD1 | Protein | uniprot:Q15116 | |
| HLA-A | Protein | uniprot:P04439 | |
| LGALS1 | Protein | uniprot:P09382 | |
| TRAC | Protein | ensembl:ENSG00000277734 | P01848 - UniProt identifier |
| PGF | Protein | uniprot:P49763 | |
| TGFB1 | Protein | ensembl:ENSG00000105329 | P01137 - UniProt identifier |
| TGFB3 | Protein | uniprot:P10600 | |
| IDO1 | Protein | uniprot:P14902 | |
| CD40LG | Protein | uniprot:P29965 | |
| CD28 | Protein | uniprot:P10747 | |
| TGFB2 | Protein | uniprot:P61812 | |
| VEGFD | Protein | uniprot:O43915 | |
| CTLA4 | Protein | uniprot:P16410 | |
| VEGFB | Protein | uniprot:P49765 | |
| CD86 | Protein | uniprot:P42081 | |
| PDCD1LG2 | Protein | uniprot:Q9BQ51 | |
| CD80 | Protein | uniprot:P33681 | |
| TNFSF9 | Protein | uniprot:P41273 | |
| TNFSF4 | Protein | uniprot:P23510 | |
| ENTPD1 | Protein | uniprot:P49961 | |
| NT5E | Protein | uniprot:P21589 | |
| IL4 | Protein | ensembl:ENSG00000113520 | |
| IL13 | Protein | ensembl:ENSG00000169194 |
References
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