Opioid receptor pathways (WP5093)
Homo sapiens
Opioid signaling from four receptor subtypes.
Authors
Dr. T. S. Keshava Prasad , Eric Weitz , Egon Willighagen , and Kristina HanspersActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
signaling pathway pertinent to the brain and nervous system| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Diacylglycerol | Metabolite | chebi:88364 | |
| PIK3CG | GeneProduct | ncbigene:5294 | |
| PLD2 | GeneProduct | ncbiprotein:NP_002654.3 | [Pubmed:16539674] have shown that DAMGO and DPDPE stimulate OPRM1 and OPRD1 respectively and induces activation of PLD2 in an ARF-GTP dependent manner in HEK293 cells[Pubmed:19519662] have shown that DAMGO stimulates OPRM1 and induces activation of PLD2 in HEK293 cells.[Pubmed: 19666113] have shown that DAMGO stimulates OPRM1 and induces activation of PLD2 in an ARF6 dependent manner in HEK293 cells and neuronal cells of E17 Sprague-Dawley rats. |
| NOS2 | GeneProduct | ncbigene:4843 | [Pubmed: 27226238] have shown that U50,488H stimulates OPRK1 and induces downregulation of NOS2 in aorta of hyperlipidemic rats.[Pubmed: 27226238] have shown that U50,488H stimulates OPRK1 and induces inhibition of NOS2 activity in aorta of hyperlipidemic rats. |
| PLD2 | GeneProduct | ncbiprotein:NP_002654.3 | Pubmed:16539674] have shown that DAMGO and DPDPE stimulate OPRM1 and OPRD1 respectively and induces activation of PLD2 in an ARF-GTP dependent manner in HEK293 cells |
| AKT1 | GeneProduct | ncbiprotein:NP_005154.2 | [Pubmed:9722592] have shown that DAMGO stimulates OPRM1 and induces phophorylation of AKT1 at Ser473 in a Gi/G0 coupled-PI3K dependent manner in HEK293 cells.[Pubmed:26096047] have shown that morphine stimulates OPRM1 and induces phosphorylation of AKT1 at Ser473 in HEK293 cells in a PI3K dependent manner[Pubmed:15056283] have shown that DAMGO stimulates MOR and induces PI3Kgamma mediated AKT1 phosphorylation at S473 in SHSY5Y and COS7 cells.[Pubmed:19765550] have shown morphine stimulates MOR and induces phosphorylation of AKT1 at Ser 473 in CEMx174 cells. |
| OPRM1 | GeneProduct | ncbigene:4988 | |
| GSK3B | GeneProduct | ncbiprotein:NP_002084.2 | [Pubmed:9722592] have shown that DAMGO stimulates OPRM1 and induces phosphorylation of GSK3B at Ser9 in HEK293 cells. |
| RPS6KB1 | GeneProduct | ncbiprotein:NP_003152.1 | Pubmed 9722592] have shown that DAMGO stimulates OPRM1 and induces phosphorylation of RPS6KB1 at Thr389, Thr421/Ser424 in a PI3K and FRAP/mTOR dependent manner in HEK293 cells.[Pubmed:9722592] have shown that DAMGO stimulates OPRM1 and induces activation of RPS6KB1 in HEK293 cells.[Pubmed:26096047] have shown that morphine stimulates OPRM1 and induces phosphorylation of RPS6KB1 at Thr 389 in HEK293 cells in a PI3K-AKT1-MTOR dependent manner. |
| EIF4EBP1 | GeneProduct | ncbiprotein:NP_004086.1 | [Pubmed:9722592] have shown that DAMGO stimulates OPRM1 and induces phosphorylation of EIF4EBP1 in a PI3K and FRAP/mTOR dependent manner in HEK293 cells. |
| EIF4EBP2 | GeneProduct | ncbiprotein:NP_004087.1 | [Pubmed:9722592] have shown that DAMGO stimulates OPRM1 and induces phosphorylation of EIF4EBP2 in a PI3K and FRAP/mTOR dependent manner in HEK293 cells. |
| RPS6KB1 | GeneProduct | ncbiprotein:NP_003152.1 | [Pubmed: 9224649] have shown that DADLE stimulates OPRD1 and induces activation of RPS6KB1 in a Gi/G0, PI3K and FRAP/RAFT dependent manner in D2 cells. |
| PRKCZ | GeneProduct | ncbiprotein:NP_005154.2 | [Pubmed:21250979] have shown that SNC80 and DPDPE stimulates DOR and induces phosphorylatio of PRKCZ at T410 in a PI3K dependent manner in CHO cells.[Pubmed: 19682542] have shown that Loperamide stimulates MOR and induces phosphorylation of PRKCZ at Thr 410 in myoblasts C2C12 cells. |
| PLCB3 | GeneProduct | ncbiprotein:NP_000923.1 | [Pubmed:9572309] have shown that DAMGO stimulates MOR and induces activation of PLCB3 in a Gbetagamma mediated PLCB3 activation in CHO cells.[Pubmed:19020012] have shown that morphine/DAMGO stimulates MOR and induces Gbetagamma mediated PLCB3 activation in CHO cells.[Pubmed:9572309] have shown that DPDPE, U-50,488H and DAMGO stimulate DOR, KOR, MOR respectively, and induce activation of PLCB3 in a Galpha16 dependent manner in COS-7 cells. |
| EEA1 | GeneProduct | ncbiprotein:NP_003557.3 | [Pubmed:20354103] have shown that DAMGO stimulateS OPRM1 and incudes activation of EEA1 in SH-SY5Y cells. |
| PDGFRB | GeneProduct | ncbiprotein:NP_002600.1 | [Pubmed:16918381] have shown that morphine stimulates MOR and induces phosphorylation of PDGFRB at Y716 in mouse retinal endothelial cells. |
| KDR | GeneProduct | ncbiprotein:NP_002244.1 | [Pubmed:16918381] have shown that morphine stimulates MOR and induces phosphorylation of KDR at Y1212 in mouse retinal endothelial cells. |
| CDK5 | GeneProduct | ncbiprotein:NP_004926.1 | [Pubmed:16879821] have shown that DAMGO stimulates OPRM1 and induces activation of CDK5 in SH-SY5Y cells. |
| STAT3 | GeneProduct | ncbiprotein:NP_003141.2 | [Pubmed: 16918381] have shown that morphine stimulates MOR and induces MOR/KDR mediated STAT3 phosphorylation at Y705 in mouse retinal endothelial cells[Pubmed:21801866] have shown that DALDA stimulates MOR and induces STAT3 phosphorylation at Tyr 705 in mouse colonocytes.[Pubmed:16918381] have shown that morphine stimulates MOR and induces translocation of phosphorylated STAT3 from cytosol to nucleus under the influence of MOR/KDR in mouse retinal endothelial cells.[Pubmed:16879821] have shown that DAMGO stimulates MOR and induces STAT3 phosphorylation at Ser 727 in SH-SY5Y cells. |
| PDK1 | GeneProduct | ncbiprotein:NP_001265478.1 | [Pubmed:21454526] have shown that DAMGO stimulates MOR and induces phosphorylation of PDK1 at Y373/Y376 in M13 cells |
| PRKCZ | GeneProduct | ncbiprotein:NP_002735.3 | [Pubmed:21454526] have shown that DAMGO stimulates MOR and induces phosphorylation of PDK1 at Y373/Y376 in M13 cells |
| PRKCZ | GeneProduct | ncbiprotein:NP_002735.3 | [Pubmed:21454526] have shown that DAMGO stimulates MOR and induces phosphorylation of PRKCZ at Thr 410 in a PDK1 mediated manner in CHO and M13 cells[Pubmed:21454526] has shown that DAMGO stimulates MOR and induces activation of PRKCZ in M13 cells. |
| CCR5 | GeneProduct | ncbiprotein:NP_000570.1 | [Pubmed:21454526] have shown that DAMGO stimulates MOR and induces association of CCR5 and activated PRKCZ in M13 cells |
| CCR5 | GeneProduct | ncbiprotein:NP_000570.1 | [Pubmed:21454526] have shown that DAMGO stimulates MOR and induces phosphorylation of CCR5 at S349 in a PRKCZ dependent manner in M13 cells |
| IGF1R | GeneProduct | ncbiprotein:NP_000866.1 | [Pubmed: 21515255] have shown that NDMC stimulates DOR and induces phosphorylation of IGF1R at Tyr1135/ Tyr1136 in chinese hamster cells. |
| GSK3B | GeneProduct | ncbiprotein:NP_002084.2 | [Pubmed: 21515255] have shown that NDMC stimulates DOR and induces phosphorylation of GSK3B at Ser9 in rat nuclear accumbens. |
| AKT1 | GeneProduct | ncbiprotein:NP_005154.2 | [Pubmed:21250979] have shown that SNC80 and DPDPE stimulates DOR and induces phosphorylation of AKT1 at T308 in a PI3Kalpha dependent manner in CHO cells.[Pubmed: 21515255] have shown that NDMC stimulates DOR and induces phosphorylation of AKT1 at T308 in rat nuclear accumbens.[Pubmed:16249373] have shown that DADLE stimulates DOR and induces phophorylation of AKT1 at Ser473 in a PI3K independent manner in murine splenocytes. |
| STAT3 | GeneProduct | ncbiprotein:NP_003141.2 | [Pubmed: 22033345] have shown that SNC80 stimulates DOR and induces phosphorylation of STAT3 at S727 in rat bone marrow derived mesenchymal stem cells. |
| CREB1 | GeneProduct | ncbiprotein:NP_604391.1 | [Pubmed: 23682813] have shown that morphine stimulates MOR and induces phosphorylation of CREB1 at S133 in mice striatum |
| GRIN1 | GeneProduct | ncbiprotein:NP_001172020.1 | [Pubmed:25445489] have shown that morphine stimulates MOR and induces phosphorylation of GRIN1 at S890 in male albino CD1 mice. |
| GRIN2A | GeneProduct | ncbiprotein:NP_000824.1 | [Pubmed:25445489] have shown that morphine stimulates MOR and induces phosphorylation of GRIN2A at Y1325 in male albino CD1 mice. |
| CAMK2A | GeneProduct | ncbiprotein:NP_057065.2 | [Pubmed:25445489] have shown that morphine stimulates MOR and induces phosphorylation of CAMK2A at T286 in male albino CD1 mice. |
| RAC1 | GeneProduct | ncbigene:5879 | [Pubmed: 27634008] have shown that U50488 stimulate KOR and induces the downregulation of RAC1 in mouse hippocampus |
| BDNF | GeneProduct | ncbigene:627 | [Pubmed: 27634008] have shown that U50488 stimulates KOR and induces the downregulation of BDNF in mouse Hippocampus, prefrontal cortex and primart cortical neurons |
| AKT1 | GeneProduct | ncbiprotein:NP_005154.2 | [Pubmed:23775075] have shown that U-69,593 stimulates KOR and induces the phosphorylation of AKT1 at S473 in a G alpha i/0 mediated manner in CHO-KOR cells and mice striatal neurons |
| STAT5B | GeneProduct | ncbiprotein:NP_036580.2 | [Pubmed:23906478] have shown that DSLET stimulates DOR and induces phosphorylation of STAT5B at Y699 in a G alpha i/0 dependent manner in Neuro 2A cells |
| STAT3 | GeneProduct | ncbiprotein:NP_003141.2 | [Pubmed:23996400] have shown that BRL52537 stimulates KOR and induces phosphorylation of STAT3 at Y705 in ischemia reperfused rat hippocampal CA1 region. |
| CREB1 | GeneProduct | ncbiprotein:NP_604391.1 | [Pubmed:28097228] have shown that U-50,488H stimulates KOR and induces phosphorylation of CREB1 at S133 in porcine articular chondrocytes. |
| CASP1 | GeneProduct | ncbiprotein:NP_150634.1 | [Pubmed:26162710] have shown that morphine stimulates MOR and induces cleavage induced activation of CASP1 in a PI3K/AKT mediated manner in rat spinal cord tissue. |
| IL1B | GeneProduct | ncbiprotein:3553 | [Pubmed:26162710] have shown that morphine stimulates MOR and induces upregulation of IL1B in a PI3K/AKT/CASP1 dependent manner in rat primary spinal neurons. |
| NOS1 | GeneProduct | ncbiprotein:NP_001191147.1 | [Pubmed:21348811] have shown that morphine stimulates MOR and induces phosphorylation of NOS1 at Ser 1417 activated by AKt1 cascade in mouse PAG synaptosomes. |
| RGS17 | GeneProduct | ncbiprotein:NP_036551.3 | [Pubmed:21348811] have shown that morphine stimulates MOR induces association of activated NOS1 and RGS17 in mouse PAG synaptosomes. |
| NOS1 | GeneProduct | ncbiprotein:NP_001191147.1 | [Pubmed:21348811] have shown that morphine stimulates MOR induces association of OPRM1 and NOS1 in mouse PAG synaptosomes. |
| OPRM1 | GeneProduct | ncbiprotein:NP_001138751.1 | [Pubmed:21348811] have shown that morphine stimulates MOR induces association of activated NOS1 and RGS17 in mouse PAG synaptosomes. |
| CACNA1B | GeneProduct | ncbigene:774 | [Pubmed:16311589] have shown that nociceptin stimulates ORL1 and induces translocation of OPRL1-CACNA1B complex from cell membrane to cytosol in CHO cells and rat DRG neurons. |
| PRKCG | GeneProduct | ncbiprotein:NP_001303258.1 | [Pubmed: 25806604] have shown that morphine stimulates MOR and induces phosphorylation of PRKCG at S729 in mouse spinal glial cells. |
| MAPK8 | GeneProduct | ncbiprotein:NP_001265476.1 | [Pubmed: 25806604] have shown that morphine stimulates MOR and induces phosphorylation of MAPK8 at T183 in mouse spinal glial cells. |
| MAPK9 | GeneProduct | ncbiprotein:NP_620709.1 | [Pubmed: 25806604] have shown that moprhine stimulates MOR and induces phosphorylation of MAPK9 at Y185 in mosue spinal glial cells |
| JUN | GeneProduct | ncbiprotein:NP_002219.1 | [Pubmed: 25806604] have shown that morphine stimulates MOR and induces phosphorylation of JUN at S73 in mouse spinal glial cells. |
| MAPK9 | GeneProduct | ncbiprotein:NP_620709.1 | [Pubmed:15056283] have shown that DAMGO stimulates MOR and U-50,488H stimulates KOR and induces phosphorylation of MAPK9 at Tyr185 in SHSY5Y cells and THP1 cells, respectively. |
| NFE2L2 | GeneProduct | ncbiprotein:NP_006155.2 | [Pubmed:30595095] have shown that dynorphin A stimulates OPRK1 and induces translocation of NFE2L2 from cytosol to nucleus in rat hippocampal neurons. |
| EGFR | GeneProduct | ncbiprotein:NP_005219.2 | [Pubmed:17545478] have shown that DADLE stimulates DOR and induces phosphorylation of EGFR at Tyr 1173 in isolated rabbit heart |
| JUN | GeneProduct | ncbiprotein:NP_002219.1 | [Pubmed:16249373] have shown that DADLE stimulates DOR and induces phosphorylation of JUN at Ser63 in an AKT dependent manner in mouse splenocytes. |
| AKT | GeneProduct | refseq:NP_005154.2 | [Pubmed:24654606] have shown that morphine stimulates MOR and induces phosphorylation of AKT1 at Ser473 and Thr308 in µ-SK-N-LO cells and mouse sensory DRG neurons. |
| RELA | Protein | ncbigene:5970 | [Pubmed:23402995] have shown that U50,488H stimulates OPRK1 and induces downregulation of RELA in Male Sprague Dawley rat myocardial infarction and reperfusion heart model. |
| MAP2K1 | Protein | ncbiprotein:NP_002746.1 | [Pubmed:24061856] have shown that morphine stimulates OPRM1 and induces phosphorylation of MAP2K1 in a RAF1 dependent manner in HEK293 cells |
| KRAS | Protein | ncbiprotein:NP_004976.2 | [Pubmed:24061856] have shown that morphine stimulates OPRM1 and induces activation of KRAS in HEK293 cells |
| RAF1 | Protein | ncbiprotein:NP_001341618.1 | [Pubmed:24061856] have shown that morphine stimulates OPRM1 and induces activation of RAF1 in HEK293 cells.[Pubmed:24061856] have shown that morphine stimulates OPRM1 and induces phosphorylation of RAF1 at Tyr340/341 in HEK293 cells |
| SRC | Protein | ncbiprotein:NP_005408.1 | Pubmed:24061856] have shown that morphine stimulates OPRM1 and induces phosphorylation of SRC at Tyr416 in HEK293 cells. |
| AKT1 | Protein | ncbiprotein:NP_005154.2 | [Pubmed:27226238] has shown that U50,488H stimulates OPRK1 and induces phosphorylation of AKT1 at Ser273 in human umbilical vein endothelial cell lines (HUVECs) and aorta of hyperlipidemic rat.[Pubmed:30595095] have shown that dynorphin A stimulates KOR and induces phosphorylation of AKT1 at Ser 473 in a PI3K dependent manner in rat hippocampal neurons |
| NOS3 | Protein | ncbiprotein:NP_000594.2 | [Pubmed:27226238] has shown that U50,488H stimulates OPRK1 and induces phosphorylation of NOS3 at Ser1177 in human umbilical vein endothelial cell lines (HUVECs) and aorta of hyperlipidemic rat.[Pubmed: 27226238] have shown that U50,488H stimulates OPRK1 and induces activation of NOS3 in aorta of hyperlipidemic rats. |
| OPRD1 | Protein | ncbiprotein:NP_000902.3 | [Pubmed:16539674] have shown that DPDPE stimulates OPRD1 and induces transport of OPRD1 from plasma membrane to cytosol in HEK293 cells. |
| OPRD1 | Protein | ncbiprotein:NP_000902.3 | [Pubmed:16539674] have shown that DPDPE stimulates OPRD1 and induces transport of OPRD1 from plasma membrane to cytosol in HEK293 cells.[Pubmed: 10893226] have shown that deltorphinII stimultes OPRD1 and induces transport of OPRD1 from the plasma membrane to cytosol in HEK293 cells.[Pubmed:10884553] have shown that DTLET stimulates OPRD1 and induces transport of OPRM1 from plasma membrane to cytosol in C6 cells |
| PRKCE | Protein | ncbiprotein:NP_005391.1 | [Pubmed:24113748] have shown that morphine stimulates OPRM1 and induces activation of PRKCE in HEK293 cells[Pubmed:20043990] have shown that morphine stimulates OPRM1 and induces activation of PRKCE in HEK293 cells.[Pubmed: 12750434] have shown that DAMGO stimulates MOR and ORL1 receptor induces translocation of PRKCE from cytosol to plasma membrane in SH-SY5Y cells. |
| OPRK1 | Protein | ncbiprotein:NP_001305426.1 | [Pubmed:22736766] have shown that 6'-GNTI/EKC/U50488 stimulates KOR and induces activation of OPRK1 in HEK293T cells[Pubmed: 10334841] have shown that U69,593 stimulates OPRK1 and induces activation of OPRK1 in CHO-K1 cells |
| PPP3CA | Protein | ncbiprotein:NP_000935.1 | [Pubmed:24113748] have shown that morphine stimulates MOR and induces association of FKBP1A to OPRM1 in HEK293 cells |
| FKBP1A | Protein | ncbiprotein:NP_000792.1 | [Pubmed:24113748] have shown that morphine stimulates MOR and induces association of FKBP1A to OPRM1 in HEK293 cells |
| SLC6A3 | Protein | ncbiprotein:NP_001035.1 | [Pubmed:25107591] have shown that SalA, U69,593 and U50,488 stimulates OPRK1 and induces activation of SLC6A3 in a Gi/Go and ERK1/2 dependent manner in EM4 cells[Pubmed:25107591] have shown that SalA stimulates KOR and induces upregulation of SLC6A3 protein in human EM4 cells and rat striatal synaptosomes. |
| FOS | Protein | ncbiprotein:NP_005243.1 | [Pubmed:23062312] have shown that U50,488 stimulates OPRK1 and induces activation of FOS in mice hypothalamic arcuate nucleus neurons. |
| ELK1 | Protein | ncbiprotein:NP_001107595.1 | [Pubmed: 12031654] have shown that morphine or enkaphalin stimulates OPRM1and induces phosphorylation of ELK1 at Ser383 in cord blood hematopoietic stem cells (CD34+ cells). |
| MAPK1 | Protein | ncbiprotein:NP_002736.3 | [Pubmed:9721727] have shown that Nociceptin and DAMGO stimulates OPRL1 and OPRM1 respectively and induces activation of MAPK1 in CHO-ORL1, CHO-u and COS-7 cells in a Gi/G0, PI3K and SOS activity dependent manner. |
| MAPK3 | Protein | ncbiprotein:NP_002736.3 | [Pubmed:9721727] have shown that Nociceptin and DAMGO stimulates OPRL1 and OPRM1 respectively and induces activation of MAPK3 in CHO-ORL1, CHO-u and COS-7 cells in a Gi/G0, PI3K and SOS activity dependent manner. |
| OPRD1 | Protein | ncbiprotein:NP_000902.3 | [Pubmed:24976397] have shown that DAMGO, deltorphinII and DPDPE stimulates OPRM1, OPRM1-OPRD1 heteromer and OPRD1 respectively and induces activation of GNAI3 in rat striatum and hippocampus. |
| MAPK1 | Protein | ncbiprotein:NP_002736.3 | [Pubmed:24113748] have shown that morphine stimulates OPRM1 and induces phosphorylation of MAPK1 at Thr202 in a PRKCE dependent manner in HEK293 cells.[Pubmed:15944153] have shown that DAMGO and U-69,593 stimulate MOR and KOR and induce MAPK1 phosphorylation in a PLC/CAM mediated and PI3K mediated manner, respectively in rat cortical astrocytes. |
| MAPK3 | Protein | ncbiprotein:NP_002736.3 | [Pubmed:24113748] have shown that morphine stimulates OPRM1 and induces phosphorylation of MAPK3 at Tyr204 in a PRKCE dependent manner in HEK293 cells[Pubmed:15944153] have shown that DAMGO and U-69,593 stimulate MOR and KOR and induce MAPK1 phosphorylation in a PLC/CAM mediated and PI3K mediated manner, respectively in rat cortical astrocytes. |
| OPRL1 | Protein | ncbiprotein:NP_001305782.1 | [Pubmed: 10334841] have shown that Nociceptin stimulates OPRL1 and induces activation of OPRL1 in CHO-K1 cells |
| MAPK1 | Protein | ncbiprotein:NP_002736.3 | [Pubmed:10884553] have shown that morphine stimulates OPRM1 and OPRD1; DAMGO and DTLET stimulates OPRM1 and OPRD1 respectively and induces phosphorylation of MAPK1 in CHO and C6 cells[Pubmed:10884553] have shown that DTLET and DAMGO stimulate OPRD1 and OPRM1 respectively and induces activation of MAPK1 in CHO cells.[Pubmed: 12031654] have shown that morphine or enkaphalin stimulates OPRM1 and induces phosphorylation of MAPK1 at Thr185/Y187 in cord blood hematopoietic stem cells (CD34+ cells)Pubmed: 12031654] have shown that morphine or enkaphalin stimulates OPRM1 and induces activation of MAPK1 in cord blood hematopoietic stem cells (CD34+ cells).[Pubmed:10452557] have shown that morphine and endomorphine-1 stimulate OPRM1 and induces the activation MAPK1 in a PI3K, PTK and PKC dependent manner in CHO- K1 cells |
| MAPK3 | Protein | ncbiprotein:NP_002736.3 | Pubmed:10884553] have shown that morphine stimulates OPRM1 and OPRD1; DTLET and DAMGO stimulates OPRD1 and OPRM1 respectively and induces phosphorylation of MAPK3 in CHO and C6 cells[Pubmed:10884553] have shown that DTLET and DAMGO stimulate OPRD1 and OPRM1 respectively and induces activation of MAPK3 in CHO cells.[Pubmed: 12031654] have shown that morphine or enkaphalin stimulates OPRM1 and induces phosphorylation of MAPK3 at Thr202/Y204 in cord blood hematopoietic stem cells (CD34+ cells)Pubmed: 12031654] have shown that morphine or enkaphalin stimulates OPRM1 and induces activation of MAPK3 in cord blood hematopoietic stem cells (CD34+ cells).[Pubmed:10452557] have shown that morphine and endomorphine-1 stimulate OPRM1 and induces the activation MAPK1 in a PI3K, PTK and PKC dependent manner in CHO- K1 cells |
| MAPK1 | Protein | ncbiprotein:NP_002736.3 | [Pubmed:9224649] have shown that DADLE stimulates OPRD1 and induces activation of MAPK1 in a PI3K independent manner in rat D2 cells. |
| MAPK3 | Protein | ncbiprotein:NP_002736.3 | [Pubmed:9224649] have shown that DADLE stimulates OPRD1 and induces activation of MAPK3 in a PI3K independent manner in rat D2 cells. |
| TNF | Protein | ncbigene:7124 | [Pubmed:23402995] have shown taht U50,488H stimulates OPRK1 and induces downregulation of TNF in Male Sprague Dawley rat myocardial infarction and reperfusion heart model.[Pubmed:22806643] have shown that DAMGO stimulates OPRM1 and induces downregulation of TNF in ischemia and reperfusion heart model of mice. |
| MTOR | Protein | ncbiprotein:NP_004949.1 | [Pubmed:26096047] have shown that morphine stimulates OPRM1 and induces phosphorylation of MTOR at Ser2448 in HEK293 cells ina PI3K-AKT1 dependent manner. |
| GPX1 | Protein | ncbiprotein:NP_000572.2 | [Pubmed:19709398] have shown that DADLE stimulates OPRD1 and induces increased activation of GPX1 in ischemia and reperfusion brain model of rats. |
| CASP3 | Protein | ncbiprotein:836 | [Pubmed:19709398] have shown that DADLE stimulates OPRD1 and induces downregulation of CASP3 in cerebral ischemia and reperfusion brain model of rat. |
| TLR4 | Protein | ncbigene:7099 | [Pubmed:23402995] have shown that U50,488H stimulates OPRK1 and induces downregulation of TLR4 in Male Sprague Dawley rat's myocardial infarction and reperfusion heart model. |
| ADCY5 | Protein | ncbiprotein:NP_000792.1 | [Pubmed:24061856] have shown that morphine stimulates MOR and induces association of OPRM1 and ADCY5 in HEK293 cells |
| ADCY6 | Protein | ncbiprotein:NP_000792.1 | [Pubmed:24061856] have shown that morphine stimulates MOR and induces association of OPRM1 and ADCY6 in HEK293 cells |
| SRC | Protein | ncbiprotein:NP_005408.1 | [Pubmed:21250979] have shown that SNC80 and DPDPE stimulates DOR and induces phosphorylation of SRC at Y416 in a Gi/G0 dependent manner in CHO cells. |
| MAPK1 | Protein | ncbiprotein:NP_002736.3 | [Pubmed:21250979] has shown that SNC80 and DPDPE stimulates DOR and induces phosphorylation of MAPK1 in CHO cells. |
| MAPK3 | Protein | ncbiprotein:NP_002736.3 | [Pubmed:21250979] has shown that SNC80 and DPDPE stimulates DOR and induces phosphorylation of MAPK3 in CHO cells. |
| MAPK8 | Protein | ncbiprotein:NP_001265476.1 | [Pubmed:15056283] have shown that U-50,488H stimulates KOR and induces phosphorylation of MAPK8 at T183 in THP1 cells.[Pubmed:26297384] have shown that salvinorin A stimulates KOR and induces phosphorylation of MAPK8 in rat peripheral sensory neurons.[Pubmed:15056283] have shown that DAMGO stimulates MOR and U-50,488H stimulates KOR and induces activation of MAPK8 in SHSY5Y cells and THP1 cells, respectively. |
| MAPK8 | Protein | ncbiprotein:NP_001265476.1 | [Pubmed:15056283] have shown that DAMGO stimulates MOR and U-50,488H stimulates KOR and induces activation of MAPK8 in SHSY5Y cells and THP1 cells, respectively. |
| RAC1 | Protein | ncbiprotein:NP_061485.1 | [Pubmed:15056283] have shown that DAMGO stimulates MOR and induces activation of RAC1 in SHSY5Y and COS7 cells. |
| CDC42 | Protein | ncbiprotein:NP_001034891.1 | [Pubmed:15056283] have shown that DAMGO stimulates MOR and induces activation of CDC42 in SHSY5Y and COS7 cells.[Pubmed:14996948] have shown that U-50,488H stimulates OPRK1 and induces activation of CDC42 in a Gbetagamma/SRC-FAK dependent manner in THP1 cells. |
| OPRD1 | Protein | ncbiprotein:NP_000902.3 | [Pubmed:10334841] have shown that DPDPE stimulates OPRD1 and induces activation of OPRD1 in CHO-K1 cells[Pubmed:10893226] have shown that deltorphinII stimulates OPRD1 and induces phosphorylation at Ser363 in OPRD1 in HEK293 cells.[Pubmed:10884553] have shown that DTLET stimulates OPRD1 and induces transport of OPRD1 from cell membrane to cytosol in CHO delta OR cells.[Pubmed:18463167] have shown that DPDPE stimulates OPRD1 and induces transport of OPRD1 from plasma membrane to cytosol in HEK293 cells[Pubmed:21422164] have shown that DPDPE stimulates OPRD1 induces transport from plasma membrane to cytosol in HEK293 cells. |
| SOD1 | Protein | ncbiprotein:NP_000445.1 | [Pubmed:19709398] have shown that DADLE stimulates OPRD1 and induces increased activation of SOD1 in ischemia and reperfusion brain model of rats. |
| PTK2 | Protein | ncbiprotein:NP_001339623.1 | [Pubmed:14996948] have shown that U-50,488H stimulates OPRK1 and induces phosphorylation of PTK2 at Y397 in THP1 and COS7 cells. |
| SRC | Protein | ncbiprotein:NP_005408.1 | [Pubmed:14996948] have shown that U-50,488H stimulates OPRK1 and induces phosphorylation of SRC at Y416 in THP1 and COS7 cells |
| MAPK14 | Protein | ncbiprotein:NP_001306.1 | [Pubmed:23965172] have shown loperamide/fentanyl/methadone/beta-endorphin/morphine stimulate OPRM1 and induce phosphorylation of MAPK14 at T180/Y182 in human T-lymphocytes[Pubmed:20354103] have shown that DAMGO and DPDPE stimulate OPRM1 and OPRD1 respectively, and incudes activation of MAPK14 in SHSY-5Y cells.[Pubmed: 12031654] have shown that morphine or enkephalin stimulate MOR and induce phosphorylation of MAPK14 at Thr 180/Tyr 182 in cord blood hematopoietic stem cells (CD34+ cells) |
| CDK5R1 | Protein | ncbiprotein:8851 | [Pubmed:16879821] have shown that DAMGO stimulates OPRM1 and induces upregulation of CDK5R1 in SH-SY5Y cells and rat embryonic hippocampal neurons. |
| MAPK1 | Protein | ncbiprotein:NP_002736.3 | [Pubmed:17384143] have shown that deltorphin II stimulates OPRM1-OPRD1 heterodimer to induce beta arrestin 2 mediated MAPK1 phosphorylation in SKNSH cells.[Pubmed:17384143] have shown that DAMGO stimulates OPRM1 and induces PKC mediated MAPK1 phosphorylation in CHO cells[Pubmed:23965172] have shown that fentanyl/loperamide/morphine/beta-endorphin/methadone stimulate OPRM1 and induces phosphorylation of MAPK1 in human T-lymphocytes.[Pubmed: 15647486] have shown that morphine stimulates MOR induces phosphorylation of MAPK1 at Thr 185/Tyr 187 in mouse microglial EOC2 cells.[Pubmed:31347026] have shown that morphine stimulates MOR and induces phosphorylation of MAPK1 at Thr 185/Tyr 187 under NOTCH1 in mouse spinal cord. |
| MAPK3 | Protein | ncbiprotein:NP_002736.3 | [Pubmed:17384143] have shown that DAMGO stimulates OPRM1-OPRD1 heterodimer to induce beta arrestin 2 mediated MAPK13 phosphorylation in SKNSH cells.[Pubmed:23965172] have shown that fentanyl/loperamide/morphine/beta-endorphin/methadone stimulate OPRM1 and induces phosphorylation of MAPK3 in human T-lymphocytes.[Pubmed:17384143] have shown that DAMGO stimulates OPRM1 and induces PKC mediated MAPK3 phosphorylation in CHO cells[Pubmed: 15647486] have shown that morphine stimulates MOR and induces phosphorylation of MAPK3 at Thr 202/Tyr 204 in mouse microglial EOC2 cells[Pubmed:31347026] have shown that morphine stimulates MOR and induces phosphorylation of MAPK3 at Thr 202/Tyr 204 under NOTCH1 in mouse spinal cord. |
| RPS6KA1 | Protein | ncbiprotein:NP_002944.2 | [Pubmed:17384143] have shown that DAMGO stimulates OPRM1 and OPRM1-OPRD1 heteromer and induces MAPK1/3 mediated phosphorylation of RPS6KA1 at T359/S363 in CHO cells. |
| GNAI2 | Protein | ncbiprotein:NP_002061.1 | [Pubmed: 20043990] have shown that morphine stimulates MOR and induces phosphorylation of GNAI2 at S44/S144/S302 by PRKCE in HEK293 cells. |
| MBP | Protein | ncbiprotein:4155 | [Pubmed:22002899] have shown that methadone/Buprenorphine stimulates MOR and induces upregulation of MBP in rat oligodendrocytes. |
| MAPK9 | Protein | ncbiprotein:NP_002743.3 | [Pubmed:26056051] have shown that morphine and fentanyl stimulate OPRM1 and induce activation of MAPK9 in a Src-PKC dependent and GRK3-ARBB2, Src dependent manner respectively in C57Bl/6 mice |
| OPRK1 | Protein | ncbiprotein:NP_001305426.1 | [Pubmed:22736766] have shown that EKC/U50,488 stimulates KOR and induces association of OPRK1 and ARR3 in HEK293 cells |
| ARR3 | Protein | ncbiprotein:NP_004303.2 | [Pubmed:22736766] have shown that EKC/U50488 stimulates KOR and induces association of OPRK1 and ARR3 in HEK293 cells |
| OPRK1 | Protein | ncbiprotein:NP_001305426.1 | [Pubmed:22736766] have shown that EKC/U50488 stimulates KOR and induces translocation of OPRK1 from plasma membrane to cytoplasm in HEK293T cells. |
| OPRK1 | Protein | ncbiprotein:NP_001305426.1 | [Pubmed:22736766] have shown that EKC/U50488 stimulates KOR and induces translocation of OPRK1 from plasma membrane to cytoplasm in HEK293T cells.[Pubmed:23775075] have shown that U-69,593 stimulates KOR and induces translocation of OPRK1 from plasma membrane to endosomein CHHO-KOR cells and mice striatal neurons. |
| RGS9 | Protein | ncbigene:8787 | [Pubmed:24561386] have shown that morphine stimulates MOR and induces downregulation of RGS9 in mouse D2-type neurons. |
| MAPK14 | Protein | ncbiprotein:NP_001306.1 | [Pubmed:25857454] has shown that dynorphin stimulates KOR induce phosphorylation of MAPK14 in Chinese Hamster Ovary cell line. |
| ARRB2 | Protein | ncbiprotein:NP_001244257.1 | [Pubmed:25857454] have shown that dynorphin stimulates OPRK1 and induces translocation of ARBB2 from cytosol to plasma membrane in CHO cells. |
| CREB1 | Protein | ncbiprotein:NP_604391.1 | [Pubmed: 10708700] have shown that morphine and DPDPE stimulates DOR induce phosphorylation of CREB1 at Ser133 in NG108-15 cells |
| MAPK1 | Protein | ncbiprotein:NP_002736.3 | [Pubmed: 10646507] have shown that U69,593 stimulates of OPRK1 induces phosphorylation of MAPK1 at Thr185/Tyr187 in C6 glioma cells in a Gβγ subunits and Ras dependent manner |
| MAPK3 | Protein | ncbiprotein:NP_002736.3 | [Pubmed: 10646507] have shown that U69,593 stimulates KOR induces phosphorylation of MAPK3 at Thr202/Tyr204 in C6 glioma cells in a Gβγ subunit and Ras dependent manner |
| PTK2B | Protein | ncbiprotein:NP_775266.1 | [Pubmed:10646507] have shown that stimulation of OPRK1 with U69,593 induces Tyr phosphorylation of PTK2B in C6 glioma cell line |
| FTH1 | Protein | ncbigene:2498 | [Pubmed: 19244528] have shown that Morphine and DAMGO stimulates OPRM1 and induces upregulation of FTH1 in rat cortical neurons and brain homogenates. |
| RGS4 | Protein | ncbigene:5999 | [Pubmed: 22056472] have shown that morphine stimulates MOR and induces upregulation of RGS4 in rat prefrontal cortex. |
| MCL1 | Protein | ncbiprotein:4170 | [Pubmed:22033345] have shown that methadone/Buprenorphine stimulates MOR and induces upregulation of MCL1 in rat oligodendrocytes. |
| RGS4 | Protein | ncbiprotein:NP_001095915.1 | [Pubmed:26119705] have shown that DAMGO stimulates MOR and induces the assciation of RGS4 and OPRM1 in rat brain membrane. |
| OPRM1 | Protein | ncbiprotein:NP_001138751.1 | [Pubmed:24113748] have shown that morphine stimulates MOR and induces association of FKBP1A to OPRM1 in HEK293 cells |
| GNAO1 | Protein | ncbiprotein:NP_620073.2 | [Pubmed:26119705] have shown that DAMGO stimulates MOR and induces the assciation of OPRM1 and GNAO1 in rat brain membrane. |
| OPRM1 | Protein | ncbiprotein:NP_001138751.1 | [Pubmed: 10334841] have shown that DAMGO stimulates OPRM1 and induces activation of OPRM1 in CHO-K1 cells |
| BCL2 | Protein | ncbiprotein:596 | [Pubmed: 15644942] have shown that endomorphins EM1 and EM2 stimulates MOR induces downregulation of BCL2 in HL60 cells |
| BAX | Protein | ncbiprotein:581 | [Pubmed: 15644942] have shown that endomorphins EM1 and EM2 stimulates MOR induces upregulation of BAX in HL60 cells |
| FAS | Protein | ncbiprotein:355 | [Pubmed: 15644942] have shown that endomorphins EM1 and EM2 stimulates MOR induces upregulation of FAS in HL60 cells |
| FASLG | Protein | ncbiprotein:356 | [Pubmed: 15644942] have shown that endomorphins EM1 and EM2 stimulates MOR induces upregulation of FASLG in HL60 cells |
| GRK2 | Protein | ncbiprotein:NP_001610.2 | [Pubmed: 12750434] have shown that DAMGO stimulates MOR and ORL1 receptor induces translocation of GRK2 from cytosol to plasma membrane in BE(2)-C cells |
| GRK3 | Protein | ncbiprotein:NP_005151.2 | [Pubmed: 12750434] have shown that DAMGO stimulates MOR and ORL1 receptor induces translocation of GRK3 from cytosol to plasma membrane in BE(2)-C cells |
| GATA4 | Protein | ncbigene:2626 | [Pubmed: 12623878] have shown that Dynorphin stimulatesKOR induces upregulation of GATA4 gene in a PKC dependent manner in nuclei isolated from undifferentiated ES cells |
| NKX2-5 | Protein | ncbiprotein:1482 | [Pubmed: 12623878] have shown that Dynorphin stimulates OPRM1 induces upregulation of NKX2-5 gene in a PKC dependent manner in nuclei isolated from undifferentiated ES cells |
| PDYN | Protein | ncbiprotein:5173 | [Pubmed: 12623878] have shown that Dynorphin stimulates KOR induces upregulation of PDYN gene in a PKC dependent manner in nuclei isolated from undifferentiated ES cells |
| ARRB2 | Protein | ncbiprotein:NP_001244257.1 | [Pubmed: 17565992] have shown that DPDPE stimulates association of OPRD1 with ARRB2 in HEK293 cells |
| ARRB1 | Protein | ncbiprotein:NP_004032.2 | [Pubmed: 17565992] have shown that DPDPE stimulates association of OPRD1 with ARRB1 in HEK293 cells. |
| CD14 | Protein | ncbiprotein:929 | [Pubmed: 17583593] have shown that morphine stimulates MOR induces downregulation of CD14 expression on the surface of human neutrophils |
| ADCY1 | Protein | ncbigene:107 | [Pubmed: 23682813] have shown that DAMGO treatment stimulates OPRM1 and induces upregulation of ADCY1 in mice striatum and prefrontal cortex |
| ADCY8 | Protein | ncbigene:114 | [Pubmed: 23682813] have shown that DAMGO treatment stimulates OPRM1 and induces upregulation of ADCY8 in mice striatum and prefrontal cortex |
| OPRM1 | Protein | ncbiprotein:NP_001138751.1 | [Pubmed: 26363797] have shown that DAMGO stimulates MOR and induces molecular association of OPRM1 and NISCH in CHO cells |
| NISCH | Protein | ncbiprotein:NP_009115.2 | [Pubmed: 26363797] have shown that DAMGO stimulates MOR and induces molecular association of OPRM1 and NISCH in CHO cells |
| SRC | Protein | ncbiprotein:NP_005408.1 | [Pubmed: 27634008] have shown that U50488 and Dynorphin stimulates OPRK1 and induces phosphorylation of SRC at Y416 in mouse primary hippocampal neurons |
| GRIN2B | Protein | ncbiprotein:NP_000825.2 | [Pubmed: 27634008] have shown that U50488 and Dynorphin stimulates KOR and induces phosphorylation of GRIN2B at Y1472 in mouse primary hippocampus |
| OPRK1 | Protein | ncbiprotein:NP_001305426.1 | [Pubmed:23775075] have shown that U-69,593 stimulates KOR and induces translocation of OPRK1 from plasma membrane to endosomein CHHO-KOR cells and mice striatal neurons.[Pubmed:23775075] have shown that U-69,593 stimulates KOR and induces molecular association of OPRK1 and ARRB2 in CHO-KOR cells and mice striatal neurons. |
| ARRB2 | Protein | ncbiprotein:NP_001244257.1 | [Pubmed:23775075] have shown that U-69,593 stimulates KOR and induces molecular association of OPRK1 and ARRB2 in CHO-KOR cells and mice striatal neurons. |
| MAPK1 | Protein | ncbiprotein:NP_002736.3 | [Pubmed:23775075] have shown that U-69,593 stimulates KOR and induces phosphorylation of MAPK1 in a G alpha-io dependent manner in CHO-KOR cells and mice striatal neurons.[Pubmed:25107591] have shown that SalA, U69,593 and U50,488 stimulates OPRK1 and induces phosphorylation of MAPK1 at Thr185/Tyr187 in EM4 cells.[Pubmed:26297384] have shown that U50,488 stimulates KOR and induces phosphorylation of MAPK1 at Thr185/Tyr187 in rat peripheral sensory neurons |
| MAPK3 | Protein | ncbiprotein:NP_002736.3 | [Pubmed:23775075] have shown that U-69,593 stimulates KOR and induces phosphorylation of MAPK3 in a G alpha-io dependent in CHO-KOR cells and mice striatal neurons.[Pubmed: 25107591] have shown that SalA, U69,593 and U50,488 stimulates OPRK1 and induces phosphorylation of MAPK3 at Thr202/Tyr204 in EM4 cells.[Pubmed:26297384] have shown that U50488 stimulates KOR and induces phosphorylation of MAPK3 at Thr202/Tyr204 in rat peripheral sensory neurons |
| ITGAM | Protein | ncbiprotein:3684 | [Pubmed:23844255] have shown that TAN-67 stimulates DOR and induces downregulation of ITGAM in rat cortex. |
| NCAM1 | Protein | ncbiprotein:4684 | [Pubmed:23906478] have shown that DSLET stimulates DOR and induces upregulation of NCAM1 in a STAT5B mediated manner in Neuro 2A cells. |
| SYP | Protein | ncbiprotein:6855 | [Pubmed:23906478] have shown that DSLET stimulates DOR and induces upregulation of SYP in a STAT5B mediated manner in Neuro 2A cells. |
| TUBB3 | Protein | ncbiprotein:10381 | [Pubmed:23906478] have shown that DSLET stimulates DOR and induces upregulation of NCAM1 in a STAT5B mediated manner in Neuro 2A cells. |
| OPRM1 | Protein | ncbiprotein:NP_001138751.1 | [Pubmed:23911290] have shown that morphine stimulates MOR and induces association of OPRM1 and TRPM8 in HEK293 cells. |
| TRPM8 | Protein | ncbiprotein:NP_076985.4 | [Pubmed:23911290] have shown that morphine stimulates MOR and induces association of OPRM1 and TRPM8 in HEK293 cells. |
| NTRK2 | Protein | ncbiprotein:4915 | [Pubmed:24055683] have shown that morphine stimulates MOR and induces downregulation of NTRK2 in rat dorsal raphe nucleus. |
| CRHR1 | Protein | ncbiprotein:1394 | [Pubmed:24055683] have shown that morphine stimulates MOR and induces downregulation of CRHR1 in rat dorsal raphe nucleus. |
| HTR1A | Protein | ncbiprotein:3350 | [Pubmed:24055683] have shown that morphine stimulates MOR and induces downregulation of HTR1A in rat dorsal raphe nucleus. |
| PRG4 | Protein | ncbiprotein:10216 | [Pubmed:28097228] have shown that dynorphinA/U-50,488H stimulates KOR and induces upregulation of PRG4 in a cAMP/PKA alpha/CREB dependent manner in human chondrocytes. |
| OPRM1 | Protein | ncbiprotein:NP_001138751.1 | [Pubmed:22375000] have shown that DAMGO stimulates OPRM1 and induces translocation of OPRM1 from plasma membrane to cytosol in human neuroblastoma SH-SY5Y cells.[Pubmed:31575621] have shown that DAMGO stimulates OPRM1 and induces phosphorylation of OPRM1 at Ser 363 in a G beta-gamma/PLC/PKC mediated manner in HEK293 cells |
| ARRB2 | Protein | ncbiprotein:NP_001244257.1 | [Pubmed:22375000] have hown that DAMGO stimulates MOR and induces translocation of ARRB2 from cytosol to plasma membrane in SH-SY5Y cells.[Pubmed: 22079772] have shown that co-administration of morphine and fentanyl stimulates OPRM1 and induces activation of ARRB2 in rat brain locus coeruleus and periaqueductal gray section |
| ARRB1 | Protein | ncbiprotein:NP_004032.2 | [Pubmed:22375000] have shown that DAMGO stimulates MOR and induces association of OPRM1 and ARRB1 in human neuroblastoma SH-SY5Y cells |
| OPRM1 | Protein | ncbiprotein:NP_001138751.1 | [Pubmed:22375000] have shown that DAMGO stimulates MOR and induces association of OPRM1 and ARRB1 in human neuroblastoma SH-SY5Y cells |
| MAPK14 | Protein | ncbiprotein:NP_001306.1 | Pubmed:25052197] have shown that UFP-512 stimulates DOR and induces phosphorylation of MAPK14 on Thr/Tyr at 180/182 in a MEK/ERK dependent manner in mouse astrocyte culture. |
| SLC1A3 | Protein | ncbiprotein:6507 | [Pubmed:25052197] have shown that UFP-512 stimulates DOR and induces upregulation of SLC1A3 protein in mouse astrocyte cultures |
| SLC1A2 | Protein | ncbiprotein:6506 | [Pubmed:25052197] have shown that UFP-512 stimulates DOR and induces upregulation of SLC1A2 protein in mouse astrocyte cultures |
| ECE2 | Protein | ncbiprotein:9718 | [Pubmed:24990314] have shown that DAMGO/dynorphin B stimulates MOR and induces upregulation of ECE2 in CHO cells. |
| OPRM1 | Protein | ncbiprotein:NP_001138751.1 | [Pubmed:24990314] have shown that DAMGO/fentanyl/dynorphin B stimulates MOR and induces translocation (recycling) of OPRM1 from endosome to plasma membrane in CHO and F11 cells.[Pubmed:31575621] have shown that DAMGO stimulates OPRM1 and induces translocation of OPRM1 from endosome to plasma membranel in HEK293 cells |
| KDR | Protein | ncbiprotein:3791 | [Pubmed:21460241] have shown that U-50,488H/TRK820 stimulates KOR and induces Gi/cAMP/PKA mediated downregulation of KDR in mouse endothelial cels. |
| NRP1 | Protein | ncbiprotein:8829 | [Pubmed:21460241] have shown that U-50,488H/TRK820 stimulates KOR and induces Gi/cAMP/PKA mediated downregulation of NRP1 in mouse endothelial cels. |
| AIF1 | Protein | ncbiprotein:199 | [Pubmed:19176808] have shown that morphine stimulates MOR and induces upregulation of AIF1 in rat microglia. |
| P2RX4 | Protein | ncbiprotein:5025 | [Pubmed:19176808] have shown that morphine stimulates MOR and induces upregulation of P2RX4 in rat microglia. |
| MAPK1 | Protein | ncbiprotein:NP_002736.3 | [Pubmed: 26763532] have shown that leucine-enkephalin stimulates DOR and induces phosphorylation of MAPK1 in HaCaT cells. |
| MAPK3 | Protein | ncbiprotein:NP_002736.3 | [Pubmed: 26763532] have shown that leucine-enkephalin stimulates DOR and induces phosphorylation of MAPK3 in HaCaT cells. |
| RPS6KA1 | Protein | ncbiprotein:NP_002944.2 | [Pubmed: 26763532] have shown that leucine-enkephalin stimulates DOR and induces phosphorylation of RPS6KA1 in HaCaT cells. |
| ELK1 | Protein | ncbiprotein:NP_001107595.1 | [Pubmed: 26763532] have shown that leucine-enkephalin stimulates DOR and induces phosphorylation of ELK1 in HaCaT cells. |
| MMP2 | Protein | ncbiprotein:4313 | [Pubmed:26763532] have shown that leucin enkephalin stimulates DOR and induces upregulation of MMP2 in HaCaT cells. |
| MMP9 | Protein | ncbiprotein:4318 | [Pubmed:26763532] have shown that leucin enkephalin stimulates DOR and induces upregulation of MMP9 in HaCaT cells. |
| OPRM1 | Protein | ncbiprotein:NP_001138751.1 | [Pubmed:20214800] have shown that morphine stimulates MOR and induces association of OPRM1 and WLS in HEK293 cells. |
| WLS | Protein | ncbiprotein:NP_001002292.3 | [Pubmed:20214800] have shown that morphine stimulates MOR and induces association of OPRM1 and WLS in HEK293 cells. |
| OPRL1 | Protein | ncbigene:4987 | [Pubmed:16311589] have shown that nociceptin stimulates ORL1 and induces translocation of OPRL1-CACNA1B complex from cell membrane to cytosol in CHO cells and rat DRG neurons. |
| E2F1 | Protein | ncbigene:1869 | [Pubmed:19765550] have shown that morphine stimulates MOR and induces upregulation of E2F1 in CEMx174 cells. |
| E2F1 | Protein | refseq:NP_005216.1 | [Pubmed:19765550] have shown that morphine stimulates MOR and induces association of E2F1 and YY1 in CEMx174 cells. |
| YY1 | Protein | ncbiprotein:NP_003394.1 | [Pubmed:19765550] have shown that morphine stimulates MOR and induces association of E2F1 and YY1 in CEMx174 cells. |
| E2F1 | Protein | refseq:NP_005216.1 | [Pubmed:19765550] have shown that morphine stimulates MOR and induces association of E2F1 and SP1 in CEMx174 cells. |
| SP1 | Protein | ncbiprotein:NP_612482.2 | [Pubmed:19765550] have shown that morphine stimulates MOR and induces association of E2F1 and SP1 in CEMx174 cells. |
| E2F1 | Protein | refseq:NP_005216.1 | [Pubmed:19765550] have shown that morphine stimulates MOR and induces the DNA binding of E2F1 to MOR promoter in CEMx174 cells. |
| RGS9 | Protein | refseq:NP_001075424.1 | [Pubmed:15632124] have shown that morphine stimulates MOR and induces phosphorylation of RGS9 at S475 in mouse PAG synaptosomes |
| GNAI2 | Protein | refseq:NP_002061.1 | [Pubmed:15632124] have shown that morphine stimulates MOR and induces association of RGS9 and GNAI2 in mouse PAG synaptosomes |
| GNAZ | Protein | refseq:NP_002064.1 | [Pubmed:15632124] have shown that morphine stimulates MOR and induces association of RGS9 and GNAZ in mouse PAG synaptosomes |
| YWHAQ | Protein | refseq:NP_006817.1 | [Pubmed:15632124] have shown that morphine stimulates MOR and induces association of RGS9 and YWHAQ in mouse PAG synaptosomes |
| SRC | Protein | ncbiprotein:NP_005408.1 | [Pubmed:24578342] have shown that DPDPE stimulates DOR and induces phosphorylation of SRC at Y416 in rabbit cultured smooth muscle cells |
| GNAI2 | Protein | ncbiprotein:NP_002061.1 | [Pubmed:24578342] have shown that DPDPE stimulates DOR and induces association of GNAI2 and RGS12 in a Gbeta/gamma-PI2K-cSRC mediated manner in rabbit cultured smooth muscle cells. |
| RGS12 | Protein | ncbiprotein:NP_937872.1 | [Pubmed:24578342] have shown that DPDPE stimulates DOR and induces association of GNAI2 and RGS12 in a Gbeta/gamma-PI2K-cSRC mediated manner in rabbit cultured smooth muscle cells. |
| GNAI2 | Protein | ncbigene:2771 | [Pubmed:15987828] have shown that DAMGO stimulates MOR and induces downregulation of GNAI2 in CHO cells. |
| NEU2 | Protein | ncbigene:4759 | [Pubmed:15987828] have shown that morphine stimulates MOR and induces downregulation of NEU2 in CHO cells. |
| GNA12 | Protein | ncbigene:2768 | [Pubmed:15987828] have shown that DAMGO stimulates MOR and induces upregulation of GNA12 in CHO cells. |
| RPLP2 | Protein | ncbigene:6181 | [Pubmed:15987828] have shown that morphine stimulates MOR and induces downregulation of RPLP2 in CHO cells. |
| JUP | Protein | ncbigene:3728 | [Pubmed:15987828] have shown that morphine stimulates MOR and induces up regulation of JUP in CHO cells. |
| PGM1 | Protein | ncbigene:5236 | [Pubmed:15987828] have shown that morphine stimulates MOR and induces up regulation of PGM1 in CHO cells. |
| UBQLN1 | Protein | ncbiprotein:29979 | [Pubmed:15987828] have shown that morphine stimulates MOR and induces up regulation of UBQLN1 in CHO cells. |
| TUBB | Protein | ncbigene:203068 | [Pubmed:15987828] have shown that morphine stimulates MOR and induces upregulation of TUBB in CHO cells. |
| HSPA8 | Protein | ncbigene:3312 | [Pubmed:15987828] have shown that morphine stimulates MOR and induces up regulation of HSPA8 in CHO cells. |
| ALDH9A1 | Protein | ncbigene:223 | [Pubmed:15987828] have shown that morphine stimulates MOR and induces up regulation of ALDH9A1 in CHO cells. |
| CAMK2A | Protein | ncbiprotein:NP_057065.2 | [Pubmed:16697745] have shown that DPDPE stimulates DOR and induces CAMK2A phosphorylation at Thr286 in rat BDL cholangiocytes |
| PCNA | Protein | ncbigene:511 | |
| PRKCA | Protein | ncbiprotein:NP_002728.1 | [Pubmed:16697745] have shown that DPDPE stimulates DOR and induces PRKCA phosphorylation at Ser 657 in rat BDL cholangiocytes |
| PCNA | Protein | ncbigene:511 | |
| ARC | Protein | ncbigene:23237 | [Pubmed:16211563] have shown that morphine stimulates MOR and induces upregulation of ARC in a PKC/MEK dependent manner in mouse striatum and Neuro2A cells. |
| GCK | Protein | ncbiprotein:2645 | [Pubmed:16140165] have shown that tramadol stimulates OPRM1 and induces upregulation of GCK in rat cortex and hypothalamus. |
| IRS2 | Protein | ncbiprotein:8660 | [Pubmed:16140165] have shown that tramadol stimulates OPRM1 and induces upregulation of IRS2 in rat primary neuronal cells. |
| NEUROD1 | Protein | ncbiprotein:4790 | [Pubmed:20554861] have shown that fentanyl stimulates MOR and induces upregulation of NEUROD1 in rat hippocampal neurons. |
| ADM | Protein | ncbiprotein:133 | [Pubmed:20844145] have shown that morphine stimulates MOR and induces upregulation of ADM in a PKC mediated manner in rat DRG neurons. |
| CALCA | Protein | ncbiprotein:796 | [Pubmed:20844145] have shown that morphine stimulates MOR and induces upregulation of CALCA in a PKC mediated manner in rat DRG neurons. |
| GJA1 | Protein | ncbiprotein:2697 | [Pubmed:23011166] have shown that U50,488H stimulates KOR and induces upregulation of GJA1 mRNA in rat ventricles. |
| GFAP | Protein | ncbiprotein:2670 | [Pubmed: 25806604] have shown that morphine stimulates MOR and induces the upregulation of GFAP in mouse spinal cord. |
| ARR3 | Protein | ncbiprotein:NP_004303.2 | [Pubmed:22553358] have shown that morphine stimulates MOR and induces OPRM1 and ARR3 association in HEK293 cells |
| OPRM1 | Protein | ncbiprotein:NP_001138751.1 | [Pubmed:22553358] have shown that morphine stimulates MOR and induces OPRM1 and ARR3 association in HEK293 cells |
| PIK3R1 | Protein | ncbiprotein:5295 | [Pubmed: 18588537] have shown that chronic morphine treatment stimulates MOR and induces upregulation of PIK3R1 in mouse central extended amygdala |
| GNAI3 | Protein | ncbiprotein:NP_006487.1 | [Pubmed:24976397] have shown that DAMGO, deltorphinII and DPDPE stimulates MOR, MOR-DOR heteromer and DOR respectively and induces activation of GNAI3 in rat striatum and hippocampi |
| SLC6A4 | Protein | ncbiprotein:NP_001036.1 | [Pubmed:25107591] have shown that SalA stimulates KOR and induces activation of SLC6A4 in EM4 cells |
| MAPK8 | Protein | ncbiprotein:NP_001265476.1 | [Pubmed:31347026] have shown that morphine stimulates MOR and induces phosphorylation of MAPK8 at Tyr 185 in mouse spinal cord. |
| NOTCH1 | Protein | ncbiprotein:4851 | [Pubmed:31347026] have shown that morphine stimulates MOR and induces upregulation of NOTCH1 in mouse spinal cord |
| PRKCE | Protein | ncbigene:5581 | [Pubmed:31347026] have shown that morphine stimulates MOR and induces upregulation of PRKCE in mouse spinal cord. |
| PRKCG | Protein | ncbigene:5582 | [Pubmed:31347026] have shown that morphine stimulates MOR and induces upregulation of PRKCG in mouse spinal cord. |
| HDAC1 | Protein | ncbigene:3065 | [Pubmed:31347026] have shown that morphine stimulates MOR and induces downregulation of HDAC1 in mouse spinal cord. |
| DNMT3A | Protein | ncbigene:1788 | [Pubmed:31347026] have shown that morphine stimulates MOR and induces upregulation of DNMT3A in mouse spinal cord. |
| OPRM1 | Protein | ncbiprotein:NP_001138751.1 | [Pubmed:31347026] have shown that morphine stimulates MOR and induces molecular association of OPRM1 and HDAC1 in mouse spinal cord. |
| PRKCE | Protein | ncbiprotein:NP_005391.1 | [Pubmed:31347026] have shown that morphine stimulates MOR and induces phosphorylation of PRKCE at Ser 729 in mouse spinal cord. |
| PRKCG | Protein | ncbiprotein:NP_001303258.1 | [Pubmed:31347026] have shown that morphine stimulates MOR and induces phosphorylation of PRKCG at Thr 512 in mouse spinal cord. |
| HMOX1 | Protein | ncbigene:3162 | [Pubmed:30595095] have shown that dynorphin A stimulates KOR and induces upregulation of HMOX1 in rat hippocampal neurons. |
| MAP1LC3B | Protein | ncbigene:81631 | [Pubmed:32955950] have shown that BW373U86 stimulates DOR and induces upregulation of MAP1LC3B in hypoxic rat cardiomyocytes. |
| SQSTM1 | Protein | ncbigene:8878 | [Pubmed:32955950] have shown that BW373U86 stimulates DOR and induces downregulation of SQSTM1 in hypoxic rat cardiomyocytes. |
| MAPK14 | Protein | ncbiprotein:NP_001306.1 | [Pubmed:10501195] have shown that DPDPE or N/OFQ stimulate DOR and ORL1 respectively and induce phosphorylation of MAPK14 at Thr 180 /Tyr 182 in a PKA dependent manner in NG108-15 cells. |
| ATF2 | Protein | ncbiprotein:NP_001871.2 | [Pubmed:10501195] have shown that DPDPE and N/OFQ stimulate DOR and ORL1 respectively and induce phosphorylation of ATF2 downstream of MAPK14 in NG108-15 cells. |
| MBP | Protein | ncbigene:4155 | [Pubmed:10501195] have shown that DPDPE and N/OFQ stimulate DOR and ORL1 respectively and induce upregulation of MBP downstream of MAPK14 in NG108-15 cells. |
| HDAC1 | Protein | ncbigene:3065 | [Pubmed:31347026] have shown that morphine stimulates MOR and induces molecular association of OPRM1 and HDAC1 in mouse spinal cord. |
| MAPK1 | Protein | ncbiprotein:NP_002736.3 | [Pubmed:10501195] have shown that DPDPE and N/OFQ stimulate DOR and ORL1 respectively and induce phosphorylation of MAPK1 at Thr185 and Tyr187 in a PKC dependent manner in NG108-15 cells. |
| MAPK3 | Protein | ncbiprotein:NP_002736.3 | [Pubmed:10501195] have shown that DPDPE and N/OFQ stimulate DOR and ORL1 respectively and induce phosphorylation of MAPK3 at Thr202 and Tyr204 in a PKC dependent manner in NG108-15 cells |
| OPRM1 | Protein | ncbiprotein:NP_001138751.1 | [Pubmed:24061856] have shown that morphine stimulates MOR and induces phosphorylation of OPRM1 at Tyr336 in HEK293 cells. |
| BDNF | Protein | ncbiprotein:627 | [Pubmed:24055683] have shown that morphine stimulates MOR and induces downregulation of BDNF in rat dorsal raphe nucleus. |
References
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- ADP-ribosylation factor 6 regulates mu-opioid receptor trafficking and signaling via activation of phospholipase D2. Rankovic M, Jacob L, Rankovic V, Brandenburg LO, Schröder H, Höllt V, et al. Cell Signal. 2009 Dec;21(12):1784–93. PubMed Europe PMC Scholia
- PI3Kγ integrates cAMP and Akt signalling of the μ-opioid receptor. Madishetti S, Schneble N, König C, Hirsch E, Schulz S, Müller JP, et al. Br J Pharmacol. 2014 Jul;171(13):3328–37. PubMed Europe PMC Scholia