Aerobic glycolysis - augmented (WP4628)
Homo sapiens
Glycolysis converts glucose, C6H12O6, into pyruvate, CH3COCOO- and H+. The free energy released in this process is used to form the ATP and NADH. This pathway shows changed glycolytic fluxes during the Warburg effect. It is an extended version of the glycolysis pathway (WP534), and describes content in the computer model of the corresponding supplement, and the article of Shestov et al., 2014. Passive transport of oxygen and lactic acid into the cell is depicted using dashed arrows, which may differ from the original computer model. Referred article: Shestov et al., 2014
Authors
Kelly Janssen , Egon Willighagen , Alex Pico , Denise Slenter , Lauren J. Dupuis , Eric Weitz , Finterly Hu , Kristina Hanspers , and Aishwarya IyerActivity
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Organisms
Homo sapiensCommunities
ONTOXAnnotations
Pathway Ontology
gluconeogenesis pathway glycolysis/gluconeogenesis pathway cancer pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| O2 | Metabolite | chebi:26689 | |
| ATP | Metabolite | chebi:15422 | |
| AMP | Metabolite | chebi:16027 | |
| H | Metabolite | chebi:49637 | |
| _2PG | Metabolite | hmdb:HMDB0000362 | |
| BPG | Metabolite | hmdb:HMDB0001270 | |
| PYR | Metabolite | hmdb:HMDB0000243 | |
| GAP | Metabolite | hmdb:HMDB0001112 | |
| G6P | Metabolite | chebi:75052 | Glucose-6-Phosphate (2-) |
| LAC | Metabolite | hmdb:HMDB0000190 | |
| PEP | Metabolite | hmdb:HMDB0000263 | |
| _3PG | Metabolite | hmdb:HMDB0000807 | |
| GLU | Metabolite | hmdb:HMDB0000122 | |
| F6P | Metabolite | chebi:61527 | |
| DHAP | Metabolite | hmdb:HMDB0001473 | |
| GLUe | Metabolite | hmdb:HMDB0000122 | |
| ADP | Metabolite | chebi:16761 | |
| FBP | Metabolite | hmdb:HMDB0001058 | |
| NAD | Metabolite | chebi:15846 | |
| P | Metabolite | chebi:28659 | |
| NADH | Metabolite | chebi:16908 | |
| LACe | Metabolite | hmdb:HMDB0000190 | |
| F26BP | Metabolite | hmdb:HMDB0001047 | |
| CR | Metabolite | hmdb:HMDB0000064 | |
| PCR | Metabolite | hmdb:HMDB0001511 | |
| SER | Metabolite | hmdb:HMDB0000187 | |
| GLY | Metabolite | hmdb:HMDB0000187 | |
| H2O | Metabolite | chebi:26689 | |
| O2e | Metabolite | chebi:26689 | |
| HK | GeneProduct | ncbigene:3098 | |
| GLUT | GeneProduct | ncbigene:6513 | |
| PGK | GeneProduct | ncbigene:5230 | |
| ENO | GeneProduct | ncbigene:2023 | |
| GPI | GeneProduct | ncbigene:2821 | glucose-6-phosphate isomerase |
| LDH | GeneProduct | ncbigene:3939 | |
| G6PDH | GeneProduct | hgnc:4057 | |
| PK | GeneProduct | ncbigene:5315 | |
| ALD | GeneProduct | ncbigene:226 | |
| PFK | GeneProduct | ncbigene:5213 | |
| GAPDH | GeneProduct | ensembl:ENSG00000111640 | |
| PGM | GeneProduct | ncbigene:5224 | |
| TPI | GeneProduct | ncbigene:7167 | |
| AK | GeneProduct | eccode:2.7.4.3 | |
| CK | GeneProduct | eccode:2.7.3.2 | |
| GHMT | GeneProduct | eccode:2.1.2.1 | |
| GPT | GeneProduct | ncbigene:2875 |
References
- Biochemistry, Fifth Edition [Internet]. Berg JM, Tymoczko JL, Stryer L. 2002. 1096 p. Available from: https://books.google.com/books/about/Biochemistry_Fifth_Edition.html?hl=&id=pMxpAAAAMAAJ OpenLibrary Worldcat
- Pyruvate kinase. Classes of regulatory isoenzymes in mammalian tissues. Carbonell J, Felíu JE, Marco R, Sols A. Eur J Biochem. 1973 Aug 1;37(1):148–56. PubMed Europe PMC Scholia
- Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step. Shestov AA, Liu X, Ser Z, Cluntun AA, Hung YP, Huang L, et al. Elife. 2014 Jul 9;3:e03342. PubMed Europe PMC Scholia