Aerobic glycolysis - augmented (WP4628)

Homo sapiens

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Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO- and H+. The free energy released in this process is used to form the ATP and NADH. This pathway was made during a research project at the UMCG, concerning changed glycolytic fluxes during the Warburg effect. It is an extended version of the glycolysis pathway (WP534), and is descriptive of the content that is provided in the computer model of the corresponding supplement, and the article of [https://www.ncbi.nlm.nih.gov/pubmed/25009227 Shestov et al., 2014]. For the purposes of this WikiPathways model, the passive transport of oxygen and lactic acid into the cell is depicted using dashed arrows, which may differ from the original computer model. This pathway was uploaded to provide a high resolution version to readers of the thesis. Description and pathway adapted from [https://www.wikipathways.org/index.php/Pathway:WP534] Referred article: [https://www.ncbi.nlm.nih.gov/pubmed/25009227 Shestov et al., 2014]

Authors

Kelly Janssen , Egon Willighagen , Alex Pico , Denise Slenter , Lauren J. Dupuis , Eric Weitz , Finterly Hu , Kristina Hanspers , and Aishwarya Iyer

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

glycolysis/gluconeogenesis pathway gluconeogenesis pathway cancer pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
O2 Metabolite chebi:26689
ATP Metabolite chebi:15422
AMP Metabolite chebi:16027
H Metabolite chebi:49637
_2PG Metabolite hmdb:HMDB0000362
BPG Metabolite hmdb:HMDB0001270
PYR Metabolite hmdb:HMDB0000243
GAP Metabolite hmdb:HMDB0001112
G6P Metabolite chebi:75052 Glucose-6-Phosphate (2-)
LAC Metabolite hmdb:HMDB0000190
PEP Metabolite hmdb:HMDB0000263
_3PG Metabolite hmdb:HMDB0000807
GLU Metabolite hmdb:HMDB0000122
F6P Metabolite chebi:61527
DHAP Metabolite hmdb:HMDB0001473
GLUe Metabolite hmdb:HMDB0000122
ADP Metabolite chebi:16761
FBP Metabolite hmdb:HMDB0001058
NAD Metabolite chebi:15846
P Metabolite chebi:28659
NADH Metabolite chebi:16908
LACe Metabolite hmdb:HMDB0000190
F26BP Metabolite hmdb:HMDB0001047
CR Metabolite hmdb:HMDB0000064
PCR Metabolite hmdb:HMDB0001511
SER Metabolite hmdb:HMDB0000187
GLY Metabolite hmdb:HMDB0000187
H2O Metabolite chebi:26689
O2e Metabolite chebi:26689
HK GeneProduct ncbigene:3098
GLUT GeneProduct ncbigene:6513
PGK GeneProduct ncbigene:5230
ENO GeneProduct ncbigene:2023
GPI GeneProduct ncbigene:2821 glucose-6-phosphate isomerase
LDH GeneProduct ncbigene:3939
G6PDH GeneProduct hgnc:4057
PK GeneProduct ncbigene:5315
ALD GeneProduct ncbigene:226
PFK GeneProduct ncbigene:5213
GAPDH GeneProduct ensembl:ENSG00000111640
PGM GeneProduct ncbigene:5224
TPI GeneProduct ncbigene:7167
AK GeneProduct eccode:2.7.4.3
CK GeneProduct eccode:2.7.3.2
GHMT GeneProduct eccode:2.1.2.1
GPT GeneProduct ncbigene:2875

References

  1. Biochemistry, Fifth Edition [Internet]. Berg JM, Tymoczko JL, Stryer L. 2002. 1096 p. Available from: https://books.google.com/books/about/Biochemistry_Fifth_Edition.html?hl=&id=pMxpAAAAMAAJ OpenLibrary Worldcat
  2. Pyruvate kinase. Classes of regulatory isoenzymes in mammalian tissues. Carbonell J, Felíu JE, Marco R, Sols A. Eur J Biochem. 1973 Aug 1;37(1):148–56. PubMed Europe PMC Scholia
  3. Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step. Shestov AA, Liu X, Ser Z, Cluntun AA, Hung YP, Huang L, et al. Elife. 2014 Jul 9;3:e03342. PubMed Europe PMC Scholia