Growth factors and hormones in beta cell proliferation (WP5385)

Homo sapiens

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Growh factors and hormones in Beta-cell proliferation

Authors

Leyla Önder , Cereno98 , Petra Tesic , Egon Willighagen , Kristina Hanspers , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

Ras family mediated signaling pathway phosphatidylinositol 3-kinase-Akt signaling pathway calcium/calcium-mediated signaling pathway insulin signaling pathway transforming growth factor-beta superfamily mediated signaling pathway

Cell Type Ontology

type B pancreatic cell

Participants
Query Drugst.One

Label Type Compact URI Comment
T3 Metabolite chebi:18258
T4 Metabolite chebi:18332
Ca2+ Metabolite chebi:29108
Pdx1 GeneProduct uniprot:P52945
PI3K GeneProduct interpro:IPR000403 The InterPro indentifier for the family was selected, as no specifc protein of the family was stated in the publication.
ERK 1 GeneProduct uniprot:P27361
PDGFR-a GeneProduct uniprot:A0A387LBM6 In contrast to the pathway figure, the specific receptor was included as DataNode.
TGFB1 GeneProduct uniprot:P01137
AKT1 GeneProduct uniprot:P31749
TGFB1R GeneProduct uniprot:P36897
TRs GeneProduct interpro:IPR001728
K-Ras GeneProduct uniprot:P01116
P16ink4a GeneProduct uniprot:R9S252
NFAT GeneProduct interpro:IPR008366 The InterPro indentifier for the family was selected, as no specifc protein of the family was stated in the publication.
Insulin GeneProduct uniprot:P01308
PDGFa GeneProduct uniprot:P04085
EZH2 GeneProduct uniprot:Q75MQ0
B-Raf GeneProduct uniprot:P15056
IGF-1R GeneProduct uniprot:P08069 In contrast to the pathway figure, the specific receptor was included as DataNode.
Smad7 GeneProduct uniprot:O15105
PLGF GeneProduct uniprot:P49763
Rab43 GeneProduct uniprot:Q86YS6
CRTC2 GeneProduct uniprot:Q53ET0
VEGFR-1 GeneProduct uniprot:P17948 The pathway figure namesthe receptor for PLGF as PLGF. The UniProt websites states that the receptor for PLGF is VEGFR-1. But the original publication (PMID: 25924650) states VEGFR-1 as receptor.
FOXO1 GeneProduct uniprot:Q12778
IR GeneProduct uniprot:P06213 In contrast to the pathway figure, the specific receptor was included as DataNode.
IGF-1 GeneProduct uniprot:P05019
Pref-1 GeneProduct uniprot:P80370 Synonyms: Dlk-1
Rasf1a GeneProduct uniprot:Q9NS23
cMyc GeneProduct uniprot:P01106
CDK2 GeneProduct uniprot:P24941
CDK4 GeneProduct uniprot:P11802
FOXM1 GeneProduct uniprot:Q08050
ERK 2 GeneProduct uniprot:P28482
AKT2 GeneProduct uniprot:P31751
AKT3 GeneProduct uniprot:Q9Y243

References

  1. Compromised beta-cell development and beta-cell dysfunction in weanling offspring from dams maintained on a high-fat diet during gestation. Cerf ME, Williams K, Chapman CS, Louw J. Pancreas. 2007 Apr;34(3):347–53. PubMed Europe PMC Scholia
  2. EGF regulates survivin stability through the Raf-1/ERK pathway in insulin-secreting pancreatic β-cells. Wang H, Gambosova K, Cooper ZA, Holloway MP, Kassai A, Izquierdo D, et al. BMC Mol Biol. 2010 Aug 31;11:66. PubMed Europe PMC Scholia
  3. Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms. Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, et al. Cell Metab. 2010 Dec 1;12(6):619–32. PubMed Europe PMC Scholia
  4. Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet β-cells. Demozay D, Tsunekawa S, Briaud I, Shah R, Rhodes CJ. Diabetes. 2011 Nov;60(11):2892–902. PubMed Europe PMC Scholia
  5. PDGF signalling controls age-dependent proliferation in pancreatic β-cells. Chen H, Gu X, Liu Y, Wang J, Wirt SE, Bottino R, et al. Nature. 2011 Oct 12;478(7369):349–55. PubMed Europe PMC Scholia
  6. Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT. Goodyer WR, Gu X, Liu Y, Bottino R, Crabtree GR, Kim SK. Dev Cell. 2012 Jul 17;23(1):21–34. PubMed Europe PMC Scholia
  7. Triiodothyronine induces proliferation of pancreatic β-cells through the MAPK/ERK pathway. Kim TK, Lee JS, Jung HS, Ha TK, Kim SM, Han N, et al. Exp Clin Endocrinol Diabetes. 2014 Apr;122(4):240–5. PubMed Europe PMC Scholia
  8. M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7. Xiao X, Gaffar I, Guo P, Wiersch J, Fischbach S, Peirish L, et al. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):E1211-20. PubMed Europe PMC Scholia
  9. Menin determines K-RAS proliferative outputs in endocrine cells. Chamberlain CE, Scheel DW, McGlynn K, Kim H, Miyatsuka T, Wang J, et al. J Clin Invest. 2014 Sep;124(9):4093–101. PubMed Europe PMC Scholia
  10. Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway. Blum B, Roose AN, Barrandon O, Maehr R, Arvanites AC, Davidow LS, et al. Elife. 2014 Sep 16;3:e02809. PubMed Europe PMC Scholia
  11. Exendin-4 Promotes Beta Cell Proliferation via PI3k/Akt Signalling Pathway. Wang C, Chen X, Ding X, He Y, Gu C, Zhou L. Cell Physiol Biochem. 2015;35(6):2223–32. PubMed Europe PMC Scholia
  12. Pre-Eclampsia-Associated Reduction in Placental Growth Factor Impaired Beta Cell Proliferation Through PI3k Signalling. Li J, Ying H, Cai G, Guo Q, Chen L. Cell Physiol Biochem. 2015;36(1):34–43. PubMed Europe PMC Scholia
  13. Effects of phycocyanin on INS-1 pancreatic β-cell mediated by PI3K/Akt/FoxO1 signaling pathway. Gao Y, Liao G, Xiang C, Yang X, Cheng X, Ou Y. Int J Biol Macromol. 2016 Feb;83:185–94. PubMed Europe PMC Scholia
  14. Preadipocyte factor 1 induces pancreatic ductal cell differentiation into insulin-producing cells. Rhee M, Lee SH, Kim JW, Ham DS, Park HS, Yang HK, et al. Sci Rep. 2016 Apr 5;6:23960. PubMed Europe PMC Scholia
  15. Cellular signaling pathways regulating β-cell proliferation as a promising therapeutic target in the treatment of diabetes. Jiang WJ, Peng YC, Yang KM. Exp Ther Med. 2018 Oct;16(4):3275–85. PubMed Europe PMC Scholia
  16. The Role of Calcium-Calcineurin-NFAT Signaling Pathway in Health and Autoimmune Diseases. Park YJ, Yoo SA, Kim M, Kim WU. Front Immunol. 2020 Mar 10;11:195. PubMed Europe PMC Scholia