Apoptosis modulation by HSP70 (WP1082)

Bos taurus

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This pathway summarizes the various ways by which HSP70 proteins can inhibit apoptosis.

Authors

Andra Waagmeester , Christine Chichester , Martina Summer-Kutmon , Kristina Hanspers , Eric Weitz , and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

apoptotic cell death pathway

Participants

Label Type Compact URI Comment
MAP3K1 GeneProduct ensembl:ENSBTAG00000013790 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4214
CASP8 GeneProduct ensembl:ENSBTAG00000015718 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:841
CASP3 GeneProduct ensembl:ENSBTAG00000015874 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:836
FADD GeneProduct ensembl:ENSBTAG00000018274 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8772
BID2 GeneProduct ensembl:ENSBTAG00000013988 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:637
CASP2 GeneProduct ensembl:ENSBTAG00000018159 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:835
CASP6 GeneProduct ensembl:ENSBTAG00000012537 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:839
CASP7 GeneProduct ensembl:ENSBTAG00000006615 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:840
FAS GeneProduct ensembl:ENSBTAG00000010785 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:355
AIFM1 GeneProduct ensembl:ENSBTAG00000006838 Apoptosis Inducing Factor
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9131
CYCS GeneProduct ensembl:ENSBTAG00000022613 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54205
APAF1 GeneProduct ensembl:ENSBTAG00000021661 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:317
CASP9 GeneProduct ensembl:ENSBTAG00000002472 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:842
NFKB1 GeneProduct ensembl:ENSBTAG00000020270 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
TNFRSF1A GeneProduct ensembl:ENSBTAG00000004211 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7132
RIPK1 GeneProduct ensembl:ENSBTAG00000006378 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8737
MAPK10 GeneProduct ensembl:ENSBTAG00000020048 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5602
FASLG GeneProduct ensembl:ENSBTAG00000032808 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117560

References

  1. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. Jäättelä M, Wissing D, Kokholm K, Kallunki T, Egeblad M. EMBO J. 1998 Nov 2;17(21):6124–34. PubMed Europe PMC Scholia
  2. Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging. Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY. FEBS Lett. 1998 Oct 30;438(1–2):1–4. PubMed Europe PMC Scholia
  3. Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70. Schett G, Steiner CW, Gröger M, Winkler S, Graninger W, Smolen J, et al. FASEB J. 1999 May;13(8):833–42. PubMed Europe PMC Scholia
  4. Negative regulation of the Apaf-1 apoptosome by Hsp70. Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES. Nat Cell Biol. 2000 Aug;2(8):476–83. PubMed Europe PMC Scholia
  5. The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, et al. Mol Cell Biol. 2000 Oct;20(19):7146–59. PubMed Europe PMC Scholia
  6. HSP27 and HSP70: potentially oncogenic apoptosis inhibitors. Garrido C, Schmitt E, Candé C, Vahsen N, Parcellier A, Kroemer G. Cell Cycle. 2003;2(6):579–84. PubMed Europe PMC Scholia
  7. Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor. Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, et al. Oncogene. 2003 Oct 2;22(43):6669–78. PubMed Europe PMC Scholia
  8. The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential. Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, et al. J Biol Chem. 2004 Jun 11;279(24):25689–95. PubMed Europe PMC Scholia