Human pathways

10q11.21q11.23 copy number variation syndrome

10q22q23 copy number variation

11p11.2 copy number variation syndrome

13q12 or CRYL1 copy number variation

13q12.12 copy number variation

15q11.2 copy number variation syndrome

15q11q13 copy number variation

15q13.3 copy number variation syndrome

15q25 copy number variation

16p11.2 distal deletion syndrome

16p11.2 proximal deletion syndrome

16p13.11 copy number variation syndrome

17p13.3 (YWHAE) copy number variation

17q12 copy number variation syndrome

1p36 copy number variation syndrome

1q21.1 copy number variation syndrome

22q11.2 copy number variation syndrome

2q11.2 copy number variation syndrome

2q13 copy number variation syndrome

2q21.1 copy number variation syndrome

2q37 copy number variation syndrome

3q29 copy number variation syndrome

4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression

4p16.3 copy number variation

5q35 copy number variation

6q16 copy number variation

7-oxo-C and 7-beta-HC pathways

7q11.23 copy number variation syndrome

7q11.23 distal copy number variation

8p23.1 copy number variation syndrome

8q11.23 (RB1CC1) copy number variation

ACE inhibitor pathway

ACE2 inhibition leads to pulmonary fibrosis

ADHD and autism (ASD) pathways

AGE/RAGE pathway

ALA oxylipin metabolism

AMP-activated protein kinase signaling

AMPK regulation of mammary milk protein synthesis

ATM signaling

ATM signaling in development and disease

ATR signaling

Abnormal calcium handling and its effects on muscle contraction in DMD

Acetaminophen in analgesia and antipyresis

Acetylcholine synthesis

Acquired partial lipodystrophy / Barraquer-Simons syndrome

Acrylamide biotransformation and exposure biomarkers

Activation of NLRP3 inflammasome by SARS-CoV-2

Acute myeloid leukemia

Acute viral myocarditis

Adipogenesis

Adverse outcome pathway for mitochondrial complex 1 (C1) inhibition

Aerobic glycolysis

Aerobic glycolysis - augmented

Affected pathways in Duchenne muscular dystrophy

Aflatoxin B1 metabolism

Airway smooth muscle cell contraction

Alanine and aspartate metabolism

Albuterol and budesonide therapy for asthma

Allograft rejection

Alpha 6 beta 4 signaling

Alstrom syndrome

Altered glycosylation of MUC1 in tumor microenvironment

Alternative pathway of fetal androgen synthesis

Alzheimer's disease

Alzheimer's disease and miRNA effects

Amino acid conjugation

Amino acid conjugation of benzoic acid

Amino acid metabolism

Amino acid metabolism in triple-negative breast cancer cells

Amino acid metabolism pathway excerpt: histidine catabolism extension

Amino acid transport defects (IEMs)

Amplification and expansion of oncogenic pathways as metastatic traits

Amyotrophic lateral sclerosis (ALS)

Androgen receptor network in prostate cancer

Androgen receptor signaling

Angiogenesis

Angiopoietin-like protein 8 regulatory pathway

Angiotensin II receptor type 1 pathway

Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway

ApoE and miR-146 in inflammation and atherosclerosis

Apoptosis

Apoptosis modulation and signaling

Apoptosis modulation by HSP70

Apoptosis-related network due to altered Notch3 in ovarian cancer

Arachidonate epoxygenase / epoxide hydrolase

Arachidonic acid (AA, ARA) oxylipin metabolism

Aripiprazole metabolic pathway

Arrhythmogenic right ventricular cardiomyopathy

Arsenic liver toxicity pathway

Arsenic metabolism and reactive oxygen species generation

Artemisinin inhibition of uveal melanoma

Aryl hydrocarbon receptor pathway

Aryl hydrocarbon receptor pathway

Arylamine metabolism

Aspirin and miRNAs

Autophagy

Autophagy in pancreatic ductal adenocarcinoma

Autosomal recessive osteopetrosis pathways

Axon guidance

B cell receptor signaling

BDNF-TrkB signaling

BMP signaling in eyelid development

BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation

Bardet-Biedl syndrome

Base excision repair

Bempedoic acid therapy in atherosclerosis and metabolic syndrome

Benzene metabolism

Benzo(a)pyrene metabolism

Bile acid synthesis and enterohepatic circulation

Biochemical pathways: part I

Biogenic amine synthesis

Biomarkers for pyrimidine metabolism disorders

Biomarkers for urea cycle disorders

Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine

Biosynthesis and turnover of 1-deoxy-sphingoid bases

Biotin metabolism, including IMDs

Bladder cancer

Blood clotting and drug effects

Blood clotting cascade

Bone morphogenic protein signaling and regulation

Brain-derived neurotrophic factor (BDNF) signaling

Breast cancer pathway

Burn wound healing

Butyrate-induced histone acetylation

CAMKK2 pathway

CCL18 signaling

COVID-19 adverse outcome pathway

COVID-19 and endothelial cell senescence

COVID-19 structural coverage map

COVID-19, thrombosis and anticoagulation

Caffeine and theobromine metabolism

Calcium mediated T-cell apoptosis involved in inclusion body myositis

Calcium regulation in cardiac cells

Caloric restriction and aging

Cancer immunotherapy by CTLA4 blockade

Cancer immunotherapy by PD-1 blockade

Cancer pathways

Cannabinoid receptor signaling

Canonical NF-kB pathway

Canonical and non-canonical Notch signaling

Canonical and non-canonical TGF-B signaling

Cardiac hypertrophic response

Cardiac progenitor differentiation

Cardiomyocyte signaling converging on titin

Carnosine metabolism of glial cells

Catabolism of skeletal muscle in cachexia

Catalytic cycle of mammalian flavin-containing monooxygenases (FMOs)

Cell cycle

Cell differentiation - expanded index

Cell differentiation - index

Cell interactions of the pancreatic cancer microenvironment

Cell lineage map for neuronal differentiation

Cell-type dependent selectivity of CCK2R signaling

Cells and molecules involved in local acute inflammatory response

Cellular proteostasis

Cerebral organic acidurias, including diseases

Chemokine signaling

Cholestasis

Cholesterol biosynthesis pathway

Cholesterol biosynthesis pathway in hepatocytes

Cholesterol biosynthesis with skeletal dysplasias

Cholesterol metabolism

Cholesterol metabolism with Bloch and Kandutsch-Russell pathways

Cholesterol synthesis disorders

Chromosomal and microsatellite instability in colorectal cancer

Chronic hyperglycemia impairment of neuron function

Ciliary landscape

Ciliopathies

Circadian rhythm genes

Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism

Clear cell renal cell carcinoma pathways

Clock-controlled autophagy in bone metabolism

Cocaine metabolism

Codeine and morphine metabolism

Cohesin complex - Cornelia de Lange syndrome

Colchicine metabolic pathway

Common pathways underlying drug addiction

Complement activation

Complement and coagulation cascades

Complement system

Complement system in neuronal development and plasticity

Complement-mediated inflammation of pulmonary alveolus in COVID-19 (hypothetical pathway)

Congenital generalized lipodystrophy

Constitutive androstane receptor pathway

Control of immune tolerance by vasoactive intestinal peptide

Conversion of angiotensinogen to angiotensin II

Copper homeostasis

Copper metabolism

Cori cycle

Corticotropin-releasing hormone signaling

Creatine pathway

Cyclin-dependent kinase 4/6 inhibitors in breast cancer

Cysteine and methionine catabolism

Cytokine-cytokine receptor interaction

Cytokines and inflammatory response

Cytoplasmic ribosomal proteins

Cytosine methylation

Cytosolic DNA-sensing pathway

DDX1 as a regulatory component of the Drosha microprocessor

DNA IR-damage and cellular response via ATR

DNA IR-double strand breaks and cellular response via ATM

DNA adduct formation leading to kidney failure

DNA damage response

DNA damage response (only ATM dependent)

DNA mismatch repair

DNA repair pathways, full network

DNA replication

DYRK1A involvement regarding cell proliferation in brain development

Degradation pathway of sphingolipids, including diseases

Dengue-2 interactions with complement and coagulation cascades

Deregulation of Rab and Rab effector genes in bladder cancer

Development and heterogeneity of the ILC family

Development of pulmonary dendritic cells and macrophage subsets

Development of ureteric derived collecting system

Diclofenac metabolic pathway

Diet-dependent trimethylamine/trimethylamine N-oxide metabolism

Differentiation of white and brown adipocyte

Direct reversal repair

Disorders in ketolysis

Disorders in ketone body synthesis

Disorders of Mitochondrial Homeostatis, Dynamics, Protein Import, and Quality Control

Disorders of NAD metabolism

Disorders of bile acid synthesis and biliary transport

Disorders of folate metabolism and transport

Disorders of fructose metabolism

Disorders of galactose metabolism

Disruption of postsynaptic signaling by CNV

Docosahexaenoic acid oxylipin metabolism

Dopamine metabolism

Dopaminergic neurogenesis

Downregulation of ACE2 by SARS-CoV-2 spike protein

Dravet syndrome

Drug induction of bile acid pathway

Dual hijack model of Vif in HIV infection

EDA signaling in hair follicle development

EGF/EGFR signaling

EGFR tyrosine kinase inhibitor resistance

EPAC1 and PKA reduction of retinal inflammation

EPO receptor signaling

ERK pathway in Huntington's disease

EV release from cardiac cells and their functional effects

Ebola virus infection in host

Ebstein-Barr virus LMP1 signaling

Ectoderm differentiation

Effect of dasatinib on the BCR-ABL signaling pathway

Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists

Effect of omega-3 PUFA on Huntington's disease pathways

Effect of progerin on genes involved in progeria

Effects of MFN2 mutation

Effects of nitric oxide

Eicosanoid metabolism via cyclooxygenases (COX)

Eicosanoid metabolism via cytochrome P450 monooxygenases pathway

Eicosanoid metabolism via lipooxygenases (LOX)

Eicosanoid synthesis

Electron transport chain: OXPHOS system in mitochondria

Embryonic stem cell pluripotency pathways

Endochondral ossification

Endochondral ossification with skeletal dysplasias

Endoderm differentiation

Endometrial cancer

Endoplasmic reticulum stress response in coronavirus infection

Endothelin pathways

Energy metabolism

Enterocyte cholesterol metabolism

Enterohepatic circulation of bile acids

Envelope proteins and their potential roles in EDMD physiopathology

Epithelial to mesenchymal transition in colorectal cancer

ErbB signaling

Estradiol regulation in porto-sinusoidal vascular disease

Estrogen metabolism

Estrogen metabolism

Estrogen receptor pathway

Estrogen signaling

Ethanol effects on histone modifications

Ethanol metabolism production of ROS by CYP2E1

Ether lipid biosynthesis

Ethylmalonic encephalopathy

Eukaryotic transcription initiation

Evolocumab mechanism to reduce LDL cholesterol

Exercise-induced circadian regulation

Extracellular vesicle-mediated signaling in recipient cells

Extracellular vesicles in the crosstalk of cardiac cells

Extrafollicular and follicular B cell activation by SARS-CoV-2

FABP4 in ovarian cancer

FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma

FGF23 signaling in hypophosphatemic rickets and related disorders

FGFR3 signaling in chondrocyte proliferation and terminal differentiation

FGFR4 p.G388R signaling

FLT3 p.Gln640SerfsTer8 signaling

FOXA2 pathway

FOXP3 in COVID-19

FTO obesity variant mechanism

Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling

Familial hyperlipidemia type 1

Familial hyperlipidemia type 2

Familial hyperlipidemia type 3

Familial hyperlipidemia type 4

Familial hyperlipidemia type 5

Familial partial lipodystrophy

Fanconi anemia

Farnesoid X receptor pathway

Farnesyl to CoQ10 metabolism

Fas ligand pathway and stress induction of heat shock proteins

Fatty acid and lipoprotein transport in hepatocytes

Fatty acid beta-oxidation

Fatty acid biosynthesis

Fatty acid omega-oxidation

Fatty acid transporters

Felbamate metabolism

Female steroid hormones in cardiomyocyte energy metabolism

Ferroptosis

Fibrin complement receptor 3 signaling

Flavan-3-ol metabolic pathway

Fluoroacetic acid toxicity

Fluoropyrimidine activity

Focal adhesion

Focal adhesion: PI3K-Akt-mTOR-signaling

Folate metabolism

Folate-alcohol and cancer pathway hypotheses

Follicle stimulating hormone (FSH) signaling

Fragile X syndrome

Frustrated phagocytosis leading to malignant pleural mesothelioma

G protein signaling

G1 to S cell cycle control

G13 signaling

GABA metabolism (aka GHB)

GABA receptor signaling

GDNF signaling

GDNF/RET signaling axis

GLP-1 from intestine and pancreas and role in glucose homeostasis

GLP-1 in pancreatic islet cells

GLP-1 secretion from intestine to portal vein

GNAQ p.R183Q drives capillary malformation

GNAQ pathways in port-wine stain

GPCRs, class A rhodopsin-like

GPCRs, class B secretin-like

GPCRs, class C metabotropic glutamate, pheromone

GPCRs, other

GPR143 in melanocytes and retinal pigment epithelium cells

GPR40 pathway

Galanin receptor pathway

Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases

Ganglio series sphingolipid metabolism

Ganglio sphingolipid metabolism

Gastric acid production

Gastric cancer network 1

Gastric cancer network 2

Gastrin signaling

Gene regulatory network modeling somitogenesis

Genes associated with the development of rheumatoid arthritis

Genes controlling nephrogenesis

Genes related to primary cilium development (based on CRISPR)

Genes targeted by miRNAs in adipocytes

Genetic causes of porto-sinusoidal vascular disease

Glial cell differentiation

Glioblastoma signaling

Glucocorticoid biosynthesis

Glucocorticoid receptor pathway

Glucose homeostasis

Glucose metabolism in triple-negative breast cancer cells

Glucuronidation

Glutathione metabolism

Glycerolipids and glycerophospholipids

Glycerophospholipid biosynthetic pathway

Glycine metabolism

Glycine metabolism, including IMDs

Glycogen synthesis and degradation

Glycolysis and gluconeogenesis

Glycolysis in senescence

Glycosaminoglycan degradation

Glycosaminoglycan synthesis in fibroblasts

Glycosphingolipid metabolism

Glycosylation and related congenital defects

Glycosylphosphatidyl inositol anchor pathway

Glyoxylate metabolism

Growth factors and hormones in beta cell proliferation

Gut-liver indole metabolism

H19, Rb-E2F1, and CDK-beta-catenin in colorectal cancer

HDAC6 interactions in the central nervous system

HIF1A and PPARG in cardiac hypertropthy

HIPK2 in kidney fibrosis

Hair follicle development: cytodifferentiation - stage 3 of 3

Hair follicle development: organogenesis - part 2 of 3

Hallmark of cancer: metastasis and epithelial-to-mesenchymal transition

Hallmark of cancer: non-mutational epigenetic reprogramming

Hallmark of cancer: sustaining proliferative signaling

Head and neck squamous cell carcinoma

Heart development

Hedgehog signaling

Hedgehog signaling

Hematopoietic stem cell differentiation

Hematopoietic stem cell gene regulation by GABP alpha/beta complex

Heme biosynthesis

Hemesynthesis defects and porphyrias

Hepatitis B infection

Hepatitis C and hepatocellular carcinoma

Hepatocyte growth factor receptor signaling

Hereditary leiomyomatosis and renal cell carcinoma pathway

Heroin metabolism

Hfe effect on hepcidin production

Hijack of ubiquitination by SARS-CoV-2

Hippo signaling regulation

Hippo-Merlin signaling dysregulation

Hippo-YAP signaling

Hippocampal synaptogenesis and neurogenesis

Histone modifications

Homologous recombination

Hormonal control of pubertal growth spurt

Host-pathogen interaction of human coronaviruses - MAPK signaling

Host-pathogen interaction of human coronaviruses - apoptosis

Host-pathogen interaction of human coronaviruses - autophagy

Host-pathogen interaction of human coronaviruses - interferon induction

Hunger and satiety

Hypertrophy model

Hypothesized pathways in pathogenesis of cardiovascular disease

Hypothetical craniofacial development pathway

Hypoxia-mediated EMT and stemness

ID signaling

IDO metabolic pathway

IL1 and megakaryocytes in obesity

IL1 signaling

IL10 anti-inflammatory signaling

IL11 signaling

IL17 signaling

IL18 signaling

IL19 signaling

IL2 signaling

IL26 signaling

IL3 signaling

IL4 signaling

IL5 signaling

IL6 signaling

IL7 signaling

IL9 signaling

Imatinib and chronic myeloid leukemia

Immune infiltration in pancreatic cancer

Immune response to tuberculosis

Inclusion body myositis

Induction of autophagy and toll-like receptor signaling by graphene oxide

Inflammatory bowel disease signaling

Inflammatory response pathway

Influence of laminopathies on Wnt signaling

Influenza A virus infection

Inhibition of GNAQ-regulated signaling in uveal melanoma

Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells

Initiation of transcription and translation elongation at the HIV-1 LTR

Insulin signaling

Insulin signaling in adipocytes (diabetic condition)

Insulin signaling in adipocytes (normal condition)

Integrated breast cancer pathway

Integrated cancer pathway

Integrin-mediated cell adhesion

Interactions between LOXL4 and oxidative stress pathway

Interactions between immune cells and microRNAs in tumor microenvironment

Interactions of natural killer cells in pancreatic cancer

Interactome of polycomb repressive complex 2 (PRC2)

Interferon type I signaling

Interferon-mediated signaling

Interleukin-1 (IL-1) structural pathway

Interleukin-1 induced activation of NF-kB

Intracellular trafficking proteins involved in CMT neuropathy

Intraflagellar transport proteins binding to dynein

Involvement of δ-secretase in neurodegenerative diseases

Irinotecan pathway

Iron metabolism disorders

Iron metabolism in placenta

Iron-sulfur cluster biogenesis

Isoglobo series sphingolipids

JAK-STAT signaling in the regulation of beta cells

Joubert syndrome

KCNQ2-related epilepsies

Kallmann syndrome

Kennedy pathway from sphingolipids

Ketogenesis and ketolysis

Kinin-Kallikrein pathway

Kisspeptin/kisspeptin receptor system in the ovary

Kit receptor signaling

Kleefstra syndrome

Krebs cycle disorders

Kynurenine pathway and links to cell senescence

LDL- influence on CD14 and TLR4

LDLRAD4 and what we know about it

LTF danger signal response pathway

Lac-Phe pathway

Lactate shuttle in glial cells

Lacto series sphingolipid metabolism

Lamin A processing pathway

Leptin and adiponectin

Leptin signaling

Leptin-insulin signaling overlap

Leucine, isoleucine and valine metabolism

Leukocyte-intrinsic Hippo pathway functions

Leukotriene metabolic pathway

Lidocaine metabolism

Linoleic acid metabolism affected by SARS-CoV-2

Linoleic acid oxylipin metabolism

Lipid metabolism in senescent cells

Lipid metabolism pathway

Lipid particles composition

Liver X receptor pathway

Liver steatosis adverse outcome pathway

Lung fibrosis

Lung pathology of COVID-19

MAP3K1 role in promoting and blocking gonadal determination

MAPK and NFkB signaling inhibited by Yersinia YopJ

MAPK cascade

MAPK pathway in congenital thyroid cancer

MAPK signaling

MECP2 and associated Rett syndrome

MET in type 1 papillary renal cell carcinoma

MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement

MFAP5-mediated ovarian cancer cell motility and invasiveness

MTHFR deficiency

MYD88 distinct input-output pathway

Macrophage markers

Macrophage-stimulating protein (MSP) signaling

Major receptors targeted by epinephrine and norepinephrine

Malate-aspartate shuttle

Male infertility

Male steroid hormones in cardiomyocyte energy metabolism

Mammalian disorder of sexual development

Mammary gland development: embryonic development - stage 1 of 4

Mammary gland development: involution - stage 4 of 4

Mammary gland development: pregnancy and lactation - stage 3 of 4

Mammary gland development: puberty - stage 2 of 4

Markers of kidney cell lineage

Matrix metalloproteinases

Measles virus infection

Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms

Melanoma

Melatonin metabolism and effects

Mesodermal commitment pathway

Meta pathway lipodystrophy, dyslipidemia and hyperlipidemia

Metabolic epileptic disorders

Metabolic pathway of LDL, HDL and TG, including diseases

Metabolic pathways of fibroblasts

Metabolic reprogramming in colon cancer

Metabolic reprogramming in pancreatic cancer

Metabolism of alpha-linolenic acid

Metabolism of dichloroethylene by CYP450

Metabolism of sphingolipids in ER and Golgi apparatus

Metabolism of tetrahydrocannabinol (THC)

Metabolism overview

Metapathway biotransformation Phase I and II

Metastatic brain tumor

Methionine de novo and salvage pathway

Methionine metabolism leading to sulfur amino acids and related disorders

Methylation pathways

Mevalonate arm of cholesterol biosynthesis pathway

Mevalonate arm of cholesterol biosynthesis pathway with inhibitors

Mevalonate pathway

MicroRNA for targeting cancer growth and vascularization in glioblastoma

MicroRNA network associated with chronic lymphocytic leukemia

MicroRNAs in cardiomyocyte hypertrophy

Microglia pathogen phagocytosis pathway

Microtubule cytoskeleton regulation

Mineralocorticoid biosynthesis

Mitochondrial beta-oxidation

Mitochondrial carrier deficiency associated with shuttle disturbances

Mitochondrial complex I assembly model OXPHOS system

Mitochondrial complex I inhibition leading to chemical-induced Fanconi syndrome

Mitochondrial complex I inhibition leading to parkinsonian motor deficits

Mitochondrial complex II assembly

Mitochondrial complex III assembly

Mitochondrial complex IV assembly

Mitochondrial complex inhibition leading to liver injury

Mitochondrial fatty acid oxidation disorders

Mitochondrial fatty acid synthesis pathway

Mitochondrial fission and fusion

Mitochondrial gene expression

Mitochondrial immune response to SARS-CoV-2

Mitochondrial long chain fatty acid beta-oxidation

Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors

Modified nucleosides derived from tRNA as urinary cancer markers

Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids

Modulators of TCR signaling and T cell activation

Molecular pathway for oxidative stress

Molybdenum cofactor (Moco) biosynthesis

Monoamine GPCRs

Monoamine transport

Multiple epiphyseal dysplasia and pseudoachondroplasia genes

Myometrial relaxation and contraction pathways

N-glycan biosynthesis

NAD biosynthesis II from tryptophan

NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence

NAD metabolism, sirtuins and aging

NAD+ biosynthetic pathways

NAD+ metabolism

NF1 copy number variation syndrome

NIPBL role in DNA damage - Cornelia de Lange syndrome

NO/cGMP/PKG mediated neuroprotection

NOTCH1 regulation of endothelial cell calcification

NPHP1 deletion syndrome

NRF2 pathway

NRF2-ARE regulation

NRP1-triggered signaling in pancreatic cancer

NRXN1 deletion syndrome

Nanomaterial induced apoptosis

Nanomaterial-induced inflammasome activation

Nanoparticle triggered autophagic cell death

Nanoparticle triggered regulated necrosis

Nanoparticle-mediated activation of receptor signaling

Neolacto series sphingolipid metabolism

Neovascularization processes

Nephrogenesis

Nephrotic syndrome

Nephrotoxcicity adverse outcome pathway

Netrin-UNC5B signaling

Network map of SARS-CoV-2 signaling

Neural crest cell migration during development

Neural crest cell migration in cancer

Neural crest differentiation

Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway

Neurogenesis regulation in the olfactory epithelium

Neuroinflammation

Neuroinflammation and glutamatergic signaling

Neurotransmitter disorders

Nicotine effect on chromaffin cells

Nicotine effect on dopaminergic neurons

Nicotine metabolism in liver cells

Nitric oxide metabolism in cystic fibrosis

Nod-like receptor (NLR) signaling

Non-classical role of vitamin D

Non-genomic actions of 1,25-dihydroxyvitamin D3

Non-homologous end joining

Non-small cell lung cancer

Nonalcoholic fatty liver disease

Notch signaling

Notch signaling

Novel intracellular components of RIG-I-like receptor pathway

Nuclear receptors

Nuclear receptors in lipid metabolism and toxicity

Nuclear receptors meta-pathway

Nucleotide GPCRs

Nucleotide excision repair

Nucleotide excision repair in xeroderma pigmentosum

Nucleotide-binding oligomerization domain (NOD) pathway

OSX and miRNAs in tooth development

Octadecanoid formation from linoleic acid

Oligodendrocyte specification and differentiation, leading to myelin components for CNS

Omega-3 / omega-6 fatty acid synthesis

Omega-3-fatty acids in senescence

Omega-6-fatty acids in senescence

Omega-9 fatty acid synthesis

Oncostatin M signaling

One-carbon metabolism

Ophthalmate biosynthesis in hepatocytes

Opioid receptor pathways

Orexin receptor pathway

Osteoarthritic chondrocyte hypertrophy

Osteoblast differentiation and related diseases

Osteoblast signaling

Osteoclast signaling

Osteopontin signaling

Ovarian infertility

Overlap between signal transduction pathways contributing to LMNA laminopathies

Overview of nanoparticle effects

Overview of proinflammatory and profibrotic mediators

Oxidation by cytochrome P450

Oxidative damage response

Oxidative phosphorylation

Oxidative stress in pulmonary tissue

Oxidative stress response

Oxysterols derived from cholesterol

Oxytocin signaling

PAFAH1B1 copy number variation

PCSK9-mediated LDL receptor degradation

PDGF pathway

PDGFR-beta pathway

PGK1, PKM2, KHKC/KHKA acting as protein kinases

PI3K-AKT-mTOR signaling and therapeutic opportunities in prostate cancer

PI3K-Akt signaling

PI3K/AKT/mTOR - vitamin D3 signaling

PKC-gamma calcium signaling in ataxia

PPAR signaling

PPAR-alpha pathway

PTF1A related regulatory pathway

Pancreatic adenocarcinoma pathway

Pancreatic cancer subtypes

Parkin-ubiquitin proteasomal system pathway

Parkinson's disease pathway

Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex

Pathogenic Escherichia coli infection

Pathophysiological roles of DUX4 in FSHD1

Pathways affected in adenoid cystic carcinoma

Pathways into methionine and folate cycles

Pathways of nucleic acid metabolism and innate immune sensing

Pentose phosphate metabolism

Pentose phosphate pathway in senescent cells

Peptide GPCRs

Peroxiredoxin 2 induced ovarian failure

Peroxisomal beta-oxidation of tetracosanoyl-CoA

Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins

Phase I biotransformations, non-P450

Phosphatidyl inositol phosphate pathway

Phosphatidylcholine catabolism

Phosphodiesterases in neuronal function

Phosphoinositide 3-kinase (PI3K) family

Phosphoinositides metabolism

Photodynamic therapy-induced AP-1 survival signaling

Photodynamic therapy-induced HIF-1 survival signaling

Photodynamic therapy-induced NF-kB survival signaling

Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling

Photodynamic therapy-induced unfolded protein response

Physico-chemical features and toxicity-associated pathways

Physiological and pathological hypertrophy of the heart

Pilocytic astrocytoma

Platelet-mediated interactions with vascular and circulating cells

Pleural mesothelioma

Pluripotent stem cell differentiation pathway

Polycystic kidney disease pathway

Polyol pathway

Post-COVID neuroinflammation

Prader-Willi and Angelman syndrome

Pre-implantation embryo

Pregnane X receptor pathway

Primary focal segmental glomerulosclerosis (FSGS)

Primary ovarian insufficiency

Primary ovarian insufficiency

Prion disease pathway

Pro-survival signaling of neuroprotectin D1

Progeria-associated lipodystrophy

Prolactin signaling

Proline and hydroxyproline pathways

Prostaglandin and leukotriene metabolism in senescence

Prostaglandin and leukotriene metabolism in senescence

Prostaglandin signaling

Prostaglandin synthesis and regulation

Proteasome degradation

Protein alkylation leading to liver fibrosis

Proteoglycan biosynthesis

Proximal tubule transport

PtdIns(4,5)P2 in cytokinesis pathway

Purine metabolism

Purine metabolism and related disorders

Purinergic signaling

Pyrimidine metabolism

Pyrimidine metabolism and related diseases

Quercetin and Nf-kB / AP-1 induced apoptosis

RAC1/PAK1/p38/MMP2 pathway

RANKL/RANK signaling

RAS and bradykinin pathways in COVID-19

RIOK1 and RIOK2 in EGFR- and PI3K-mediated tumorigenesis

ROBO4 and VEGF signaling crosstalk

ROS in COVID-19 endothelial dysfunction

RalA downstream regulated genes

Ras signaling

Receptor tyrosine kinase (RTK) family

Regucalcin in proximal tubule epithelial kidney cells

Regulation of Wnt / B-catenin signaling by small molecule compounds

Regulation of actin cytoskeleton

Regulation of apoptosis by parathyroid hormone-related protein

Regulation of cytotoxic T cell responses by Malat1 - miR-15/16 circuit

Regulation of sister chromatid separation at the metaphase-anaphase transition

Regulatory circuits of STAT3 signaling

Relationship between inflammation, COX-2 and EGFR

Renin-angiotensin-aldosterone system (RAAS)

Resistin as a regulator of inflammation

Resolvin E1 and resolvin D1 signaling decrease inflammation

Retinoblastoma gene in cancer

Retinol metabolism

Rett syndrome

Riboflavin and CoQ disorders

Role of carnosine in muscle contraction

Roles of ceramides in development of insulin resistance

Rubinstein-Taybi syndrome 1

S1P receptor signal transduction

SARS coronavirus and innate immunity

SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation

SARS-CoV-2 altering angiogenesis via NRP1

SARS-CoV-2 and ACE2 receptor: molecular mechanisms

SARS-CoV-2 and COVID-19 pathway

SARS-CoV-2 innate immunity evasion and cell-specific immune response

SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction

SARS-CoV-2 replication organelle formation

SCFA and skeletal muscle substrate metabolism

SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome

SREBF and miR33 in cholesterol and lipid homeostasis

SRF and miRs in smooth muscle differentiation and proliferation

STING pathway in Kawasaki-like disease and COVID-19

Sebaleic acid formation and metabolism

Secretion of hydrochloric acid in parietal cells

Selective expression of chemokine receptors during T-cell polarization

Selenium metabolism and selenoproteins

Selenium micronutrient network

Senescence-associated secretory phenotype (SASP)

Serine metabolism

Serotonin HTR1 group and FOS pathway

Serotonin and anxiety

Serotonin and anxiety-related events

Serotonin receptor 2 and ELK-SRF/GATA4 signaling

Serotonin receptor 4/6/7 and NR3C signaling

Serotonin transporter activity

Sialylation

Signal transduction through IL1R

Sildenafil treatment

Sleep regulation

Small cell lung cancer

Small ligand GPCRs

Smith-Magenis and Potocki-Lupski syndrome copy number variation

Soluble ACE2-mediated cell entry of SARS-CoV-2

Somatic sex determination

Somatroph axis (GH) and its relationship to dietary restriction and aging

Somitogenesis in the context of spondylocostal dysostosis

Sphingolipid metabolism in senescence

Sphingolipid metabolism overview

Sphingolipid metabolism: integrated pathway

Sphingolipid pathway

Spina bifida

Spinal cord injury

Splicing factor NOVA regulated synaptic proteins

Statin inhibition of cholesterol production

Steroid biosynthesis

Steroid hormone precursor biosynthesis

Steroidogenic pathway

Sterol regulatory element-binding proteins (SREBP) signaling

Striated muscle contraction pathway

Sudden infant death syndrome (SIDS) susceptibility pathways

Sulfatase and aromatase pathway

Sulfation biotransformation reaction

Sulindac metabolic pathway

Suppression of HMGB1-mediated inflammation by THBD

Synaptic signaling associated with autism spectrum disorder

Synaptic vesicle pathway

Synthesis of ceramides and 1-deoxyceramides

T cell modulation in pancreatic cancer

T cell receptor and co-stimulatory signaling

T-cell activation SARS-CoV-2

T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection

T-cell receptor signaling

TAR syndrome

TCA cycle (aka Krebs or citric acid cycle)

TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc)

TCA cycle in senescence

TCA cycle nutrient use and invasiveness of ovarian cancer

TGF-beta receptor signaling

TGF-beta receptor signaling in skeletal dysplasias

TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition

TGF-beta signaling pathway

TGFB / Smad signaling

TLR4 signaling and tolerance

TNF-alpha signaling

TNF-related weak inducer of apoptosis (TWEAK) signaling

TP53 network

TROP2 regulatory signaling

TYROBP causal network in microglia

Tamoxifen metabolism

Target of rapamycin signaling

Targeted agents in triple negative breast cancer

Targeted therapy in breast cancer

Targeting YAP in pancreatic ductal adenocarcinoma (PDAC)

Tgif disruption of Shh signaling

Th17 cell differentiation pathway

Thermogenesis

Thiamine metabolic pathways

Thymic stromal lymphopoietin (TSLP) signaling

Thyroid hormone imbalance leading to neurodevelopmental abnormalities

Thyroid hormones production and peripheral downstream signaling effects

Thyroid stimulating hormone (TSH) signaling

Thyroxine (thyroid hormone) production

Toll-like receptor signaling

Toll-like receptor signaling related to MyD88

Trans-sulfuration pathway

Trans-sulfuration, one-carbon metabolism and related pathways

Transcription co-factors SKI and SKIL protein partners

Transcription factor regulation in adipogenesis

Transcription factors regulate miRNAs related to cardiac hypertrophy

Transcriptional activation by NRF2 in response to phytochemicals

Transcriptional cascade regulating adipogenesis

Transcriptional regulation of memory B cell differentiation

Translation factors

Translation inhibitors in chronically activated PDGFRA cells

Triacylglyceride synthesis

Tryptophan catabolism leading to NAD+ production

Tryptophan metabolism

Tumor suppressor activity of SMARCB1

Type 2 papillary renal cell carcinoma

Type I collagen synthesis in the context of osteogenesis imperfecta

Type I interferon induction and signaling during SARS-CoV-2 infection

Type II diabetes mellitus

Type II interferon signaling

Type III interferon signaling

Tyrosine kinase inhibitors in glioblastoma

Tyrosine metabolism and related disorders

UDP-derived sugars synthesis in fibroblasts

Ulcerative colitis signaling

Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer

Unfolded protein response

Urea cycle and associated pathways

Urea cycle and metabolism of amino groups

Urea cycle and related diseases

Urotensin-II-mediated signaling

VEGFA-VEGFR2 signaling

Valproic acid pathway

Vasopressin-regulated water reabsorption

Vitamin A and carotenoid metabolism

Vitamin A1 and A5/X pathways

Vitamin B12 disorders

Vitamin B12 metabolism

Vitamin B6-dependent and responsive disorders

Vitamin D in inflammatory diseases

Vitamin D metabolism

Vitamin D receptor pathway

Vitamin D-sensitive calcium signaling in depression

Vitamin K metabolism and activation of dependent proteins

Vitamins A and D - action mechanisms

Warburg effect modulated by deubiquitinating enzymes and their substrates

White fat cell differentiation

Wnt signaling

Wnt signaling

Wnt signaling and pluripotency

Wnt signaling in kidney disease

Wnt/Beta-catenin signaling inhibitors in current and past clinical trials

Wnt/beta-catenin signaling in leukemia

Zinc homeostasis

eIF5A regulation in response to inhibition of the nuclear export system

exRNA mechanism of action and biogenesis

let-7 inhibition of ES cell reprogramming

lncRNA in canonical Wnt signaling and colorectal cancer

lncRNA-mediated mechanisms of therapeutic resistance

mBDNF and proBDNF regulation of GABA neurotransmission

mRNA processing

mRNA vaccine activation of dendritic cell and induction of IFN-1

mRNA, protein, and metabolite inducation pathway by cyclosporin A

miR-222 in exercise-induced cardiac growth

miR-509-3p alteration of YAP1/ECM axis

miR-517 relationship with ARCN1 and USP1

miR-targeted genes in adipocytes

miR-targeted genes in leukocytes

miR-targeted genes in lymphocytes

miR-targeted genes in muscle cell

miR-targeted genes in squamous cell

miRNA biogenesis

miRNA degrading enzymes

miRNA regulation of DNA damage response

miRNA regulation of p53 pathway in prostate cancer

miRNA regulation of prostate cancer signaling

miRNA role in immune response in sepsis

miRNA targets in ECM and membrane receptors

miRNAs involved in DNA damage response

mir-124 predicted interactions with cell cycle and differentiation

ncRNAs in Wnt signaling in hepatocellular carcinoma

ncRNAs involved in STAT3 signaling in hepatocellular carcinoma

nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell

p38 MAPK signaling

p53 transcriptional gene network