Leukocyte-intrinsic Hippo pathway functions (WP4542)

Homo sapiens

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The Hippo signaling pathway can regulate T lymphocyte proliferation and survival, giving rise to implications for cancer and immunology. Solid lines: direct interactions Dotted lines: indirect (or not fully delineated) mechanisms

Authors

Anders Riutta , Marvin Martens , Elisson nl , Friederike Ehrhart , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

leukocyte T cell

Pathway Ontology

Hippo signaling pathway immune response pathway

Disease Ontology

cancer

Participants
Query Drugst.One

Label Type Compact URI Comment
integrins GeneProduct pfam:PF08441
YAP GeneProduct ncbigene:10413
YWHAQ GeneProduct ncbigene:10971 14-3-3
TAZ GeneProduct ncbigene:6901 YAP/TAZ
YAP1 GeneProduct ncbigene:10413
LATS1 GeneProduct ncbigene:9113 LATS1)
LATS2 GeneProduct ncbigene:26524
MOB1 GeneProduct ncbigene:55233
MST1 GeneProduct ncbigene:4485 MST1/2
MST2 GeneProduct ncbigene:6788
SAV1 GeneProduct ncbigene:60485
NDR1 GeneProduct ncbigene:10397
NDR2 GeneProduct ncbigene:23012
FOXO6 GeneProduct ncbigene:100132074 FOXO
FOXO4 GeneProduct ncbigene:4303 FOXO
FOXO1 GeneProduct ncbigene:2308 FOXO
FOXO3 GeneProduct ncbigene:2309 FOXO
FOXP3 GeneProduct ncbigene:50943 FoxP3
TEAD1 GeneProduct ncbigene:7003
RAP GeneProduct ncbigene:83593
RAPL GeneProduct ncbigene:83593
Rac1 GeneProduct ncbigene:5879
Kindlin-3 GeneProduct ncbigene:83706
SKAP GeneProduct ncbigene:90417
ADAP GeneProduct ncbigene:2533
RAB13 GeneProduct ncbigene:5872 Rab13
Blimp1 GeneProduct ncbigene:639
RAP1 GeneProduct ncbigene:5906
RHOA GeneProduct ncbigene:387 RhoA
CCR7 GeneProduct ncbigene:1236 CCR7)
CD19 GeneProduct ncbigene:930
BLIMP1 GeneProduct ncbigene:639
NORE1B GeneProduct ncbigene:83593
miR-21 GeneProduct ncbigene:406991
LPL GeneProduct ncbigene:4023 LPL
p38MAPK GeneProduct ncbigene:1432
LFA-1 GeneProduct ncbigene:3683
FOXP3 GeneProduct ncbigene:50943 FOXO
TEAD2 GeneProduct ncbigene:8463
TEAD3 GeneProduct ncbigene:7005
TEAD4 GeneProduct ncbigene:7004

References

  1. The Hippo Pathway: Immunity and Cancer. Taha Z, Janse van Rensburg HJ, Yang X. Cancers (Basel). 2018 Mar 28;10(4):94. PubMed Europe PMC Scholia