Clock-controlled autophagy in bone metabolism (WP5205)

Homo sapiens

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
This integrated pathway shows cross-talk among circadian rhythm, autophagy and osteoclast/osteoblast differentiation pathways. Other pathways are shown as activators and/or inhibitors of the bone remodeling process.

Authors

Haseena Noureen , Kristina Hanspers , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

osteocyte osteoclast osteoblast

Pathway Ontology

autophagy pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
S1P Metabolite chebi:37550
BMP Metabolite chebi:60815
CLOCK GeneProduct ensembl:ENSG00000134852
ARNTL GeneProduct ensembl:ENSG00000133794
PER1 GeneProduct ensembl:ENSG00000179094
CRY1 GeneProduct ensembl:ENSG00000008405
MTOR GeneProduct ensembl:ENSG00000198793
ULK1 GeneProduct ensembl:ENSG00000177169
ATG13 GeneProduct ensembl:ENSG00000175224
NFATC1 GeneProduct ensembl:ENSG00000131196
ATG5 GeneProduct ensembl:ENSG00000057663
ATG16L1 GeneProduct ensembl:ENSG00000085978
ATG12 GeneProduct ensembl:ENSG00000145782
BECN1 GeneProduct ensembl:ENSG00000126581
RANKL GeneProduct ensembl:ENSG00000141655
RB1CC1 GeneProduct ensembl:ENSG00000023287
PIK3C3 GeneProduct ensembl:ENSG00000078142
ATG101 GeneProduct ensembl:ENSG00000123395
OPG GeneProduct ensembl:ENSG00000164761
RANK GeneProduct ensembl:ENSG00000120659
AMBRA1 GeneProduct ensembl:ENSG00000110497
CTSK GeneProduct ensembl:ENSG00000143387
P115 GeneProduct ensembl:ENSG00000089820
SMAD8 GeneProduct ensembl:ENSG00000120693
SMAD5 GeneProduct ensembl:ENSG00000113658
SMAD1 GeneProduct ensembl:ENSG00000170365
AMPK GeneProduct ensembl:ENSG00000162409
BMP1 GeneProduct ensembl:ENSG00000125845
LAMP2 GeneProduct ensembl:ENSG00000005893
WNT16 GeneProduct ensembl:ENSG00000002745
SEMA3A GeneProduct ensembl:ENSG00000075213
WNT5A GeneProduct ensembl:ENSG00000114251
TRAP GeneProduct ensembl:ENSG00000126602
MAP1LC3A GeneProduct ensembl:ENSG00000101460
MAP1LC3B GeneProduct ensembl:ENSG00000140941
IGF1 GeneProduct ensembl:ENSG00000017427
DKK1 GeneProduct ensembl:ENSG00000107984
SEMA4D GeneProduct ensembl:ENSG00000187764
WNT10B GeneProduct ensembl:ENSG00000169884
CTHRC1 GeneProduct ensembl:ENSG00000164932
EFNB2 GeneProduct ensembl:ENSG00000125266
CT-1 GeneProduct ensembl:ENSG00000150281
TGFB1 GeneProduct ensembl:ENSG00000105329
RUNX2 GeneProduct ensembl:ENSG00000124813
LEP GeneProduct ensembl:ENSG00000174697
RORB GeneProduct ensembl:ENSG00000198963
NPAS2 GeneProduct ensembl:ENSG00000170485
NR1D2 GeneProduct ensembl:ENSG00000174738
BHLHE40 GeneProduct ensembl:ENSG00000134107
BHLHE41 GeneProduct ensembl:ENSG00000123095
NOTCH1 GeneProduct ensembl:ENSG00000148400
BCL2 GeneProduct ensembl:ENSG00000171791
VCP GeneProduct ensembl:ENSG00000165280
FYCO1 GeneProduct ensembl:ENSG00000163820
PLEKHM1 GeneProduct ensembl:ENSG00000225190
DRAM2 GeneProduct ensembl:ENSG00000156171
BMP2 GeneProduct ensembl:ENSG00000152785
BMP4 GeneProduct ensembl:ENSG00000125378
BMPR2 GeneProduct ensembl:ENSG00000204217
BMP5 GeneProduct ensembl:ENSG00000112175
BMP6 GeneProduct ensembl:ENSG00000153162
CALCA GeneProduct ensembl:ENSG00000110680
SMAD4 GeneProduct ensembl:ENSG00000141646
SERPINF1 GeneProduct ensembl:ENSG00000132386
PTH GeneProduct ensembl:ENSG00000152266
CSF1 GeneProduct ensembl:ENSG00000184371
JAK2 GeneProduct ensembl:ENSG00000096968
LRP5 GeneProduct ensembl:ENSG00000162337
CHRD GeneProduct ensembl:ENSG00000090539
MEPE GeneProduct ensembl:ENSG00000152595
AKT1 GeneProduct ensembl:ENSG00000142208
ATG10 GeneProduct ensembl:ENSG00000152348
HMGB1 GeneProduct ensembl:ENSG00000189403
SQSTM1 GeneProduct ensembl:ENSG00000161011
IL3 GeneProduct ensembl:ENSG00000164399
IL6 GeneProduct ensembl:ENSG00000136244
ATG7 GeneProduct ensembl:ENSG00000197548
SOST GeneProduct ensembl:ENSG00000167941
ATG4C GeneProduct ensembl:ENSG00000125703
ATG3 GeneProduct ensembl:ENSG00000144848
IL3,6,7 GeneProduct ensembl:ENSG00000164399
TRAF6 GeneProduct ensembl:ENSG00000175104
BMP7 GeneProduct ensembl:ENSG00000153162
Rev-Erb GeneProduct ensembl:ENSG00000008405
MMP9 GeneProduct ensembl:ENSG00000008405
CX3CR1 GeneProduct ensembl:ENSG00000008405
IL1/4/6/7 GeneProduct ensembl:ENSG00000120659
TNF-a GeneProduct ensembl:ENSG00000120659
WNT6 GeneProduct ensembl:ENSG00000114251
WNT10a GeneProduct ensembl:ENSG00000114251
SP7 GeneProduct ensembl:ENSG00000170374
ATG4 GeneProduct ensembl:ENSG00000197548

References

  1. Gremlin, Noggin, Chordin and follistatin differentially modulate BMP induced suppression of androgen secretion by bovine ovarian theca cells. Glister C, Regan SL, Samir M, Knight P. J Mol Endocrinol. 2018 Oct 1;JME-18-0198.R1. PubMed Europe PMC Scholia