Interferon-mediated signaling (WP4558)
Homo sapiens
Interferons (IFNs) can be devided in three classes, Type I, II and III. Type I IFNs are created when the cell surface or specific receptors recognize microbial products; these are structural homologues of one another which bind the same receptor. Binding to this receptor leads to an activation of kinases which regulate the phosphorylation and therefore activation of some STAT proteins (see PW for details). There is only 1 Type II interferon, INF-gamma, consisting of two subunits (R1 and R2), which associate with Jak 1 and 2, respectively. Activation of Jak1 and Jak2 leads to phosphorylation of STAT1, which ultimately binds to IFN-gamma-activated sequence (GAS) elements, regulating the transcription of genes. Type III interferons are considered a protein family of 4, which bind to a different receptor compared to Type I interferons, however they trigger the same STAT1+2 phosphorylation reactions as TypeI IFNs.
Authors
Paul Rgnier , Andra Waagmeester , Denise Slenter , Kristina Hanspers , and Eric WeitzActivity
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Cited In
- A Chinese host genetic study discovered IFNs and causality of laboratory traits on COVID-19 severity (2021).
- Combination of Enrichment Using Gene Ontology and Transcriptomic Analysis Revealed Contribution of Interferon Signaling to Severity of COVID-19 (2022).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
type II interferon signaling pathway signaling pathway type I interferon signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| JAK1 | GeneProduct | ncbigene:3716 | |
| TYK2 | GeneProduct | ncbigene:7297 | |
| JAK2 | GeneProduct | ncbigene:3717 | |
| STAT1 | GeneProduct | ncbigene:6772 | |
| STAT2 | GeneProduct | ncbigene:6773 | |
| PIK3R1 | GeneProduct | ncbigene:5295 | |
| PIK3CA | GeneProduct | ncbigene:5290 | |
| PRKCA | GeneProduct | ncbigene:5578 | |
| IRF9 | GeneProduct | ncbigene:10379 | |
| IFNAR2 | GeneProduct | ncbigene:3455 | |
| IFNAR1 | GeneProduct | ncbigene:3454 | |
| IFNGR1 | GeneProduct | ncbigene:3459 | |
| IFNGR2 | GeneProduct | ncbigene:3460 | |
| IFNA1 | GeneProduct | ncbigene:3439 | |
| IFNA7 | GeneProduct | ncbigene:3444 | |
| IFNG | GeneProduct | ncbigene:3458 | |
| IFNLR1 | GeneProduct | ncbigene:163702 | |
| IL10RB | GeneProduct | ncbigene:3588 | |
| IFNL1 | GeneProduct | ncbigene:282618 | |
| IFNL2 | GeneProduct | ncbigene:282616 | |
| IFNL3 | GeneProduct | ncbigene:282617 | |
| IFNL4 | GeneProduct | ncbigene:101180976 | |
| IFNA5 | GeneProduct | ncbigene:3442 | |
| IFNA6 | GeneProduct | ncbigene:3443 | |
| IFNA4 | GeneProduct | ncbigene:3441 | |
| IFNA2 | GeneProduct | ncbigene:3440 | |
| IFNA8 | GeneProduct | ncbigene:3445 | |
| IFNA10 | GeneProduct | ncbigene:3446 | |
| IFNA13 | GeneProduct | ncbigene:3447 | |
| IFNA14 | GeneProduct | ncbigene:3448 | |
| IFNA16 | GeneProduct | ncbigene:3449 | |
| IFNA17 | GeneProduct | ncbigene:3451 | |
| IFNA21 | GeneProduct | ncbigene:3452 | |
| IFNB1 | GeneProduct | ncbigene:3456 | |
| IFNE | GeneProduct | ncbigene:338376 | |
| IFNW1 | GeneProduct | ncbigene:3467 | |
| IFNK | GeneProduct | ncbigene:56832 |
References
- Mechanisms of type-I- and type-II-interferon-mediated signalling. Platanias LC. Nat Rev Immunol. 2005 May;5(5):375–86. PubMed Europe PMC Scholia
- Direct effects of type I interferons on cells of the immune system. Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I. Clin Cancer Res. 2011 May 1;17(9):2619–27. PubMed Europe PMC Scholia
- Decoding type I and III interferon signalling during viral infection. Mesev EV, LeDesma RA, Ploss A. Nat Microbiol. 2019 Jun;4(6):914–24. PubMed Europe PMC Scholia