Hfe effect on hepcidin production (WP3924)

Homo sapiens

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new pathway, converted from mouse WP3673

Authors

Kristina Hanspers and Alex Pico

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

regulatory pathway iron homeostasis pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
HFE GeneProduct ensembl:ENSG00000010704 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000006611
TMPRSS6 GeneProduct ensembl:ENSG00000187045 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000016942
HFE2 GeneProduct ensembl:ENSG00000168509
HAMP GeneProduct ensembl:ENSG00000105697 Hepcidin. Inhibits iron absorbtion
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000050440
BMP6 GeneProduct ensembl:ENSG00000153162 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000039004
SMAD7 GeneProduct ensembl:ENSG00000101665 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000025880
ID1 GeneProduct ensembl:ENSG00000125968 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000042745

References

  1. Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice. Finberg KE, Whittlesey RL, Andrews NC. Blood. 2011 Apr 28;117(17):4590–9. PubMed Europe PMC Scholia