Canonical NF-kB pathway (WP4562)

Homo sapiens

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The canonical NF-KB pathway is induced by the ligand-dependent activation of a variety of receptors. Stimulus-dependent activation of the IKK complex results in the phosphorylation and subsequent proteasomal degradation of IκBα and IκBε (NFKBIA and NFKBIE). This allows the nuclear translocation of transcriptionally active RelA/p50 (RELA, NFKB1) or c-Rel/p50 heterodimers (REL, NFKB1).

Authors

Martina Summer-Kutmon , Alex Pico , and Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

nuclear factor kappa B signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
RELA GeneProduct ensembl:ENSG00000173039 RelA
NFKBIA GeneProduct ensembl:ENSG00000100906
REL GeneProduct ensembl:ENSG00000162924 c-Rel
NFKB1 GeneProduct ensembl:ENSG00000109320
NFKBIE GeneProduct ensembl:ENSG00000146232
CHUK GeneProduct ensembl:ENSG00000213341 IKKa
IKBKB GeneProduct ensembl:ENSG00000104365
IKBKG GeneProduct ensembl:ENSG00000269335 IKKy

References

  1. NF-κB Activation in Lymphoid Malignancies: Genetics, Signaling, and Targeted Therapy. Grondona P, Bucher P, Schulze-Osthoff K, Hailfinger S, Schmitt A. Biomedicines. 2018 Mar 26;6(2):38. PubMed Europe PMC Scholia