FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma (WP4553)

Homo sapiens

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FBXL10, a member of Polycomb repressive complexes, is overexpressed in human diffuse large B-cell lymphoma tissues and cell lines. FBXL10 silences the expression of DUSP6 through recruitment of polycomb repressuive complexes, which leads to the deposition of repressive histone modifications in the DUPS6 promoter. DUSP6 is a ERK1/2 (MAPK1/MAPK3) phosphatase and with lower levels of DUSP6, ERK1/2 remain phosphorylated and thus activates downstream ERK/MAPK signaling and ultimately cell proliferation. Based on figure 7 in [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833345/ Zhao et al]

Authors

Kristina Hanspers and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

CPTAC Diseases

Annotations

Disease Ontology

diffuse large B-cell lymphoma disease of cellular proliferation

Cell Type Ontology

B cell

Pathway Ontology

altered extracellular signal-regulated Raf/Mek/Erk signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
H2AFB1 GeneProduct ensembl:ENSG00000274183
H2AFB2 GeneProduct ensembl:ENSG00000277858
MAPK1 GeneProduct ncbigene:5594
MAPK3 GeneProduct ncbigene:5595
DUSP6 GeneProduct ensembl:ENSG00000139318
EED GeneProduct ensembl:ENSG00000074266
EZH2 GeneProduct ensembl:ENSG00000106462
SUZ12 GeneProduct ensembl:ENSG00000178691
PCGF1 GeneProduct ensembl:ENSG00000115289
BCOR GeneProduct ensembl:ENSG00000183337
FBXL10 GeneProduct ensembl:ENSG00000089094
BCL6 GeneProduct ensembl:ENSG00000113916
RNF2 GeneProduct ensembl:ENSG00000121481
H3F3A GeneProduct ensembl:ENSG00000163041
H3F3B GeneProduct ensembl:ENSG00000132475
HIST1H3D GeneProduct ensembl:ENSG00000197409
HIST1H3J GeneProduct ensembl:ENSG00000197153
HIST2H3A GeneProduct ensembl:ENSG00000203852
HIST2H3C GeneProduct ensembl:ENSG00000203811
HIST2H3D GeneProduct ensembl:ENSG00000183598
HIST1H3C GeneProduct ensembl:ENSG00000278272
HIST1H3G GeneProduct ensembl:ENSG00000273983
HIST1H3H GeneProduct ensembl:ENSG00000278828
HIST1H3A GeneProduct ensembl:ENSG00000275714
HIST1H3F GeneProduct ensembl:ENSG00000277775
HIST1H3B GeneProduct ensembl:ENSG00000274267
HIST1H3I GeneProduct ensembl:ENSG00000275379
HIST1H3E GeneProduct ensembl:ENSG00000274750
H2AFB3 GeneProduct ensembl:ENSG00000277745
H2AFJ GeneProduct ensembl:ENSG00000246705
H2AFV GeneProduct ensembl:ENSG00000105968
H2AFX GeneProduct ensembl:ENSG00000188486
H2AFY GeneProduct ensembl:ENSG00000113648
H2AFY2 GeneProduct ensembl:ENSG00000099284
H2AFZ GeneProduct ensembl:ENSG00000164032

References

  1. FBXL10 contributes to the development of diffuse large B-cell lymphoma by epigenetically enhancing ERK1/2 signaling pathway. Zhao X, Wang X, Li Q, Chen W, Zhang N, Kong Y, et al. Cell Death Dis. 2018 Jan 19;9(2):46. PubMed Europe PMC Scholia