ROBO4 and VEGF signaling crosstalk (WP3943)
Homo sapiens
This pathway is based on Figure 2 of "Robo4" (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637482/). The gene Robo4 plays a role in regulating vascular stability in mice. Robo4 inhibits the gene Notch1, which regulates tip cell formation, in order to create more tip cells. Robo4 also inhibits cell migration, decreasing vessel complexity. The combination of Slit2 and Robo4 inhibits the activation of Src by VEGF-165 and VEGFR2. This inhibition reduces vascular leakage of Evans Blue from retinal blood vessels. More experimentation is necessary to determine whether Robo4 will inhibit other members of the Src family. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3943 CPTAC Assay Portal]
Authors
Kristina Hanspers and Eric WeitzActivity
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Cited In
- ACE2 correlates with immune infiltrates in colon adenocarcinoma: Implication for COVID-19 (2021).
- Identification of candidate genes and pathways in retinopathy of prematurity by whole exome sequencing of preterm infants enriched in phenotypic extremes (2021).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
regulatory pathway Notch signaling pathway regulatory pathway Notch signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| ROBO4 | GeneProduct | ensembl:ENSG00000154133 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032125 |
| SLIT2 | GeneProduct | ensembl:ENSG00000145147 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031558 |
| KDR | GeneProduct | ensembl:ENSG00000128052 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000062960 |
| RAC1 | GeneProduct | ensembl:ENSG00000136238 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000001847 |
| VEGFA | GeneProduct | ensembl:ENSG00000112715 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000023951 |
| SRC | GeneProduct | ensembl:ENSG00000197122 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000027646 |
References
- Robo4: a guidance receptor that regulates angiogenesis. Weitzman M, Bayley EB, Naik UP. Cell Adh Migr. 2008;2(4):220–2. PubMed Europe PMC Scholia