LncRNA-like NMRK2 in translocation renal cell carcinoma (WP5519)

Homo sapiens

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NMRK2 mRNA acts as a long non-coding RNA (lncRNA) and enhancing mitochondrial respiration in NONO-TFE3 translocation renal cell carcinoma (tRCC). NMRK2 functions as a molecular scaffold to promote mitochondrial function in these cancer cells, independent of NAD+ kinase activity. NMRK2 upregulation contributes to tumor progression by improving cellular energy production through enhanced mitochondrial respiration. Targeting NMRK2 might help treat this aggressive RCC subtype.

Authors

Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

renal cell carcinoma cancer

Cell Type Ontology

neoplastic cell kidney cell

Participants
Query Drugst.One

Label Type Compact URI Comment
NAD+ Metabolite chebi:15846
ATP Metabolite chebi:15422
Fumarate Metabolite chebi:29806
Citrate Metabolite chebi:16947
MALAT1 GeneProduct ensembl:ENSG00000251562
NONO GeneProduct ensembl:ENSG00000147140
TFE3 GeneProduct ensembl:ENSG00000068323
NMRK2 GeneProduct ensembl:ENSG00000077009
SLC19A2 GeneProduct ensembl:ENSG00000117479
FH GeneProduct ensembl:ENSG00000091483
MDH2 GeneProduct ensembl:ENSG00000146701
CS GeneProduct ensembl:ENSG00000062485
HSPE1 GeneProduct ensembl:ENSG00000115541

References

  1. LncRNA like NMRK2 mRNA functions as a key molecular scaffold to enhance mitochondrial respiration of NONO-TFE3 rearranged renal cell carcinoma in an NAD+ kinase-independent manner. Chen Y, Lu Y, Yang L, Ma W, Dong Y, Zhou S, et al. J Exp Clin Cancer Res. 2023 Sep 28;42(1):252. PubMed Europe PMC Scholia