Mitochondrial fatty acid synthesis pathway (WP4317)

Homo sapiens

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Schematic presentation of the sequence of events. The indicated abbreviations follow the nomenclature used for the human enzymes and proteins. ACC, acetyl-CoA carboxylase; MCT, malonyl-CoA transferase; ACP, acyl-carrier protein; KAS, ketoacyl synthase; KAR, ketoacyl reductase; HTD2, hydroxyacyl-thioester reductase type 2; ETR, enoyl-thioester reductase. [J. Kastaniotis et al 2010]

Authors

Amadeo , Denise Slenter , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

citric acid cycle pathway classic metabolic pathway citric acid cycle pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
H Metabolite chebi:15378
Malonyl-CoA Metabolite hmdb:HMDB0001175
3-Ketoacyl-ACP Metabolite chebi:57347
Malonyl-ACP Metabolite kegg.compound:C01209
Octanoyl-ACP Metabolite chebi:7725
Acetyl-CoA Metabolite hmdb:HMDB0001206 The ChEBI ID with the correct charge is: 57288
ATP Metabolite hmdb:HMDB0000538 The ChEBI ID with the correct charge is: 30616
CO2 Metabolite hmdb:HMDB0001967
3-Hydroxyacyl-ACP Metabolite chebi:57318
Trans-2-enoyl-ACP Metabolite kegg.compound:C05748
Acetyl/Acyl-ACP Metabolite wikidata:Q59811305
NADP Metabolite hmdb:HMDB0000217
NADPH Metabolite hmdb:HMDB0000221 The ChEBI ID with the correct charge is: 57783
water Metabolite hmdb:HMDB0002111
MECR GeneProduct ensembl:ENSG00000116353
HSD17B12 GeneProduct ensembl:ENSG00000149084
HTD2 GeneProduct ensembl:ENSG00000255154
ACACA GeneProduct ensembl:ENSG00000278540
MCAT GeneProduct ensembl:ENSG00000100294
KAS GeneProduct ensembl:ENSG00000151093

References

  1. Mitochondrial fatty acid synthesis type II: more than just fatty acids. Hiltunen JK, Schonauer MS, Autio KJ, Mittelmeier TM, Kastaniotis AJ, Dieckmann CL. J Biol Chem. 2009 Apr 3;284(14):9011–5. PubMed Europe PMC Scholia
  2. Mitochondrial fatty acid synthesis and respiration. Hiltunen JK, Autio KJ, Schonauer MS, Kursu VAS, Dieckmann CL, Kastaniotis AJ. Biochim Biophys Acta. 2010;1797(6–7):1195–202. PubMed Europe PMC Scholia