Enterocyte cholesterol metabolism (WP5333)

Homo sapiens

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This pathway shows the cholesterol absorption and biosynthesis in the enterocyte.

Authors

Tom Pauly , Denise Slenter , and Susan Coort

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

cholesterol metabolic pathway cholesterol biosynthetic pathway cholesterol transport pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Esterase Metabolite hmdb:HMDB0302632
Phospholipase Metabolite hmdb:HMDB0302979
phospholipids Metabolite chebi:16247
cholesterol Metabolite chebi:16113
cholesterol esters Metabolite chebi:17002
triacylglycerols Metabolite chebi:17855
fatty acids Metabolite chebi:35366
cholesterol Metabolite chebi:16113
diacylglycerols Metabolite chebi:18035
monoacylglycerols Metabolite chebi:17408
DGL Metabolite chebi:15966
lysophospholipids Metabolite chebi:16961
cholesterol Metabolite chebi:16113
fatty acids Metabolite chebi:35366
lysophospholipids Metabolite chebi:16961
monoacylglycerols Metabolite chebi:17408
cholesterol esters Metabolite chebi:17002
phospholipids Metabolite chebi:16247
triacylglycerols Metabolite chebi:17855
cholesterol Metabolite chebi:16113
phospholipids Metabolite chebi:16247
Acetyl-CoA Metabolite cas:72-89-9
HMG-CoA Metabolite hmdb:HMDB0001375
Mevalonic acid Metabolite cas:150-97-0
Mevalonic acid 5-pyrophosphate Metabolite cas:1492-08-6
Mevalonic acid-5P Metabolite cas:73566-35-5
isopentenyl pyrophosphate Metabolite cas:358-71-4
Dimethylallyl pyrophosphate Metabolite cas:358-72-5
Geranyl-PP Metabolite cas:6699-20-3
lanosterol Metabolite chebi:16521
(S)-2,3-Epoxysqualene Metabolite chebi:15441
farnesyl pyrophosphate Metabolite cas:13058-04-3
Squalene Metabolite cas:111-02-4
zymosterol Metabolite chebi:18252
desmosterol Metabolite chebi:17737
Zymostenol Metabolite chebi:16608
24,25-dihydrolanosterol Metabolite chebi:28113
Lathosterol Metabolite cas:80-99-9
7-Dehydrocholesterol Metabolite cas:434-16-2
Cholesterol Metabolite cas:57-88-5
cholesterol Metabolite chebi:16113
cholesterol Metabolite chebi:16113
SLC27A4 GeneProduct ensembl:ENSG00000167114
MTTP GeneProduct ensembl:ENSG00000138823
APOA1 GeneProduct ensembl:ENSG00000118137
APOA1 GeneProduct ensembl:ENSG00000118137
DGAT1 GeneProduct ensembl:ENSG00000185000
APOA4 GeneProduct ensembl:ENSG00000110244
MGAT1 GeneProduct ensembl:ENSG00000131446
APOB GeneProduct ensembl:ENSG00000084674
ABCA1 GeneProduct ensembl:ENSG00000165029
ABCG8 GeneProduct ncbigene:64241
ABCG5 GeneProduct ncbigene:64240
NPC1L1 GeneProduct ensembl:ENSG00000015520
CD36 GeneProduct ensembl:ENSG00000135218
ACAT2 GeneProduct ensembl:ENSG00000120437
SAR1B GeneProduct ensembl:ENSG00000152700
HMGCS1 GeneProduct ncbigene:3157
HMGCR GeneProduct ncbigene:3156
MVD GeneProduct ncbigene:4597
PMVK GeneProduct ncbigene:10654
MVK GeneProduct ncbigene:4598
IDI1 GeneProduct ncbigene:3422
FDPS GeneProduct ncbigene:2224
SQLE GeneProduct ncbigene:6713
FDFT1 GeneProduct ncbigene:2222
LSS GeneProduct ncbigene:4047
FDPS GeneProduct ncbigene:2224
DHCR24 GeneProduct ensembl:ENSG00000116133
EBP GeneProduct ensembl:ENSG00000147155
DHCR7 GeneProduct ncbigene:1717
SC5DL GeneProduct ncbigene:6309
EBP GeneProduct ensembl:ENSG00000147155
DHCR7 GeneProduct ncbigene:1717
DHCR24 GeneProduct ensembl:ENSG00000116133
DHCR24 GeneProduct ensembl:ENSG00000116133
SC5DL GeneProduct ncbigene:6309
DHCR24 GeneProduct ensembl:ENSG00000116133
DHCR24 GeneProduct ensembl:ENSG00000116133
DHCR24 GeneProduct ensembl:ENSG00000116133
CYP51A1 GeneProduct ensembl:ENSG00000001630
CYP51A1 GeneProduct ensembl:ENSG00000001630
HSD17B7 GeneProduct ensembl:ENSG00000132196
NSDHL GeneProduct ncbigene:50814 NAD(P) dependent steroid dehydrogenase-like
SC4MOL GeneProduct ncbigene:6307
HSD17B7 GeneProduct ensembl:ENSG00000132196
NSDHL GeneProduct ncbigene:50814 NAD(P) dependent steroid dehydrogenase-like
SC4MOL GeneProduct ncbigene:6307
DHCR24 GeneProduct ensembl:ENSG00000116133
LBR GeneProduct ensembl:ENSG00000143815
TM7SF2 GeneProduct ensembl:ENSG00000149809
LBR GeneProduct ensembl:ENSG00000143815
TM7SF2 GeneProduct ensembl:ENSG00000149809
LDLR GeneProduct ensembl:ENSG00000130164
FABP2 GeneProduct ensembl:ENSG00000145384
Triacylglycerol lipase Protein uniprot:A0A087WX88

References

  1. Cholesterol esterase activity of human intestinal mucosa. Ponz de Leon M, Carubbi F, Di Donato P, Carulli N. Dig Dis Sci. 1985 Nov;30(11):1053–64. PubMed Europe PMC Scholia
  2. Phospholipases: structural and functional motifs for working at an interface. Roberts MF. FASEB J. 1996 Aug;10(10):1159–72. PubMed Europe PMC Scholia
  3. Mechanisms by Which LRP1 (Low-Density Lipoprotein Receptor-Related Protein-1) Maintains Arterial Integrity. Gonias SL. Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2548–9. PubMed Europe PMC Scholia
  4. The TICE Pathway: Mechanisms and Lipid-Lowering Therapies. Grefhorst A, Verkade HJ, Groen AK. Methodist Debakey Cardiovasc J. 2019;15(1):70–6. PubMed Europe PMC Scholia
  5. Rare dyslipidaemias, from phenotype to genotype to management: a European Atherosclerosis Society task force consensus statement. Hegele RA, Borén J, Ginsberg HN, Arca M, Averna M, Binder CJ, et al. Lancet Diabetes Endocrinol. 2020 Jan;8(1):50–67. PubMed Europe PMC Scholia
  6. Regulation of intestinal lipid metabolism: current concepts and relevance to disease. Ko CW, Qu J, Black DD, Tso P. Nat Rev Gastroenterol Hepatol. 2020 Mar;17(3):169–83. PubMed Europe PMC Scholia