Hippo signaling regulation (WP4540)

Homo sapiens

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Hippo signaling and the activation of YAP1/TAZ transcription is regulated by many other pathways (green labels) and factors. For example, the activation of SMAD and Beta catenin/TCF/LEF via TGF-beta signaling and WNT signaling pathways, respectively, enhanced the transcription of YAP1/TAZ target genes. This enhanced activity induces more aggressive phenotypes of malignant mesothelioma cells such as cell proliferation, invasion, and epithelial–mesenchymal transition (EMT). This pathway was created based on figure 2 from Sekido et al. Phosphorylation sites were added based on information from PhosphoSitePlus, www.phosphosite.org.

Authors

Alex Pico , Eric Weitz , Friederike Ehrhart , and Kristina Hanspers

Activity

last edited pathway curation

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Cited In

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Organisms

Homo sapiens

Communities

Diseases Rare Diseases

Annotations

Disease Ontology

malignant mesothelioma

Pathway Ontology

disease pathway signaling pathway Hippo signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
PRKAA1 GeneProduct ncbigene:5562 AMPK
PRKAA2 GeneProduct ncbigene:5563 AMPK
PRKAB1 GeneProduct ncbigene:5564 AMPK
PRKAB2 GeneProduct ncbigene:5565 AMPK
PRKAG1 GeneProduct ncbigene:5571 AMPK
PRKAG2 GeneProduct ncbigene:51422 AMPK
PRKAG3 GeneProduct ncbigene:53632 AMPK
CDH1 GeneProduct ncbigene:999 Cadherin
CDH10 GeneProduct ncbigene:1008 Cadherin
CDH11 GeneProduct ncbigene:1009 Cadherin
CDH12 GeneProduct ncbigene:1010 Cadherin
CDH13 GeneProduct ncbigene:1012 Cadherin
CDH15 GeneProduct ncbigene:1013 Cadherin
CDH16 GeneProduct ncbigene:1014 Cadherin
CDH17 GeneProduct ncbigene:1015 Cadherin
CDH18 GeneProduct ncbigene:1016 Cadherin
CDH19 GeneProduct ncbigene:28513 Cadherin
CDH2 GeneProduct ncbigene:1000 Cadherin
CDH20 GeneProduct ncbigene:28316 Cadherin
CDH22 GeneProduct ncbigene:64405 Cadherin
CDH24 GeneProduct ncbigene:64403 Cadherin
CDH3 GeneProduct ncbigene:1001 Cadherin
CDH4 GeneProduct ncbigene:1002 Cadherin
CDH5 GeneProduct ncbigene:1003 Cadherin
CDH6 GeneProduct ncbigene:1004 Cadherin
CDH7 GeneProduct ncbigene:1005 Cadherin
CDH8 GeneProduct ncbigene:1006 Cadherin
CDH9 GeneProduct ncbigene:1007 Cadherin
GNA11 GeneProduct ncbigene:2767 Ga/1
GNAI2 GeneProduct ncbigene:2771 Ga/1
GNAI3 GeneProduct ncbigene:2773 Ga/1
GNAL GeneProduct ncbigene:2774 Ga/1
GNAQ GeneProduct ncbigene:2776 Ga/1
GNAS GeneProduct ncbigene:2778 Ga/1
PRKACA GeneProduct ncbigene:5566 PKA
PRKACB GeneProduct ncbigene:5567 PKA
PRKACG GeneProduct ncbigene:5568 PKA
PRKAR1A GeneProduct ncbigene:5573 PKA
PRKAR1B GeneProduct ncbigene:5575 PKA
PRKAR2A GeneProduct ncbigene:5576 PKA
PRKAR2B GeneProduct ncbigene:5577 PKA
PRKCA GeneProduct ncbigene:5578 PKC
PRKCB GeneProduct ncbigene:5579 PKC
PRKCD GeneProduct ncbigene:5580 PKC
PRKCE GeneProduct ncbigene:5581 PKC
PRKCG GeneProduct ncbigene:5582 PKC
PRKCH GeneProduct ncbigene:5583 PKC
PRKCI GeneProduct ncbigene:5584 PKC
PRKCQ GeneProduct ncbigene:5588 PKC
PRKCZ GeneProduct ncbigene:5590 PKC
PRKD3 GeneProduct ncbigene:23683 PKC
PLCB1 GeneProduct ncbigene:23236 PLCB
PLCB2 GeneProduct ncbigene:5330 PLCB
PLCB3 GeneProduct ncbigene:5331 PLCB
PLCB4 GeneProduct ncbigene:5332 PLCB
SMAD3 GeneProduct ncbigene:4088 SMAD
CDC42 GeneProduct ncbigene:998
SMAD2 GeneProduct ncbigene:4087 SMAD
MTOR GeneProduct ncbigene:2475 mTOR
LATS2 GeneProduct ncbigene:26524 LATS1/2
STK3 GeneProduct ncbigene:6788 MST1/2
LATS1 GeneProduct ncbigene:9113 LATS1/2
NF2 GeneProduct ncbigene:4771 Nf2
STK4 GeneProduct ncbigene:4485 MST1/2
TEAD1 GeneProduct ensembl:ENSG00000187079
TEAD2 GeneProduct ensembl:ENSG00000074219
TEAD3 GeneProduct ensembl:ENSG00000007866
TEAD4 GeneProduct ensembl:ENSG00000197905
FGFR2 GeneProduct ensembl:ENSG00000066468 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14183
KDR GeneProduct ensembl:ENSG00000128052 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16542
INSR GeneProduct ensembl:ENSG00000171105 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16337
FGFR3 GeneProduct ensembl:ENSG00000068078 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14184
IGF1R GeneProduct ensembl:ENSG00000140443 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16001
KIT GeneProduct ensembl:ENSG00000157404 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16590
FGFR1 GeneProduct ensembl:ENSG00000077782 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14182
EPHA2 GeneProduct ensembl:ENSG00000142627 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13836
EGFR GeneProduct ensembl:ENSG00000146648 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13649
CSF1R GeneProduct ensembl:ENSG00000182578 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12978
FGFR4 GeneProduct ensembl:ENSG00000160867 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14186
FLT1 GeneProduct ensembl:ENSG00000102755 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14254
FLT4 GeneProduct ensembl:ENSG00000037280 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257
NGFR GeneProduct ensembl:ENSG00000064300 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18053
MET GeneProduct ensembl:ENSG00000105976 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17295
PDGFRA GeneProduct ensembl:ENSG00000134853 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18595
PDGFRB GeneProduct ensembl:ENSG00000113721 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18596
TEK GeneProduct ensembl:ENSG00000120156 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
FLT3 GeneProduct ensembl:ENSG00000122025 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257
NTRK1 GeneProduct ensembl:ENSG00000198400 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
NTRK2 GeneProduct ensembl:ENSG00000148053 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
RHOA GeneProduct ncbigene:387
RAC1 GeneProduct ncbigene:5879
LEF1 GeneProduct ensembl:ENSG00000138795
TCF7L1 GeneProduct ensembl:ENSG00000152284
TCF7L2 GeneProduct ensembl:ENSG00000148737
TCF7 GeneProduct ensembl:ENSG00000081059
CTNNB1 GeneProduct ncbigene:1499
WWTR1 GeneProduct ncbigene:25937
YAP1 GeneProduct ncbigene:10413

References

  1. Targeting the Hippo Pathway Is a New Potential Therapeutic Modality for Malignant Mesothelioma. Sekido Y. Cancers (Basel). 2018 Mar 22;10(4):90. PubMed Europe PMC Scholia