Effect of dasatinib on the BCR-ABL signaling pathway (WP5493)

Homo sapiens

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Effect of dasatinib on the BCR-ABL signaling pathway, showing phosphorylation sites that were found to be suppressed by Dasatinib are shown (Pan et al). Key signaling events in the three major MAPK cascades were suppressed, including the activation loop phosphorylation sites of p38α/β (MAPK11) and ERK1/2 (MAPK1/MAPK3). Based on fig 6 from https://pmc.ncbi.nlm.nih.gov/articles/PMC2816010/Phosphorylation site information is based on the left-side panel in the figure; not all sites could be verified in independent sources (e.g. PhosphositePlus).

Authors

Kristina Hanspers

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

altered growth factor signaling pathway leukemia pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
SPAG1 GeneProduct ncbigene:6674
BCR GeneProduct ncbigene:613
BCL9 GeneProduct ncbigene:607
PIK3R1 GeneProduct ncbigene:5295
SOS1 GeneProduct ncbigene:6654
MAPK3 GeneProduct ncbigene:5595
ABL1 GeneProduct ncbigene:25
CRKL GeneProduct ncbigene:1399
PXN GeneProduct ncbigene:5829
GRB2 GeneProduct ncbigene:2885
PIK3CA GeneProduct ncbigene:5290
VAV1 GeneProduct ncbigene:7409
ARAF GeneProduct ncbigene:369 OCR lexicon match: RAF
BRAF GeneProduct ncbigene:673 OCR lexicon match: RAF
RAF1 GeneProduct ncbigene:5894 OCR lexicon match: RAF
KRAS GeneProduct ncbigene:3845 OCR lexicon match: RAS
HRAS GeneProduct ncbigene:3265 OCR lexicon match: RAS
NRAS GeneProduct ncbigene:4893 OCR lexicon match: RAS
SHC1 GeneProduct ncbigene:6464 OCR lexicon match: SHC
SHC2 GeneProduct ncbigene:25759 OCR lexicon match: SHC
SHC3 GeneProduct ncbigene:53358 OCR lexicon match: SHC
SHC4 GeneProduct ncbigene:399694 OCR lexicon match: SHC
GAB2 GeneProduct ncbigene:9846 OCR lexicon match: GAB2
BCL2 GeneProduct ncbigene:596 OCR lexicon match: BCL2
MAP3K2 GeneProduct ncbigene:10746 OCR lexicon match: MEKK2
AKT1 GeneProduct ncbigene:207 OCR lexicon match: AKT
AKT2 GeneProduct ncbigene:208 OCR lexicon match: AKT
AKT3 GeneProduct ncbigene:10000 OCR lexicon match: AKT
RPS6KA1 GeneProduct ncbigene:6195 OCR lexicon match: RSK
EIF4B GeneProduct ncbigene:1975 OCR lexicon match: EIF4B
MAPK11 GeneProduct ncbigene:5600
HSPB1 GeneProduct ncbigene:3315 OCR lexicon match: HSP27
HSPB2 GeneProduct ncbigene:3316 OCR lexicon match: HSP27
ATF2 GeneProduct ncbigene:1386 OCR lexicon match: ATF2
CBL GeneProduct ncbigene:867 OCR lexicon match: CBL
CRK GeneProduct ncbigene:1398 OCR lexicon match: CRK
PTK2 GeneProduct ncbigene:5747 OCR lexicon match: FAK
BCAR1 GeneProduct ncbigene:9564 OCR lexicon match: CAS
MEF2C GeneProduct ncbigene:4208 OCR lexicon match: MEF2C
SRC GeneProduct ncbigene:6714 OCR lexicon match: SRC
BCLAF1 GeneProduct ncbigene:9774 OCR lexicon match: BCLAF1
MAPK1 GeneProduct ncbigene:5594
INPP5D GeneProduct ncbigene:3635
DOK1 GeneProduct ncbigene:1796
MAPK14 GeneProduct ncbigene:1432

References

  1. Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics. Pan C, Olsen JV, Daub H, Mann M. Mol Cell Proteomics. 2009 Dec;8(12):2796–808. PubMed Europe PMC Scholia