TROP2 regulatory signaling (WP5300)

Homo sapiens

Authors

Rex D A B , Eric Weitz , and Kristina Hanspers

Activity

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway cancer pathway

Disease Ontology

stomach cancer

References

1. Tumor-associated calcium signal transducer 2 is required for the proper subcellular localization of claudin 1 and 7: implications in the pathogenesis of gelatinous drop-like corneal dystrophy. Nakatsukasa M, Kawasaki S, Yamasaki K, Fukuoka H, Matsuda A, Tsujikawa M, et al. Am J Pathol. 2010 Sep;177(3):1344–55. PubMed Europe PMC Scholia
2. Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway. Cubas R, Zhang S, Li M, Chen C, Yao Q. Mol Cancer. 2010 Sep 21;9:253. PubMed Europe PMC Scholia
3. Trop-2 inhibits prostate cancer cell adhesion to fibronectin through the β1 integrin-RACK1 axis. Trerotola M, Li J, Alberti S, Languino LR. J Cell Physiol. 2012 Nov;227(11):3670–7. PubMed Europe PMC Scholia
4. TROP2 is epigenetically inactivated and modulates IGF-1R signalling in lung adenocarcinoma. Lin JC, Wu YY, Wu JY, Lin TC, Wu CT, Chang YL, et al. EMBO Mol Med. 2012 Jun;4(6):472–85. PubMed Europe PMC Scholia
5. The Trop-2 signalling network in cancer growth. Guerra E, Trerotola M, Aloisi AL, Tripaldi R, Vacca G, La Sorda R, et al. Oncogene. 2013 Mar 21;32(12):1594–600. PubMed Europe PMC Scholia
6. Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling. Stoyanova T, Goldstein AS, Cai H, Drake JM, Huang J, Witte ON. Genes Dev. 2012 Oct 15;26(20):2271–85. PubMed Europe PMC Scholia
7. Trop-2 promotes prostate cancer metastasis by modulating β(1) integrin functions. Trerotola M, Jernigan DL, Liu Q, Siddiqui J, Fatatis A, Languino LR. Cancer Res. 2013 May 15;73(10):3155–67. PubMed Europe PMC Scholia
8. Trop2 regulates the proliferation and differentiation of murine compact-bone derived MSCs. Yang J, Zhu Z, Wang H, Li F, Du X, Ma RZ. Int J Oncol. 2013 Sep;43(3):859–67. PubMed Europe PMC Scholia
9. Overexpression of TROP2 predicts poor prognosis of patients with cervical cancer and promotes the proliferation and invasion of cervical cancer cells by regulating ERK signaling pathway. Liu T, Liu Y, Bao X, Tian J, Liu Y, Yang X. PLoS One. 2013 Sep 27;8(9):e75864. PubMed Europe PMC Scholia
10. Trop2 inhibition suppresses the proliferation and invasion of laryngeal carcinoma cells via the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway. Wang XD, Wang Q, Chen XL, Huang JF, Yin Y, Da P, et al. Mol Med Rep. 2015 Jul;12(1):865–70. PubMed Europe PMC Scholia
11. Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts. Trerotola M, Ganguly KK, Fazli L, Fedele C, Lu H, Dutta A, et al. Oncotarget. 2015 Jun 10;6(16):14318–28. PubMed Europe PMC Scholia
12. Trop-2 Induces Tumor Growth Through AKT and Determines Sensitivity to AKT Inhibitors. Guerra E, Trerotola M, Tripaldi R, Aloisi AL, Simeone P, Sacchetti A, et al. Clin Cancer Res. 2016 Aug 15;22(16):4197–205. PubMed Europe PMC Scholia
13. v-Src Oncogene Induces Trop2 Proteolytic Activation via Cyclin D1. Ju X, Jiao X, Ertel A, Casimiro MC, Di Sante G, Deng S, et al. Cancer Res. 2016 Nov 15;76(22):6723–34. PubMed Europe PMC Scholia
14. Tumor-associated calcium signal transducer 2 regulates neovascularization of non-small-cell lung cancer via activating ERK1/2 signaling pathway. Guo X, Zhu X, Zhao L, Li X, Cheng D, Feng K. Tumour Biol. 2017 Mar;39(3):1010428317694324. PubMed Europe PMC Scholia
15. TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT. Li X, Teng S, Zhang Y, Zhang W, Zhang X, Xu K, et al. Oncotarget. 2017 Jul 18;8(29):47052–63. PubMed Europe PMC Scholia
16. Trop2 enhances invasion of thyroid cancer by inducing MMP2 through ERK and JNK pathways. Guan H, Guo Z, Liang W, Li H, Wei G, Xu L, et al. BMC Cancer. 2017 Jul 14;17(1):486. PubMed Europe PMC Scholia
17. Overexpression of TROP2 promotes proliferation and invasion of ovarian cancer cells. Wu B, Yu C, Zhou B, Huang T, Gao L, Liu T, et al. Exp Ther Med. 2017 Sep;14(3):1947–52. PubMed Europe PMC Scholia
18. TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling. Gu QZ, Nijiati A, Gao X, Tao KL, Li CD, Fan XP, et al. Mol Med Rep. 2018 Aug;18(2):1782–8. PubMed Europe PMC Scholia
19. TROP-2 exhibits tumor suppressive functions in cervical cancer by dual inhibition of IGF-1R and ALK signaling. Sin STK, Li Y, Liu M, Ma S, Guan XY. Gynecol Oncol. 2019 Jan;152(1):185–93. PubMed Europe PMC Scholia
20. TROP2 promotes the proliferation and metastasis of glioblastoma cells by activating the JAK2/STAT3 signaling pathway. Hou J, Lv A, Deng Q, Zhang G, Hu X, Cui H. Oncol Rep. 2019 Feb;41(2):753–64. PubMed Europe PMC Scholia
21. The role and molecular mechanism of Trop2 induced epithelial-mesenchymal transition through mediated β-catenin in gastric cancer. Zhao W, Jia L, Kuai X, Tang Q, Huang X, Yang T, et al. Cancer Med. 2019 Mar;8(3):1135–47. PubMed Europe PMC Scholia
22. Trophoblast cell surface antigen 2 (Trop-2) phosphorylation by protein kinase C α/δ (PKCα/δ) enhances cell motility. Mori Y, Akita K, Ojima K, Iwamoto S, Yamashita T, Morii E, et al. J Biol Chem. 2019 Jul 26;294(30):11513–24. PubMed Europe PMC Scholia
23. TROP2 increases growth and metastasis of human oral squamous cell carcinoma through activation of the PI3K/Akt signaling pathway. Tang G, Tang Q, Jia L, Chen Y, Lin L, Kuai X, et al. Int J Mol Med. 2019 Dec;44(6):2161–70. PubMed Europe PMC Scholia
24. Trop2 is a driver of metastatic prostate cancer with neuroendocrine phenotype via PARP1. Hsu EC, Rice MA, Bermudez A, Marques FJG, Aslan M, Liu S, et al. Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):2032–42. PubMed Europe PMC Scholia
25. Trop2 Promotes Multidrug Resistance by Regulating Notch1 Signaling Pathway in Gastric Cancer Cells. Kuai X, Jia L, Yang T, Huang X, Zhao W, Zhang M, et al. Med Sci Monit. 2020 Jan 22;26:e919566. PubMed Europe PMC Scholia
26. Proteolytic cleavage of Trop2 at Arg87 is mediated by matriptase and regulated by Val194. Kamble PR, Rane S, Breed AA, Joseph S, Mahale SD, Pathak BR. FEBS Lett. 2020 Oct;594(19):3156–69. PubMed Europe PMC Scholia
27. Trop2 inhibition of P16 expression and the cell cycle promotes intracellular calcium release in OSCC. Jia L, Wang T, Ding G, Kuai X, Wang X, Wang B, et al. Int J Biol Macromol. 2020 Dec 1;164:2409–17. PubMed Europe PMC Scholia
28. Trop-2 cleavage by ADAM10 is an activator switch for cancer growth and metastasis. Trerotola M, Guerra E, Ali Z, Aloisi AL, Ceci M, Simeone P, et al. Neoplasia. 2021 Apr;23(4):415–28. PubMed Europe PMC Scholia
29. Trop-2 induces ADAM10-mediated cleavage of E-cadherin and drives EMT-less metastasis in colon cancer. Guerra E, Trerotola M, Relli V, Lattanzio R, Tripaldi R, Vacca G, et al. Neoplasia. 2021 Sep;23(9):898–911. PubMed Europe PMC Scholia
30. Trop2 binding IGF2R induces gefitinib resistance in NSCLC by remodeling the tumor microenvironment. Sun X, Jia L, Wang T, Zhang Y, Zhao W, Wang X, et al. J Cancer. 2021 Jul 3;12(17):5310–9. PubMed Europe PMC Scholia
31. Trop2 Forms a Stable Dimer with Significant Structural Differences within the Membrane-Distal Region as Compared to EpCAM. Pavšič M. Int J Mol Sci. 2021 Sep 30;22(19):10640. PubMed Europe PMC Scholia