Lacto series sphingolipid metabolism (WP5303)

Homo sapiens

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Lacto series glycosphingolipid biosynthesis. Lactosylceramides (abbreviated as LacCer) are a class of glycosphingolipids connecting a ceramide lipid to a sugar group. The exact chemical formula and molecular weight in this class of lipids varies depending on the connected fatty-acid. Many of these structures are related to cancer development or antigens. Source: https://en.wikipedia.org/wiki/Lactosylceramide

For a description of pathway objects, see the WikiPathways Legend.

Authors

Matthew Conroy , Alex Pico , Lars Willighagen , Eric Weitz , and Denise Slenter

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology

ganglioside metabolic pathway lacto-series glycosphingolipid metabolic pathway lipid metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Lewis A Metabolite lipidmaps:LMSP0504AC00
Lewis B Metabolite lipidmaps:LMSP0504AI00
Lc3Cer Metabolite lipidmaps:LMSP0504AA00
Type I H antigen Metabolite lipidmaps:LMSP0504AD00
Type IA antigen Metabolite lipidmaps:LMSP0504AF00
Sialyl-lactotetraosylceramide Metabolite lipidmaps:LMSP0601DK00
Sialyl Lewis A Metabolite lipidmaps:LMSP0601DL00
Type IB antigen Metabolite lipidmaps:LMSP0504AE00
A Lewis B Metabolite lipidmaps:LMSP0504AH00
Lc4Cer/LM1 Metabolite lipidmaps:LMSP0504AB00 ChEBI 17292, Smap 8
LacCer Metabolite lipidmaps:LMSP0501AB00
B3GALT1 Protein uniprot:Q9Y5Z6
FUT3 Protein uniprot:P21217
B3GALT2 Protein uniprot:O43825
FUT2 Protein uniprot:Q10981
FUT1 Protein uniprot:P19526
B3GNT5 Protein uniprot:Q9BYG0

References

  1. Handbook of Glycosyltransferases and Related Genes [Internet]. Taniguchi N, Honke K, Fukuda M, Clausen H, Furukawa K, Hart GW, et al., editors. Springer Japan; 2002. Available from: http://dx.doi.org/10.1007/978-4-431-67877-9 DOI Scholia
  2. Substrate specificity of beta 1,4-N-acetylgalactosaminyltransferase in vitro and in cDNA-transfected cells. GM2/GD2 synthase efficiently generates asialo-GM2 in certain cells. Yamashiro S, Haraguchi M, Furukawa K, Takamiya K, Yamamoto A, Nagata Y, et al. J Biol Chem. 1995 Mar 17;270(11):6149–55. PubMed Europe PMC Scholia
  3. SphinGOMAP--a web-based biosynthetic pathway map of sphingolipids and glycosphingolipids. Merril AH Jr. Glycobiology. 2005 Jun;15(6):15G. PubMed Europe PMC Scholia
  4. Structure and function of glycosphingolipids and sphingolipids: recollections and future trends. Hakomori S itiroh. Biochim Biophys Acta. 2008 Mar;1780(3):325–46. PubMed Europe PMC Scholia