Leptin and adiponectin (WP3934)

Homo sapiens

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Proposed mechanism by which leptin and adiponectin stimulate fatty acid oxidation. Adapted from fig 1 in [http://www.ncbi.nlm.nih.gov/pubmed/16497175 Dyck et al.]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3934 CPTAC Assay Portal]

Authors

Kristina Hanspers

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

glucose metabolism disease

Pathway Ontology

leptin system pathway adiponectin signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Fatty acid Metabolite chebi:35366
Acetyl-CoA Metabolite chebi:15351
Malonyl-CoA Metabolite chebi:15531
ADIPOR1 GeneProduct ensembl:ENSG00000159346 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72674
PRKAA1 GeneProduct ensembl:ENSG00000132356 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:105787
PRKAB1 GeneProduct ensembl:ENSG00000111725 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19079
LEP GeneProduct ensembl:ENSG00000174697 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16846
ADIPOR2 GeneProduct ensembl:ENSG00000006831 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68465
ACACA GeneProduct ensembl:ENSG00000278540 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:107476
PRKAG1 GeneProduct ensembl:ENSG00000181929 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19082
LEPR GeneProduct ensembl:ENSG00000116678 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16847
CPT1A GeneProduct ensembl:ENSG00000110090 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12894
ADIPOQ GeneProduct ensembl:ENSG00000181092 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11450

References

  1. The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity. Dyck DJ, Heigenhauser GJF, Bruce CR. Acta Physiol (Oxf). 2006 Jan;186(1):5–16. PubMed Europe PMC Scholia