IDO metabolic pathway (WP5414)

Homo sapiens

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Overview of the IDO metabolic pathway. Approximately 95% of L-tryptophan (Trp) is catabolized into kynurenine (Kyn) through three rate-limiting enzymes: tryptophan 2,3-dioxygenase (TDO) in the liver and indoleamine 2, 3-dioxygenase 1/2 (IDO1/2) in peripheral tissues. Kyn is converted to 3-hydroxykynurenine (3-HK) by kynurenine 3-monooxygenase (KMO), to anthranilic acid (AA) by kynureninase (KYNase), or to kynurenic acid (KYNA) by kynurenine aminotransferase (KAT). Next, catalyzed by KYNase, 3-HK is converted to 3-hydroxyanthranilic acid (3-HAA), which is further converted to quinolinic acid (QA), picolinic acid, nicotinamide adenine dinucleotide (NAD+), and other molecules. Starting point: https://pfocr.wikipathways.org/figures/PMC6090955__13045_2018_644_Fig1_HTML.html

Authors

Martina Summer-Kutmon and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

classic metabolic pathway tryptophan metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
3-Hydroxykynurenine Metabolite chebi:1547
Kynurenic acid Metabolite chebi:18344
Picolinic acid Metabolite chebi:28747
L-Tryptophan Metabolite chebi:16828
3-Hydroxyanthranilic acid Metabolite chebi:15793
Quinolinic acid Metabolite chebi:16675
Neopterin Metabolite cas:2009-64-5
Anthranilic acid Metabolite chebi:30754
Kynurenine Metabolite chebi:57959
NAD+ Metabolite chebi:13389
IFNG Protein uniprot:P01579
KYNU Protein uniprot:Q16719
KAT1 Protein uniprot:Q16773
KMO Protein uniprot:O15229
IDO1 Protein uniprot:P14902
IDO2 Protein uniprot:Q6ZQW0
T23O Protein uniprot:P48775
KAT3 Protein uniprot:Q6YP21
AADAT Protein uniprot:Q8N5Z0
AATM Protein uniprot:P00505
TNFA Protein uniprot:P01375

References

  1. Targeting the IDO1 pathway in cancer: from bench to bedside. Liu M, Wang X, Wang L, Ma X, Gong Z, Zhang S, et al. J Hematol Oncol. 2018 Aug 2;11(1):100. PubMed Europe PMC Scholia
  2. Systemic Perturbations in Amine and Kynurenine Metabolism Associated with Acute SARS-CoV-2 Infection and Inflammatory Cytokine Responses. Lawler NG, Gray N, Kimhofer T, Boughton B, Gay M, Yang R, et al. J Proteome Res. 2021 May 7;20(5):2796–811. PubMed Europe PMC Scholia