Acetaminophen in analgesia and antipyresis (WP5444)

Homo sapiens

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Plausible mechanisms of action for the pain-relieving and fever-reducing effects of acetaminophen, also known as paracetemol, Tylenol, or panadol. This is based on Figure 2 of https://doi.org/10.1111/1440-1681.13392.

Authors

Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

serotonergic neuron neuron GABAergic neuron

Pathway Ontology

drug pathway paracetamol drug pathway paracetamol response pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
GABA Metabolite chebi:16865
Acetaminophen Metabolite chebi:46195
AM404 Metabolite wikidata:Q4652517
CB1 Metabolite chebi:73416
1,4-benzoquinone Metabolite chebi:16509 'p-BQ, benzoquinone' per source (DOI: 10.1111/1440-1681.13392)
NAPQI Metabolite chebi:29132 'p-BQ, benzoquinone' per source (DOI: 10.1111/1440-1681.13392)
HTR1A GeneProduct ensembl:ENSG00000178394 'HT-5' per main source; specified as '5-HT1A' (officially HTR1A) in PMID 15777873 cited in main source.
PTGS1 GeneProduct ensembl:ENSG00000095303 'COX1' per source
PTGS2 GeneProduct ensembl:ENSG00000073756 'COX2' per source
FAAH GeneProduct ensembl:ENSG00000117480
TRPV1 GeneProduct ensembl:ENSG00000196689
CACNA1H GeneProduct ensembl:ENSG00000196557 'T-type cav 3.2' per source (DOI: 10.1111/1440-1681.13392)
TRPA1 GeneProduct ensembl:ENSG00000104321
KCNQ2 GeneProduct ensembl:ENSG00000075043 'Kv7.2' per source (DOI: 10.1111/1440-1681.13392)
KCNQ3 GeneProduct ensembl:ENSG00000184156 'Kv7.3' per source (DOI: 10.1111/1440-1681.13392)

References

  1. Spinal 5-HT1A receptors differentially influence nociceptive processing according to the nature of the noxious stimulus in rats: effect of WAY-100635 on the antinociceptive activities of paracetamol, venlafaxine and 5-HT. Bonnefont J, Chapuy E, Clottes E, Alloui A, Eschalier A. Pain. 2005 Apr;114(3):482–90. PubMed Europe PMC Scholia
  2. Paracetamol - An old drug with new mechanisms of action. Przybyła GW, Szychowski KA, Gmiński J. Clin Exp Pharmacol Physiol. 2021 Jan;48(1):3–19. PubMed Europe PMC Scholia