Direct reversal repair (WP4931)

Homo sapiens

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Direct reversal repair is a mechanism of repair where the damaged area or lesion is repaired directly by specialized proteins. It does not involve breakage of the phosphodiester backbone and doesn't require a reference template unlike the other single-strand repair mechanism. Methylation of guanine bases is directly reversed by the protein methyl guanine methyl transferase (MGMT). This is an expensive process because each MGMT molecule can be used only once. Methylation of the bases cytosine and adenine is repaired by ALKBH2 and ALKBH3. This pathway is based on information from [http://repairtoire.genesilico.pl/Pathway/4/ REPAIRtoire] and [https://en.wikipedia.org/wiki/Base_excision_repair Wikipedia].

Authors

Kristina Hanspers and Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

CPTAC

Annotations

Pathway Ontology

DNA repair pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
ALKBH2 GeneProduct ensembl:ENSG00000189046
ALKBH3 GeneProduct ensembl:ENSG00000166199
MGMT GeneProduct ensembl:ENSG00000170430

References