Markers of kidney cell lineage (WP5236)

Homo sapiens

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This pathway contains a timely and spatially differentiated map of cell markers for kidney development. These are relevant to study the congenital anomalies of kidney and urinary tract (CAKUT) disorders.

Authors

Friederike Ehrhart , Martina Summer-Kutmon , Alex Pico , Lars Willighagen , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

kidney interstitial fibroblast glomerular visceral epithelial cell progenitor cell parietal epithelial cell kidney cell mesangial cell pericyte cell

Pathway Ontology

regulatory pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
RSPO1 GeneProduct ensembl:ENSG00000169218
RSPO3 GeneProduct ensembl:ENSG00000146374
REN GeneProduct ensembl:ENSG00000143839 renin
PECAM1 GeneProduct ensembl:ENSG00000261371 CD31
FGF8 GeneProduct ensembl:ENSG00000107831
KIT GeneProduct ensembl:ENSG00000157404 c-Kit
NPHS2 GeneProduct ensembl:ENSG00000116218
KCTD1 GeneProduct ensembl:ENSG00000134504
FOXD1 GeneProduct ensembl:ENSG00000251493
KDR GeneProduct ensembl:ENSG00000128052 FLK1
TNC GeneProduct ensembl:ENSG00000041982
NOTCH1 GeneProduct ensembl:ENSG00000148400
HNF1A GeneProduct ensembl:ENSG00000135100
EYA1 GeneProduct ensembl:ENSG00000104313
BMP7 GeneProduct ensembl:ENSG00000101144
PDGFRB GeneProduct ensembl:ENSG00000113721
AXIN2 GeneProduct ensembl:ENSG00000168646
PBX1 GeneProduct ensembl:ENSG00000185630
ACTA2 GeneProduct ensembl:ENSG00000107796 α-SMA
TBX18 GeneProduct ensembl:ENSG00000112837
OSR1 GeneProduct ensembl:ENSG00000143867
HNF4A GeneProduct ensembl:ENSG00000101076
EMX2 GeneProduct ensembl:ENSG00000170370
CITED1 GeneProduct ensembl:ENSG00000125931
JAG1 GeneProduct ensembl:ENSG00000101384
SMAD1 GeneProduct ensembl:ENSG00000170365
AP2B1 GeneProduct ensembl:ENSG00000006125
SALL1 GeneProduct ensembl:ENSG00000103449
WNT4 GeneProduct ensembl:ENSG00000162552
EPO GeneProduct ensembl:ENSG00000130427 Erythropoietin
TSHZ3 GeneProduct ensembl:ENSG00000121297
GDNF GeneProduct ensembl:ENSG00000168621
HNF1B GeneProduct ensembl:ENSG00000275410
WT1 GeneProduct ensembl:ENSG00000184937
EGLN1 GeneProduct ensembl:ENSG00000135766 PHD2
SFRP1 GeneProduct ensembl:ENSG00000104332
TCF21 GeneProduct ensembl:ENSG00000118526 POD1
DACT1 GeneProduct ensembl:ENSG00000165617
DES GeneProduct ensembl:ENSG00000175084 desmin
FGF7 GeneProduct ensembl:ENSG00000140285
VSX2 GeneProduct ensembl:ENSG00000119614 Hox10
WNT5A GeneProduct ensembl:ENSG00000114251
LHX1 GeneProduct ensembl:ENSG00000273706
SIX1 GeneProduct ensembl:ENSG00000126778
NT5E GeneProduct ensembl:ENSG00000135318 membrane-bound enzyme ecto-50-nucleotidase (50NT)
SIX2 GeneProduct ensembl:ENSG00000170577
OSR1 GeneProduct ensembl:ENSG00000143867 Confirmed in mouse yet
PAX2 GeneProduct ensembl:ENSG00000075891
NPHS1 GeneProduct ensembl:ENSG00000161270
SMAD5 GeneProduct ensembl:ENSG00000113658
ALDH1A2 GeneProduct ensembl:ENSG00000128918 also known as RALDH2
VSX2 GeneProduct ensembl:ENSG00000119614 alternative name HOX10
TLX1 GeneProduct ensembl:ENSG00000107807 alternative name HOX11
EGLN2 GeneProduct ensembl:ENSG00000269858 PHD1
EGLN3 GeneProduct ensembl:ENSG00000129521 PHD3
BMP4 GeneProduct ensembl:ENSG00000125378
TNC GeneProduct ensembl:ENSG00000041982 Tenascin C
FAT4 GeneProduct ensembl:ENSG00000196159
ALDH1A2 GeneProduct ensembl:ENSG00000128918
NTN1 GeneProduct ensembl:ENSG00000065320 Netrin 1
DCN GeneProduct ensembl:ENSG00000011465
PDGFRB GeneProduct ensembl:ENSG00000113721 Tenascin C
CTNNB1 GeneProduct ensembl:ENSG00000168036
RARA GeneProduct ensembl:ENSG00000131759
TGFB1 GeneProduct ensembl:ENSG00000105329
RARB GeneProduct ensembl:ENSG00000077092

References

  1. Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2. Hatini V, Huh SO, Herzlinger D, Soares VC, Lai E. Genes Dev. 1996 Jun 15;10(12):1467–78. PubMed Europe PMC Scholia
  2. Secreted Frizzled-related proteins can regulate metanephric development. Yoshino K, Rubin JS, Higinbotham KG, Uren A, Anest V, Plisov SY, et al. Mech Dev. 2001 Apr;102(1–2):45–55. PubMed Europe PMC Scholia
  3. Pbx1 regulates nephrogenesis and ureteric branching in the developing kidney. Schnabel CA, Godin RE, Cleary ML. Dev Biol. 2003 Feb 15;254(2):262–76. PubMed Europe PMC Scholia
  4. c-kit delineates a distinct domain of progenitors in the developing kidney. Schmidt-Ott KM, Chen X, Paragas N, Levinson RS, Mendelsohn CL, Barasch J. Dev Biol. 2006 Nov 1;299(1):238–49. PubMed Europe PMC Scholia
  5. Cited1 and Cited2 are differentially expressed in the developing kidney but are not required for nephrogenesis. Boyle S, Shioda T, Perantoni AO, de Caestecker M. Dev Dyn. 2007 Aug;236(8):2321–30. PubMed Europe PMC Scholia
  6. Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia. Boyle S, Misfeldt A, Chandler KJ, Deal KK, Southard-Smith EM, Mortlock DP, et al. Dev Biol. 2008 Jan 1;313(1):234–45. PubMed Europe PMC Scholia
  7. Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Kobayashi A, Valerius MT, Mugford JW, Carroll TJ, Self M, Oliver G, et al. Cell Stem Cell. 2008 Aug 7;3(2):169–81. PubMed Europe PMC Scholia
  8. Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney. Mugford JW, Sipilä P, McMahon JA, McMahon AP. Dev Biol. 2008 Dec 1;324(1):88–98. PubMed Europe PMC Scholia
  9. Paraxial mesoderm contributes stromal cells to the developing kidney. Guillaume R, Bressan M, Herzlinger D. Dev Biol. 2009 May 15;329(2):169–75. PubMed Europe PMC Scholia
  10. Hox10 genes function in kidney development in the differentiation and integration of the cortical stroma. Yallowitz AR, Hrycaj SM, Short KM, Smyth IM, Wellik DM. PLoS One. 2011;6(8):e23410. PubMed Europe PMC Scholia
  11. Genes that confer the identity of the renin cell. Brunskill EW, Sequeira-Lopez MLS, Pentz ES, Lin E, Yu J, Aronow BJ, et al. J Am Soc Nephrol. 2011 Dec;22(12):2213–25. PubMed Europe PMC Scholia
  12. Tbx18 expression demarcates multipotent precursor populations in the developing urogenital system but is exclusively required within the ureteric mesenchymal lineage to suppress a renal stromal fate. Bohnenpoll T, Bettenhausen E, Weiss AC, Foik AB, Trowe MO, Blank P, et al. Dev Biol. 2013 Aug 1;380(1):25–36. PubMed Europe PMC Scholia
  13. Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin. Kobayashi H, Liu Q, Binns TC, Urrutia AA, Davidoff O, Kapitsinou PP, et al. J Clin Invest. 2016 May 2;126(5):1926–38. PubMed Europe PMC Scholia
  14. Cycles of vascular plexus formation within the nephrogenic zone of the developing mouse kidney. Munro DAD, Hohenstein P, Davies JA. Sci Rep. 2017 Jun 12;7(1):3273. PubMed Europe PMC Scholia
  15. Macrophages restrict the nephrogenic field and promote endothelial connections during kidney development. Munro DA, Wineberg Y, Tarnick J, Vink CS, Li Z, Pridans C, et al. Elife. 2019 Feb 13;8:e43271. PubMed Europe PMC Scholia
  16. The origin and role of the renal stroma. Wilson SB, Little MH. Development. 2021 Oct 1;148(19):dev199886. PubMed Europe PMC Scholia
  17. Heterozygous variants in the DVL2 interaction region of DACT1 cause CAKUT and features of Townes-Brocks syndrome 2. Christians A, Kesdiren E, Hennies I, Hofmann A, Trowe MO, Brand F, et al. Hum Genet. 2023 Jan;142(1):73–88. PubMed Europe PMC Scholia
  18. Heterozygous variants in the teashirt zinc finger homeobox 3 (TSHZ3) gene in human congenital anomalies of the kidney and urinary tract. Kesdiren E, Martens H, Brand F, Werfel L, Wedekind L, Trowe MO, et al. Eur J Hum Genet. 2024 Oct 17;10.1038/s41431-024-01710-y. PubMed Europe PMC Scholia