Mitochondrial complex III assembly (WP4921)

Homo sapiens

Open in new tab Open in NDEx Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Complex III or quinol-cytochrome c reductase performs electron transfer coupled to proton pumping. It occurs as a symmetrical, tightly bound dimer (referred to as cIII2). This dimerisation occurs prior to the pre CIII complex formation, annotated as pre-CIII(2). Each monomer is composed of a catalytic core containing MT-CYB, CYC1 and UQCRFS1. An additional seven subunits are required for stability and/or correct assembly of the enzyme, but are not involved in the catalysis, but .

Authors

Anna Baya Meuleman and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

electron transport chain pathway oxidative phosphorylation pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
heme b Metabolite chebi:60344
2Fe-2S Metabolite chebi:30408
UQCC3 GeneProduct ensembl:ENSG00000204922
UQCC2 GeneProduct ensembl:ENSG00000137288
UQCRH GeneProduct ensembl:ENSG00000173660
UQCRC2 GeneProduct ensembl:ENSG00000140740
LYRM7 GeneProduct ensembl:ENSG00000186687
UQCR11 GeneProduct ensembl:ENSG00000127540
UQCRB GeneProduct ensembl:ENSG00000156467
UQCRC1 GeneProduct ensembl:ENSG00000010256
MT-CYB GeneProduct ensembl:ENSG00000198727
UQCRQ GeneProduct ensembl:ENSG00000164405
UQCRFS1 GeneProduct ensembl:ENSG00000169021
CYC1 GeneProduct ensembl:ENSG00000179091
BCS1L GeneProduct ensembl:ENSG00000074582
UQCC1 GeneProduct ensembl:ENSG00000101019
TTC19 GeneProduct ensembl:ENSG00000011295
UQCR10 GeneProduct ensembl:ENSG00000184076

References

  1. Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. Signes A, Fernandez-Vizarra E. Essays Biochem. 2018 Jul 20;62(3):255–70. PubMed Europe PMC Scholia