AKT signaling and ARTD family members (WP5531)

Homo sapiens

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There are only a few conflicting findings regarding the regulation of ARTD family members by AKT signaling. In one type of astrocyte, seizure induction increased both PARP1 levels and enzymatic activity, whereas in another type, seizures resulted in a decrease in PARP1 and its activity. In both scenarios, inhibiting AKT signaling reduced PARP1 protein levels and activity. This suggests that AKT may play a role in promoting PARP1 expression and signaling. Inspired by figure 5 in Boehi et al. (2021).

Authors

Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
GSK3B GeneProduct ensembl:ENSG00000082701
PHLPP1 GeneProduct ensembl:ENSG00000081913
PDK1 GeneProduct ensembl:ENSG00000152256
TSC1 GeneProduct ensembl:ENSG00000165699
FOXO1 GeneProduct ensembl:ENSG00000150907
SIRT1 GeneProduct ensembl:ENSG00000096717
PARP1 GeneProduct ensembl:ENSG00000143799
PARP2 GeneProduct ensembl:ENSG00000129484
PARP3 GeneProduct ensembl:ENSG00000041880
TSC2 GeneProduct ensembl:ENSG00000103197
PIK3CA GeneProduct ensembl:ENSG00000121879
PIK3CB GeneProduct ensembl:ENSG00000051382
PIK3CG GeneProduct ensembl:ENSG00000105851
PIK3CD GeneProduct ensembl:ENSG00000171608
PIK3R1 GeneProduct ensembl:ENSG00000145675
PIK3R2 GeneProduct ensembl:ENSG00000105647
PIK3R3 GeneProduct ensembl:ENSG00000117461
PIK3R4 GeneProduct ensembl:ENSG00000196455
PIK3R5 GeneProduct ensembl:ENSG00000141506
PIK3R6 GeneProduct ensembl:ENSG00000276231
PIK3C2A GeneProduct ensembl:ENSG00000011405
PIK3C2B GeneProduct ensembl:ENSG00000133056
PIK3C2G GeneProduct ensembl:ENSG00000139144
RPTOR GeneProduct ensembl:ENSG00000141564
MTOR GeneProduct ensembl:ENSG00000198793
MLST8 GeneProduct ensembl:ENSG00000167965
RICTOR GeneProduct ensembl:ENSG00000164327
MAPKAP1 GeneProduct ensembl:ENSG00000119487
AKT1 GeneProduct ensembl:ENSG00000142208
AKT2 GeneProduct ensembl:ENSG00000105221
AKT3 GeneProduct ensembl:ENSG00000117020
IKBKG GeneProduct ensembl:ENSG00000269335
ATM GeneProduct ensembl:ENSG00000149311

References

  1. Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses. Boehi F, Manetsch P, Hottiger MO. Cell Discov. 2021 Nov 2;7(1):104. PubMed Europe PMC Scholia