Trans-sulfuration pathway (WP2333)
Homo sapiens
Trans-sulfuration pathway, the pathway of production of GSH from S-adenosylmethionine (SAMe). Evidences have been showed that this pathway was perturbed in liver toxicity studies.
Authors
Liang Zhao and Martina Summer-KutmonActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
glutathione metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Tetrahydrofolate (THF) | Metabolite | kegg.compound:C00101 | |
| L-Methionine | Metabolite | kegg.compound:C00073 | |
| 5-Methyl-THF | Metabolite | kegg.compound:C00440 | |
| L-Homocysteine | Metabolite | kegg.compound:C00155 | |
| S-Adenosylmethionine (SAMe) | Metabolite | kegg.compound:C00019 | |
| S-Adenosylhomocysteine (SAH) | Metabolite | kegg.compound:C00021 | |
| L-Cysteine | Metabolite | kegg.compound:C00097 | |
| Glutathione | Metabolite | kegg.compound:C00051 | |
| Taurine | Metabolite | kegg.compound:C00245 | |
| L-Glutamate | Metabolite | kegg.compound:C00025 | |
| Pyruvate | Metabolite | kegg.compound:C00022 | |
| ATP | Metabolite | kegg.compound:C00002 | |
| ADP | Metabolite | kegg.compound:C00008 | |
| Phosphate | Metabolite | kegg.compound:C00009 | |
| MTR | GeneProduct | ncbigene:4548 | |
| MAT2B | GeneProduct | ncbigene:27430 | |
| DNMT1 | GeneProduct | ncbigene:1786 | |
| AHCY | GeneProduct | ncbigene:191 | |
| CBS | GeneProduct | ncbigene:875 | |
| CTH | GeneProduct | ncbigene:1491 | |
| CTH | GeneProduct | ncbigene:1491 | |
| GOT1 | GeneProduct | ncbigene:2805 | |
| MPST | GeneProduct | ncbigene:4357 | |
| GCLM | GeneProduct | ncbigene:2730 | |
| CSAD | GeneProduct | ncbigene:51380 | |
| GCLM | GeneProduct | ncbigene:2730 |
References
- Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity. Beger RD, Sun J, Schnackenberg LK. Toxicol Appl Pharmacol. 2010 Mar 1;243(2):154–66. PubMed Europe PMC Scholia