mir-124 predicted interactions with cell cycle and differentiation (WP3595)

Homo sapiens

Open in new tab Open in NDEx Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Schematic of predicted interactions of miR-124 with cell cycle and cell differentiation machinery. A genomewide miRNA mimic toxicity screen indicates common and selective vulnerabilities of epithelial ovarian cancer cells. miR-124 is selectively toxic, mainly by inducing terminal cell differentiation via its target SIX4.

Authors

Kristina Hanspers , Ryan Miller , and Martina Summer-Kutmon

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

ExRNA

Annotations

Pathway Ontology

regulatory pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
SIX4 GeneProduct ensembl:ENSG00000100625
STRADB GeneProduct ensembl:ENSG00000082146
KLB1 GeneProduct ensembl:ENSG00000118046
AMPK GeneProduct ensembl:ENSG00000132356
PTBP GeneProduct ensembl:ENSG00000011304
SCP1 GeneProduct ensembl:ENSG00000144579

References

  1. A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression. Shields BB, Pecot CV, Gao H, McMillan E, Potts M, Nagel C, et al. Mol Syst Biol. 2015 Dec 11;11(12):842. PubMed Europe PMC Scholia