AMPK regulation of mammary milk protein synthesis (WP5492)
Homo sapiens
"AMPK regulates mammary milk protein synthesis: mTORC1 is the master regulator that controls milk protein synthesis in the mammary gland through 4EBP1 and S6K1. AMPK directly inhibits mTORC1 through the phosphorylation of raptor at Ser 792. AMPK also decreases mTOR activity through the phosphorylation of TSC2 (a negative mTORC1 regulator) at Ser1345. The genes encoding as1-casein (CSN1S1), β-casein (CSN2) and κ-casein (CSN3) are also decreased with the activation of AMPK." Derived from Figure 4 in https://pmc.ncbi.nlm.nih.gov/articles/PMC7332552.
Authors
Eric WeitzActivity
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Cited In
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayCell Type Ontology
mammary gland epithelial cell| Label | Type | Compact URI | Comment |
|---|---|---|---|
| PRKAA1 | GeneProduct | ensembl:ENSG00000132356 | |
| PRKAA2 | GeneProduct | ensembl:ENSG00000162409 | |
| PRKAB1 | GeneProduct | ensembl:ENSG00000111725 | |
| PRKAB2 | GeneProduct | ensembl:ENSG00000131791 | |
| PRKAG1 | GeneProduct | ensembl:ENSG00000181929 | |
| PRKAG2 | GeneProduct | ensembl:ENSG00000106617 | |
| PRKAG3 | GeneProduct | ensembl:ENSG00000115592 | |
| RPTOR | GeneProduct | ensembl:ENSG00000141564 | |
| MTOR | GeneProduct | ensembl:ENSG00000198793 | |
| MLST8 | GeneProduct | ensembl:ENSG00000167965 | |
| EIF4EBP1 | GeneProduct | ensembl:ENSG00000198793 | '4EBP1' in source |
| EIF4E | GeneProduct | ensembl:ENSG00000151247 | |
| EIF4G1 | GeneProduct | ensembl:ENSG00000114867 | |
| EIF4A2 | GeneProduct | ensembl:ENSG00000156976 | 'EIF4A' in source |
| TSC2 | GeneProduct | ensembl:ENSG00000103197 | |
| RHEB | GeneProduct | ensembl:ENSG0000010661 | |
| RPS6KB1 | GeneProduct | ensembl:ENSG00000108443 | |
| EEF2K | GeneProduct | ensembl:ENSG00000103319 | |
| EEF2 | GeneProduct | ensembl:ENSG00000167658 | |
| CSN1S1 | GeneProduct | ensembl:ENSG00000126545 | |
| CSN2 | GeneProduct | ensembl:ENSG00000135222 | |
| CSN3 | GeneProduct | ensembl:ENSG00000171209 |
References
- Current Evidences and Future Perspectives for AMPK in the Regulation of Milk Production and Mammary Gland Biology. Wu Z, Tian M, Heng J, Chen J, Chen F, Guan W, et al. Front Cell Dev Biol. 2020 Jun 26;8:530. PubMed Europe PMC Scholia