MAP3K1 role in promoting and blocking gonadal determination (WP4872)

Homo sapiens

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This pathway summarizes the differential signaling in sex development in the human fetus. Disorders of sex development can derive from dysfunction of one or more genes in this pathway.

Authors

Yves Tilmans , Friederike Ehrhart , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

46 XX gonadal dysgenesis 46,XY sex reversal gonadal dysgenesis

Pathway Ontology

signaling pathway pertinent to development signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
MAPK1 GeneProduct ensembl:ENSG00000100030
WNT4 GeneProduct ensembl:ENSG00000162552
MAP3K4 GeneProduct ensembl:ENSG00000085511
ROCK1 GeneProduct ensembl:ENSG00000067900
MAP3K1 GeneProduct ensembl:ENSG00000095015
FGFR2 GeneProduct ensembl:ENSG00000066468
AXIN1 GeneProduct ensembl:ENSG00000103126
FRAT1 GeneProduct ensembl:ENSG00000165879
RHOA GeneProduct ensembl:ENSG00000067560
SOX9 GeneProduct ensembl:ENSG00000125398
FOXL2 GeneProduct ensembl:ENSG00000183770
MAPK11 GeneProduct ensembl:ENSG00000185386
GSK3B GeneProduct ensembl:ENSG00000082701
GADD45G GeneProduct ensembl:ENSG00000130222
SRY GeneProduct ensembl:ENSG00000184895
FGF9 GeneProduct ensembl:ENSG00000102678
CTNNB1 Protein uniprot:B4DGU4

References

  1. Disorders of sex development (DSDs): an update. Ostrer H. J Clin Endocrinol Metab. 2014 May;99(5):1503–9. PubMed Europe PMC Scholia