let-7 inhibition of ES cell reprogramming (WP3299)
Homo sapiens
Four transcription factors (OCT4, KLF4, SOX2, and c-MYC) reprogram adult cells into stem cells. MicroRNA let-7 is a barrier to reprogramming that inhibits LIN-41, a strong reprogramming factor that is expressed in pluripotent embryonic stem cells. LIN-41 inhibits the transcription factor EGR1, which promotes cell differentiation and is another barrier to reprogramming. (Description from Worringer et al)
Authors
Kristina Hanspers and Jonathan MéliusActivity
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Cited In
- ACE2 correlates with immune infiltrates in colon adenocarcinoma: Implication for COVID-19 (2021).
- The differential expression of adipose tissue genes in short, medium and long-term periods after bariatric surgery (2024).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
regulatory pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| c-MYC | GeneProduct | ensembl:ENSG00000136997 | |
| LIN-41 | GeneProduct | ensembl:ENSG00000206557 | |
| EGR1 | GeneProduct | ensembl:ENSG00000120738 | |
| MIRLET7A1 | GeneProduct | ensembl:ENSG00000199165 | |
| SOX2 | GeneProduct | ensembl:ENSG00000181449 | |
| KLF4 | GeneProduct | ensembl:ENSG00000136826 | |
| OCT4 | GeneProduct | ncbigene:5460 | |
| MIRLET7A2 | GeneProduct | ensembl:ENSG00000198975 | |
| MIRLET7A3 | GeneProduct | ensembl:ENSG00000198986 | |
| MIRLET7C | GeneProduct | ensembl:ENSG00000199030 | |
| MIRLET7D | GeneProduct | ensembl:ENSG00000199133 | |
| MIRLET7E | GeneProduct | ensembl:ENSG00000198972 | |
| MIRLET7F1 | GeneProduct | ensembl:ENSG00000199072 | |
| MIRLET7F2 | GeneProduct | ensembl:ENSG00000208012 | |
| MIRLET7G | GeneProduct | ensembl:ENSG00000199150 | |
| MIRLET7I | GeneProduct | ensembl:ENSG00000199179 |
References
- The let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes. Worringer KA, Rand TA, Hayashi Y, Sami S, Takahashi K, Tanabe K, et al. Cell Stem Cell. 2014 Jan 2;14(1):40–52. PubMed Europe PMC Scholia