Hippo-YAP signaling (WP4537)
Homo sapiens
When the Hippo-YAP pathway is in the "ON" state, YAP and TAZ are phosphorylated and held in cytoplasm. When the pathway is in the "OFF" state, unphosphorylated YAP and TAZ accumulate in the nucleus with TEAD. This pathway was created based on figure 1 from Zhou et al. Phosphorylatin sites were added based on information from PhosphoSitePlus, www.phosphosite.org.
Authors
Martina Summer-Kutmon , Eric Weitz , and Kristina HanspersActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
Hippo signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| CXCL10 | GeneProduct | ncbigene:3627 | MOB1 |
| STK3 | GeneProduct | ncbigene:6788 | MST1/2 |
| STK38L | GeneProduct | ncbigene:23012 | NDR1/2 |
| SAV1 | GeneProduct | ncbigene:60485 | SAV1 |
| LATS1 | GeneProduct | ncbigene:9113 | LATS1/2 |
| YAP1 | GeneProduct | ncbigene:10413 | YAP/TAZ |
| MINK1 | GeneProduct | ensembl:ENSG00000141503 | |
| TNIK | GeneProduct | ensembl:ENSG00000154310 | |
| NF2 | GeneProduct | ncbigene:4771 | Nf2 |
| LATS2 | GeneProduct | ncbigene:26524 | LATS1/2 |
| NDRG1 | GeneProduct | ncbigene:10397 | NDR1/2 |
| RASSF1 | GeneProduct | ensembl:ENSG00000068028 | |
| WWTR1 | GeneProduct | ncbigene:25937 | YAP/TAZ |
| STK4 | GeneProduct | ncbigene:4485 | MST1/2 |
| MAP4K1 | GeneProduct | ensembl:ENSG00000104814 | |
| MAP4K2 | GeneProduct | ensembl:ENSG00000168067 | |
| MAP4K4 | GeneProduct | ensembl:ENSG00000071054 | |
| MAP4K3 | GeneProduct | ensembl:ENSG00000011566 | |
| TEAD1 | GeneProduct | ensembl:ENSG00000187079 | |
| TEAD2 | GeneProduct | ensembl:ENSG00000074219 | |
| TEAD3 | GeneProduct | ensembl:ENSG00000007866 | |
| TEAD4 | GeneProduct | ensembl:ENSG00000197905 | |
| 14-3-3 | Protein | pfam:PF00244 |
References
- How Hippo Signaling Pathway Modulates Cardiovascular Development and Diseases. Zhou W, Zhao M. J Immunol Res. 2018 Feb 8;2018:3696914. PubMed Europe PMC Scholia