Wnt/beta-catenin signaling in leukemia (WP3658)
Homo sapiens
The Wnt/Beta-catenin pathway mediates the transcription of proteins important for maintenance and growth of hematopoietic stem cells. The inhibition of Wnt leads to protein degradation through Beta-Catenin activation by the Axin/APC/CK1/GSK3B protein complex. This pathway is based on figure 5 from Misaghian et al. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3658 CPTAC Assay Portal]
Authors
AAR&Co , Linda Rieswijk , Kristina Hanspers , Mick Eikelhof , Andika Tan , and Eric WeitzActivity
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Cited In
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Organisms
Homo sapiensCommunities
CPTAC DiseasesAnnotations
Disease Ontology
leukemiaPathway Ontology
altered Wnt signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Phosphate | Metabolite | hmdb:HMDB0001429 | |
| DKK | GeneProduct | ensembl:ENSG00000107984 | DKK Not Specified |
| c-MYC | GeneProduct | ensembl:ENSG00000136997 | |
| AML1 | GeneProduct | ensembl:LRG_482 | |
| TCF | GeneProduct | ensembl:ENSG00000071564 | TCF Not Specified |
| LEF | GeneProduct | ensembl:ENSG00000138795 | LEF Not Specified |
| PPARD | GeneProduct | ensembl:ENSG00000112033 | |
| GSK3B | GeneProduct | ensembl:ENSG00000082701 | |
| WNT | GeneProduct | ensembl:ENSG00000125084 | Wnt Not Specified |
| RARA | GeneProduct | ensembl:ENSG00000131759 | |
| PLZF | GeneProduct | ensembl:ENSG00000109906 | |
| BCL9 | GeneProduct | ensembl:ENSG00000116128 | |
| RUNX1T1 | GeneProduct | ensembl:ENSG00000079102 | |
| FLT3 | GeneProduct | ensembl:ENSG00000122025 | |
| PML | GeneProduct | ensembl:ENSG00000140464 | |
| AKT | GeneProduct | ensembl:ENSG00000142208 | Akt Not Specified |
| LRP6 | GeneProduct | ensembl:ENSG00000070018 | |
| APC | GeneProduct | ensembl:ENSG00000134982 | |
| CK1 | GeneProduct | ensembl:ENSG00000113712 | |
| LRP5 | GeneProduct | ensembl:ENSG00000162337 | |
| WIF1 | GeneProduct | ensembl:ENSG00000156076 | |
| AXIN | GeneProduct | ensembl:ENSG00000168646 | |
| SALL4 | GeneProduct | ensembl:ENSG00000101115 | |
| PYGO | GeneProduct | ensembl:ENSG00000171016 | PYGO Not Specified |
| Junction plakoglobin | Protein | uniprot:P14923 | |
| Frizzled | Protein | uniprot:E5RGK8 | Frizzled Not Specified |
| cyclin-D1 | Protein | uniprot:P24385 | |
| Catenin beta-1 | Protein | uniprot:B4DGU4 |
References
- Targeting the leukemic stem cell: the Holy Grail of leukemia therapy. Misaghian N, Ligresti G, Steelman LS, Bertrand FE, Bäsecke J, Libra M, et al. Leukemia. 2009 Jan;23(1):25–42. PubMed Europe PMC Scholia