Mitochondrial complex IV assembly (WP4922)

Homo sapiens

Open in new tab Open in NDEx Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Complex IV or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation. Mammalian cIV contains 13 subunits. MT-CO1 is the largest catalytic subunit. MT-CO2 is the second core subunit. MT-CO3, the third core subunit has no direct catalytic role. The supernumerary subunits do not seem to have a catalytic role, but are thought to be important for the stabilization and regulation of the catalytic core. Complex IV is the only OXPHOS complex containing tissue-specific and developmentally regulated isoforms.

Authors

Anna Baya Meuleman , Marvin Martens , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

electron transport chain pathway oxidative phosphorylation pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Copper Metabolite chebi:30052
Heme O Metabolite chebi:24480
Heme A Metabolite chebi:24479
Heme B Metabolite chebi:26355
PET100 GeneProduct ensembl:ENSG00000229833
COX6C GeneProduct ensembl:ENSG00000164919
COX5B GeneProduct ensembl:ENSG00000135940
HIGD1A GeneProduct ensembl:ENSG00000181061
MT-CO2 GeneProduct ensembl:ENSG00000198712
CMC1 GeneProduct ensembl:ENSG00000187118
SURF1 GeneProduct ensembl:ENSG00000148290
COX7B GeneProduct ensembl:ENSG00000131174
COX6B1 GeneProduct ensembl:ENSG00000126267
COX16 GeneProduct ensembl:ENSG00000133983
SMIM20 GeneProduct ensembl:ENSG00000250317
COX7A2 GeneProduct ensembl:ENSG00000112695
COA3 GeneProduct ensembl:ENSG00000183978
COX19 GeneProduct ensembl:ENSG00000240230
COA6 GeneProduct ensembl:ENSG00000168275
COX18 GeneProduct ensembl:ENSG00000163626
COX6A1 GeneProduct ensembl:ENSG00000111775
SCO2 GeneProduct ensembl:ENSG00000130489
COX15 GeneProduct ensembl:ENSG00000014919
PET117 GeneProduct ensembl:ENSG00000232838
COX11 GeneProduct ensembl:ENSG00000166260
TACO1 GeneProduct ensembl:ENSG00000136463
COX5A GeneProduct ensembl:ENSG00000178741
COX8A GeneProduct ensembl:ENSG00000176340
COX7C GeneProduct ensembl:ENSG00000127184
NDUFA4 GeneProduct ensembl:ENSG00000189043
TMEM177 GeneProduct ensembl:ENSG00000144120
COX14 GeneProduct ensembl:ENSG00000178449
MT-CO1 GeneProduct ensembl:ENSG00000198804
COX17 GeneProduct ensembl:ENSG00000138495
MT-CO3 GeneProduct ensembl:ENSG00000198938
COX4I1 GeneProduct ensembl:ENSG00000131143
COX10 GeneProduct ensembl:ENSG00000006695
COX20 GeneProduct ensembl:ENSG00000203667
PNKD GeneProduct ensembl:ENSG00000127838

References

  1. Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. Signes A, Fernandez-Vizarra E. Essays Biochem. 2018 Jul 20;62(3):255–70. PubMed Europe PMC Scholia