IL17 signaling (WP2112)

Homo sapiens

Open in new tab Open in NDEx Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Interleukin 17 is a family of cytokines that acts as potent mediators in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation, similar to Interferon gamma. IL-17 is produced by T-helper cells and is induced by IL-23 which results in destructive tissue damage in delayed-type reactions. Interleukin 17 as a family functions as proinflammatory cytokines that responds to the invasion of the immune system by extracellular pathogens. Interleukin 17 acts synergistically with tumor necrosis factor and interleukin-1. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2112 CPTAC Assay Portal]

Authors

Shamith Samarajiwa , Kristina Hanspers , Martina Summer-Kutmon , Ryan Miller , Alex Pico , Andra Waagmeester , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

cytokine mediated signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
TRAF6 GeneProduct ncbigene:7189
IL17RD GeneProduct ncbigene:54756
IKBKG GeneProduct ncbigene:8517
MAPK1 GeneProduct ncbigene:5594 p38
RELA GeneProduct ncbigene:5970
GSK3B GeneProduct ncbigene:2932
SP1 GeneProduct ncbigene:6667
NFKB1 GeneProduct ncbigene:4790
IL17RE GeneProduct ncbigene:132014
IL17A GeneProduct ncbigene:3605
AKT1 GeneProduct ncbigene:207
IL17F GeneProduct ncbigene:112744
TRAF3IP2 GeneProduct ncbigene:10758
JAK2 GeneProduct ncbigene:3717
IKBKB GeneProduct ncbigene:3551
IL17D GeneProduct ncbigene:53342
STAT3 GeneProduct ncbigene:6774
NFKBIB GeneProduct ncbigene:4793
IL17C GeneProduct ncbigene:27189
IL25 GeneProduct ncbigene:64806
IL17RC GeneProduct ncbigene:84818
MAP3K7 GeneProduct ncbigene:6885
CEBPB GeneProduct ncbigene:1051
IL17RA GeneProduct ncbigene:23765
IL17RB GeneProduct ncbigene:55540
MAP3K14 GeneProduct ncbigene:9020 NIK or p38
IL17B GeneProduct ncbigene:27190
CEBPD GeneProduct ncbigene:1052
MAPK1 GeneProduct ncbigene:5594
JAK1 GeneProduct ncbigene:3716
TRAF3 GeneProduct ncbigene:7187
MAPK3 GeneProduct ncbigene:5595
PI3K Protein ncbigene:5290

References

  1. IL-17 family: cytokines, receptors and signaling. Gu C, Wu L, Li X. Cytokine. 2013 Nov;64(2):477–85. PubMed Europe PMC Scholia