Signal transduction through IL1R (WP4496)

Homo sapiens

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Signal transduction through IL1R. Pathway based on Biocarta pathway (M12095). https://cgap.nci.nih.gov/Pathways/BioCarta/h_il1rPathway IL-1 signals primarily through the IL-1 receptor type 1 (IL-1R1). Through expression of cytokines such as TNF, TGF-beta and interferons, IL-1 holds a range of inflammatory activities that include induction of fever, expression of vascular adhesion molecules and roles in arthritis and septic shock. IL-1 binds to the respective IL-1 receptor however, it requires the IL-1 receptor accessory protein (IL-1RAP) to transduce a signal. Two kinases (IRAK-1 and IRAK-2) get activated through IL-1 binding to its receptor. Via these kinases a cascade gets activated which includes TRAF6, NF-kB activation and c-JUN activation. The IL-1 signaling cascade represents a highly conserved response to pathogens.

Authors

Laurent Winckers , Friederike Ehrhart , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

immune response pathway signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
IFNA1 GeneProduct ncbigene:3439
IL6 GeneProduct ncbigene:3569
IRAK2 GeneProduct ncbigene:3656
IRAK3 GeneProduct ncbigene:11213
NFKB1 GeneProduct ncbigene:4790
NFKBIA GeneProduct ncbigene:4792
RELA GeneProduct ncbigene:5970
TGFB2 GeneProduct ncbigene:7042
TGFB3 GeneProduct ncbigene:7043
TNF GeneProduct ncbigene:7124
TOLLIP GeneProduct ncbigene:54472
MAP2K3 GeneProduct ncbigene:5606
TRAF6 GeneProduct ncbigene:7189
MAP3K1 GeneProduct ncbigene:4214
IKBKB GeneProduct ncbigene:3551
IRAK1 GeneProduct ncbigene:3654
MAPK8 GeneProduct ncbigene:5599
IFNB1 GeneProduct ncbigene:3456
MAP3K7 GeneProduct ncbigene:6885
MAP3K14 GeneProduct ncbigene:9020
MYD88 GeneProduct ncbigene:4615
TGFB1 GeneProduct ncbigene:7040
IL1RN GeneProduct ncbigene:3557
JUN GeneProduct ncbigene:3725
MAPK14 GeneProduct ncbigene:1432
CHUK GeneProduct ncbigene:1147
ECSIT GeneProduct ncbigene:51295
MAP2K6 GeneProduct ncbigene:5608
TAB1 GeneProduct ncbigene:10454
IL1RAP GeneProduct ncbigene:3556
IL1R1 GeneProduct ncbigene:3554
IL1A GeneProduct ncbigene:3552
IL1B GeneProduct ncbigene:3553

References

  1. Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants. O’Neill LA, Greene C. J Leukoc Biol. 1998 Jun;63(6):650–7. PubMed Europe PMC Scholia
  2. Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Cargnello M, Roux PP. Microbiol Mol Biol Rev. 2011 Mar;75(1):50–83. PubMed Europe PMC Scholia