Signal transduction through IL1R (WP4496)

Homo sapiens

Open in new tab Open in NDEx
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Signal transduction through IL1R. Pathway based on Biocarta pathway (M12095). https://cgap.nci.nih.gov/Pathways/BioCarta/h_il1rPathway IL-1 signals primarily through the IL-1 receptor type 1 (IL-1R1). Through expression of cytokines such as TNF, TGF-beta and interferons, IL-1 holds a range of inflammatory activities that include induction of fever, expression of vascular adhesion molecules and roles in arthritis and septic shock. IL-1 binds to the respective IL-1 receptor however, it requires the IL-1 receptor accessory protein (IL-1RAP) to transduce a signal. Two kinases (IRAK-1 and IRAK-2) get activated through IL-1 binding to its receptor. Via these kinases a cascade gets activated which includes TRAF6, NF-kB activation and c-JUN activation. The IL-1 signaling cascade represents a highly conserved response to pathogens.

Authors

Laurent Winckers and Friederike Ehrhart

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
IFNA1 GeneProduct ncbigene:3439
IL6 GeneProduct ncbigene:3569
IRAK2 GeneProduct ncbigene:3656
IRAK3 GeneProduct ncbigene:11213
NFKB1 GeneProduct ncbigene:4790
NFKBIA GeneProduct ncbigene:4792
RELA GeneProduct ncbigene:5970
TGFB1 GeneProduct ncbigene:7040
TGFB2 GeneProduct ncbigene:7042
TGFB3 GeneProduct ncbigene:7043
TNF GeneProduct ncbigene:7124
TOLLIP GeneProduct ncbigene:54472
MAP2K3 GeneProduct ncbigene:5606
TRAF6 GeneProduct ncbigene:7189
MAP3K1 GeneProduct ncbigene:4214
IKBKB GeneProduct ncbigene:3551
IRAK1 GeneProduct ncbigene:3654
MAPK8 GeneProduct ncbigene:5599
IFNB1 GeneProduct ncbigene:3456
MAP3K7 GeneProduct ncbigene:6885
MAP3K14 GeneProduct ncbigene:9020
MYD88 GeneProduct ncbigene:4615
IL1RN GeneProduct ncbigene:3557
JUN GeneProduct ncbigene:3725
MAPK14 GeneProduct ncbigene:1432
CHUK GeneProduct ncbigene:1147
ECSIT GeneProduct ncbigene:51295
MAP2K6 GeneProduct ncbigene:5608
TAB1 GeneProduct ncbigene:10454
IL1RAP GeneProduct ncbigene:3556
IL1R1 GeneProduct ncbigene:3554
IL1A GeneProduct ncbigene:3552
IL1B GeneProduct ncbigene:3553
IL1RAP GeneProduct ncbigene:3556
IL1R1 GeneProduct ncbigene:3554
IL1A GeneProduct ncbigene:3552
IL1B GeneProduct ncbigene:3553
MAP3K1 GeneProduct ncbigene:4214
NFKB1 GeneProduct ncbigene:4790
NFKBIA GeneProduct ncbigene:4792
RELA GeneProduct ncbigene:5970
JUN GeneProduct ncbigene:3725
IKBKB GeneProduct ncbigene:3551

References

  1. Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants. O’Neill LA, Greene C. J Leukoc Biol. 1998 Jun;63(6):650–7. PubMed Europe PMC Scholia
  2. Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Cargnello M, Roux PP. Microbiol Mol Biol Rev. 2011 Mar;75(1):50–83. PubMed Europe PMC Scholia