Ganglio series sphingolipid metabolism (WP5299)

Homo sapiens

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Ganglio- series of glycosphingolipids, biosynthesis

Authors

Conroy lipids , Alex Pico , Lars Willighagen , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

sphingolipid metabolic pathway ganglioside metabolic pathway lipid metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
GD3 Metabolite lipidmaps:LMSP0601AK00
GM2 Metabolite lipidmaps:LMSP0601AM00
GA2 Metabolite lipidmaps:LMSP0503AA00
GP1c Metabolite lipidmaps:LMSP0601AX00
GQ1b Metabolite lipidmaps:LMSP0601AV00
GT1c Metabolite lipidmaps:LMSP0601AR00
GM1b Metabolite lipidmaps:LMSP0601AY00
GM3 Metabolite lipidmaps:LMSP0601AJ00
GT2 Metabolite lipidmaps:LMSP0601AO00
GT1a Metabolite lipidmaps:LMSP0601AW00
GM1 Metabolite lipidmaps:LMSP0601AP00
GD1c Metabolite lipidmaps:LMSP0601BN00
GQ1c Metabolite lipidmaps:LMSP0601AU00
GD1a Metabolite lipidmaps:LMSP0601AS00
GD2 Metabolite lipidmaps:LMSP0601AN00
GM2a Metabolite lipidmaps:LMSP0601EK00
GA1/ Asialo-GM1 Metabolite lipidmaps:LMSP0503AB00
GT3 Metabolite lipidmaps:LMSP0601AL00
LacCer Metabolite lipidmaps:LMSP0501AB00
GD1b Metabolite lipidmaps:LMSP0601AQ00
GT1b Metabolite lipidmaps:LMSP0601AT00
HEXB GeneProduct uniprot:P07686
HEXA GeneProduct uniprot:P06865
ST8SIA1 GeneProduct uniprot:Q92185
ST8SIA6 GeneProduct uniprot:P61647
B3GALT4 GeneProduct uniprot:O96024
ST3GAL2 GeneProduct uniprot:Q16842
ST8SIA5 GeneProduct uniprot:O15466
ST3GAL4 GeneProduct uniprot:Q11206
B4GALNT1 GeneProduct uniprot:Q00973
NEU4 GeneProduct uniprot:Q8WWR8
NEU3 GeneProduct uniprot:Q9UQ49
ST3GAL5 GeneProduct uniprot:Q9UNP4
ST3GAL1 GeneProduct uniprot:Q11201

References

  1. Map 3: Biosynthetic Pathways of Glycosphingolipids. Inokuchi J ichi, Go S. In: Handbook of Glycosyltransferases and Related Genes [Internet]. Springer Japan; 2014. p. 1673–9. Available from: http://dx.doi.org/10.1007/978-4-431-54240-7_162 DOI Scholia
  2. Expression cloning of a human GT3 synthase. GD3 AND GT3 are synthesized by a single enzyme. Nakayama J, Fukuda MN, Hirabayashi Y, Kanamori A, Sasaki K, Nishi T, et al. J Biol Chem. 1996 Feb 16;271(7):3684–91. PubMed Europe PMC Scholia
  3. A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family. Amado M, Almeida R, Carneiro F, Levery SB, Holmes EH, Nomoto M, et al. J Biol Chem. 1998 May 22;273(21):12770–8. PubMed Europe PMC Scholia
  4. Evidence for mitochondrial localization of a novel human sialidase (NEU4). Yamaguchi K, Hata K, Koseki K, Shiozaki K, Akita H, Wada T, et al. Biochem J. 2005 Aug 15;390(Pt 1):85–93. PubMed Europe PMC Scholia
  5. SphinGOMAP--a web-based biosynthetic pathway map of sphingolipids and glycosphingolipids. Merril AH Jr. Glycobiology. 2005 Jun;15(6):15G. PubMed Europe PMC Scholia