Splicing factor NOVA regulated synaptic proteins (WP4148)

Homo sapiens

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Synaptic Communication influenced by NOVA-splicing regulation. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP4148 CPTAC Assay Portal].

Authors

Martina Summer-Kutmon , Kristina Hanspers , and Friederike Ehrhart

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

cadherin mediated signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
PIP2 Metabolite hmdb:HMDB0010032
PIP2 Metabolite hmdb:HMDB0010032
CAV2 GeneProduct ensembl:ENSG00000105971 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000000058
EPB41L2 GeneProduct ensembl:ENSG00000079819 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13822
MAPK4 GeneProduct ensembl:ENSG00000141639 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024558
CDH2 GeneProduct ensembl:ENSG00000170558 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12558
SNW1 GeneProduct ensembl:ENSG00000100603 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66354
CLSTN1 GeneProduct ensembl:ENSG00000171603 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:65945
KCNJ6 GeneProduct ensembl:ENSG00000157542 CLIP predicted target
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16522
CLASP1 GeneProduct ensembl:ENSG00000074054 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000064302
KCNMA1 GeneProduct ensembl:ENSG00000156113 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16531
CASK GeneProduct ensembl:ENSG00000147044 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031012
NCDN GeneProduct ensembl:ENSG00000020129 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26562
GABRG2 GeneProduct ensembl:ENSG00000113327 Validated target
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14406
MAPK9 GeneProduct ensembl:ENSG00000050748 Validated target - predicted by CLIP
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26420
ATP2B1 GeneProduct ensembl:ENSG00000070961 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67972
PLCB4 GeneProduct ensembl:ENSG00000101333 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000039943
RAP1GAP GeneProduct ensembl:ENSG00000076864 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110351
STX2 GeneProduct ensembl:ENSG00000111450 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13852
CAMK2G GeneProduct ensembl:ENSG00000148660 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021820
CADM1 GeneProduct ensembl:ENSG00000182985 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:54725
NEO1 GeneProduct ensembl:ENSG00000067141 Validated target - predicted by CLIP
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18007
CAV2 GeneProduct ensembl:ENSG00000105971 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000000058
CASK GeneProduct ensembl:ENSG00000147044 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031012
GPHN GeneProduct ensembl:ENSG00000171723 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:268566
DAB1 GeneProduct ensembl:ENSG00000173406 Validated target - predicted by bioinformatics
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028519
APLP2 GeneProduct ensembl:ENSG00000084234 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031996
KCNQ2 GeneProduct ensembl:ENSG00000075043 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000016346
STXBP2 GeneProduct ensembl:ENSG00000076944 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20911
EPB41 GeneProduct ensembl:ENSG00000159023 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:269587
EPB41L3 GeneProduct ensembl:ENSG00000082397 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13823
CHL1 GeneProduct ensembl:ENSG00000134121 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030077
NTNG1 GeneProduct ensembl:ENSG00000162631 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80883
TERF2IP GeneProduct ensembl:ENSG00000166848 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:57321
EFNA5 GeneProduct ensembl:ENSG00000184349 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13640
GRIN2B GeneProduct ensembl:ENSG00000273079 CLIP predicted target
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14812
GRIN1 GeneProduct ensembl:ENSG00000176884 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14810
CHL1 GeneProduct ensembl:ENSG00000134121 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030077
CDH2 GeneProduct ensembl:ENSG00000170558 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12558
ANK3 GeneProduct ensembl:ENSG00000151150 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11735
CASK GeneProduct ensembl:ENSG00000147044 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031012
DAB1 GeneProduct ensembl:ENSG00000173406 Validated target - predicted by bioinformatics
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028519
GRIK2 GeneProduct ensembl:ENSG00000164418 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14806
CASK GeneProduct ensembl:ENSG00000147044 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031012
PRKCZ GeneProduct ensembl:ENSG00000067606 CLIP predicted target
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18762
GABBR2 GeneProduct ensembl:ENSG00000136928 CLIP predicted target
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:242425
PLCB4 GeneProduct ensembl:ENSG00000101333 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000039943
ANK3 GeneProduct ensembl:ENSG00000151150 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11735
ANK3 GeneProduct ensembl:ENSG00000151150 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11735
MAPK9 GeneProduct ensembl:ENSG00000050748 Validated target - predicted by CLIP
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26420
EPB41 GeneProduct ensembl:ENSG00000159023 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:269587
EPB41 GeneProduct ensembl:ENSG00000159023 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:269587
GRIK2 GeneProduct ensembl:ENSG00000164418 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14806
KCNMA1 GeneProduct ensembl:ENSG00000156113 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16531
PRKCZ GeneProduct ensembl:ENSG00000067606 CLIP predicted target
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18762
GABBR2 GeneProduct ensembl:ENSG00000136928 CLIP predicted target
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:242425
GPHN GeneProduct ensembl:ENSG00000171723 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:268566
PLCB4 GeneProduct ensembl:ENSG00000101333 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000039943
EPB41L1 GeneProduct ensembl:ENSG00000088367 Validated target - predicted by bioinformatics
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13821
CADM3 GeneProduct ensembl:ENSG00000162706 Validated target - predicted by bioinformatics
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:94332
MAP4 Protein ensembl:ENSG00000047849 Validated target - predicted by bioinformatics
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P27546
AGRN Protein ensembl:ENSG00000188157 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:A2ASQ1
CSN3 Protein ensembl:ENSG00000171209 Validated target - predicted by splicing microarray
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P06796

References

  1. Nova regulates brain-specific splicing to shape the synapse. Ule J, Ule A, Spencer J, Williams A, Hu JS, Cline M, et al. Nat Genet. 2005 Aug;37(8):844–52. PubMed Europe PMC Scholia
  2. An RNA map predicting Nova-dependent splicing regulation. Ule J, Stefani G, Mele A, Ruggiu M, Wang X, Taneri B, et al. Nature. 2006 Nov 30;444(7119):580–6. PubMed Europe PMC Scholia