EPAC1 and PKA reduction of retinal inflammation (WP5440)

Homo sapiens

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Liu et al. (2022) note: "PKA and Epac1 regulated Nek7/NLRP3 signaling proteins. The schematic depicts the signaling pathway of PKA and Epac1 inhibition of Nek7 and NLRP3 signaling proteins to reduce retinal inflammation." This pathway diagram was derived from https://pfocr.wikipathways.org/figures/PMC8762717__iovs-63-1-14-f009.html.

Authors

Eric Weitz and Aishwarya Iyer

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

protein kinase A (PKA) signaling pathway

Disease Ontology

diabetic retinopathy

Participants
Query Drugst.One

Label Type Compact URI Comment
NEK7 GeneProduct ensembl:ENSG00000151414
EPAC1 GeneProduct ncbigene:10411
PRKACA GeneProduct ensembl:ENSG00000288516
PRKACB GeneProduct ensembl:ENSG00000142875
PRKAR1A GeneProduct ensembl:ENSG00000108946
NLRP3 GeneProduct ensembl:ENSG00000162711
IL1B GeneProduct ensembl:ENSG00000125538
PRKAR2B GeneProduct ensembl:ENSG00000188191
PRKAR2A GeneProduct ensembl:ENSG00000114302
PRKAR1B GeneProduct ensembl:ENSG00000188191

References

  1. PKA and Epac1 Reduce Nek7 to Block the NLRP3 Inflammasome Proteins in the Retinal Vasculature. Liu L, Jiang Y, Steinle JJ. Invest Ophthalmol Vis Sci. 2022 Jan 3;63(1):14. PubMed Europe PMC Scholia