EV release from cardiac cells and their functional effects (WP3297)

Homo sapiens

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Summary of reported extracellular vesicle (EV) release from cardiac cells in culture and their functional effects. EV release has been reported in numerous cell lines and primary cultures, both at baseline and in response to stimuli. Transfer of EVs between cell types has been demonstrated as well as delivery of cargo. Note that this pathway represents a review of multiple studies in multiple organisms. This pathway displays the human orthologs. HUVEC: human aortic endothelial cell HMEC-1: human microvascular endothelial cell HASMC: human aortic smooth muscle cell NRVM: neonatal rat ventricular myocyte. Adapted from Danielson KM, Das S. Extracellular Vesicles in Heart Disease: Excitement for the Future? Exosomes Microvesicles, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25429310

Authors

Kristina Hanspers , Susan Coort , Alex Pico , Marvin Martens , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

ExRNA

Annotations

Pathway Ontology

regulatory pathway

Cell Type Ontology

endothelial cell fibroblast monocyte cardiac muscle cell

Participants
Query Drugst.One

Label Type Compact URI Comment
Homocysteine Metabolite hmdb:HMDB0000742
Ox-LDL Metabolite chebi:60151
Ethanol Metabolite hmdb:HMDB0000108
Ethanol Metabolite hmdb:HMDB0000108
ERBB4 GeneProduct ensembl:ENSG00000178568
MIR143 GeneProduct ensembl:ENSG00000284182
KLF2 GeneProduct ensembl:ENSG00000127528
CXCL12 GeneProduct ensembl:ENSG00000107562
Prolactin GeneProduct ensembl:ENSG00000172179
RGS16 GeneProduct ensembl:ENSG00000143333
C-Myb GeneProduct ensembl:ENSG00000118513
hsa-miR-145-5p GeneProduct mirbase.mature:MIMAT0000437

References

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  3. Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection. Zernecke A, Bidzhekov K, Noels H, Shagdarsuren E, Gan L, Denecke B, et al. Sci Signal. 2009 Dec 8;2(100):ra81. PubMed Europe PMC Scholia
  4. Secreted monocytic miR-150 enhances targeted endothelial cell migration. Zhang Y, Liu D, Chen X, Li J, Li L, Bian Z, et al. Mol Cell. 2010 Jul 9;39(1):133–44. PubMed Europe PMC Scholia
  5. Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Hergenreider E, Heydt S, Tréguer K, Boettger T, Horrevoets AJG, Zeiher AM, et al. Nat Cell Biol. 2012 Feb 12;14(3):249–56. PubMed Europe PMC Scholia
  6. Mechanism of TNF-α autocrine effects in hypoxic cardiomyocytes: initiated by hypoxia inducible factor 1α, presented by exosomes. Yu X, Deng L, Wang D, Li N, Chen X, Cheng X, et al. J Mol Cell Cardiol. 2012 Dec;53(6):848–57. PubMed Europe PMC Scholia
  7. Cardiac myocyte exosomes: stability, HSP60, and proteomics. Malik ZA, Kott KS, Poe AJ, Kuo T, Chen L, Ferrara KW, et al. Am J Physiol Heart Circ Physiol. 2013 Apr 1;304(7):H954-65. PubMed Europe PMC Scholia
  8. MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy. Halkein J, Tabruyn SP, Ricke-Hoch M, Haghikia A, Nguyen NQN, Scherr M, et al. J Clin Invest. 2013 May;123(5):2143–54. PubMed Europe PMC Scholia
  9. Extracellular Vesicles in Heart Disease: Excitement for the Future ? Danielson KM, Das S. Exosomes Microvesicles. 2014;2(1):10.5772/58390. PubMed Europe PMC Scholia