Modified nucleosides derived from tRNA as urinary cancer markers (WP4485)

Homo sapiens

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Modified nucleosides which are primarily derived from tRNA are urinary biomarkers for various types of cancer, such as breast, colon, liver and lung cancer. This pathway provides an overview of these biomarkers, linked to literature and (if know) the mode of modification.

Authors

Denise Slenter , Friederike Ehrhart , Eric Weitz , Finterly Hu , and Martina Summer-Kutmon

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

disease pathway tRNA decay pathway cancer pathway

Disease Ontology

cancer

Participants

Label Type Compact URI Comment
3-methyluridine Metabolite wikidata:Q15632769 Breast cancer marker
2-methylguanosine Metabolite wikidata:Q1419713 Breast cancer marker
Uridine Metabolite wikidata:Q422573
N2,N2,7-trimethylguanosine Metabolite cas:40027-70-1 Breast cancer marker
(N)4-acetylcytidine Metabolite wikidata:Q20890503 Breast cancer marker
N6-methyladenosine Metabolite wikidata:Q6951996 Breast cancer marker
Guanosine Metabolite wikidata:Q422462
Inosine Metabolite wikidata:Q422564 Hepatocellular carcinoma (HCC) marker
7-methylguanosine Metabolite wikidata:Q4642879 Breast cancer marker
N6-succinyladenosine Metabolite wikidata:Q27139416 Breast cancer marker
Pseudouridine Metabolite wikidata:Q420445 Breast cancer marker
1-methylinosine Metabolite wikidata:Q27109107 Breast cancer marker
Cytidine Metabolite wikidata:Q422538 Hepatocellular carcinoma (HCC) marker
1-methylguanosine Metabolite wikidata:Q161647 Breast cancer marker
N2-N2-dimethyl-guanosine Metabolite wikidata:Q27109160 Breast cancer marker
Adenosine Metabolite wikidata:Q190012 Breast cancer marker
Hepatocellular carcinoma (HCC) marker
1-methyl-adenosine Metabolite wikidata:Q161643 Breast cancer marker
8-hydroxy-2'-deoxyguanosine Metabolite wikidata:Q270154
5'-methylthioadenosine Metabolite wikidata:Q3599216 Breast cancer marker
tRNA GeneProduct wikidata:Q201448

References

  1. Detection of urinary modified nucleosides by a bulk acoustic wave MIP sensor – Results and future work. Agrofoglio LA, Krstulja A, De Schutter C, Favetta P, Delépée R, Roy V, et al. IRBM [Internet]. 2014 Apr;35(2):66–71. Available from: http://dx.doi.org/10.1016/j.irbm.2014.02.009 DOI Scholia
  2. Urinary excretion of modified nucleosides as biological marker of RNA turnover in patients with cancer and AIDS. Nakano K, Nakao T, Schram KH, Hammargren WM, McClure TD, Katz M, et al. Clin Chim Acta. 1993 Sep 30;218(2):169–83. PubMed Europe PMC Scholia
  3. Urinary excretion of modified nucleosides as biological marker of RNA turnover in patients with cancer and AIDS. Nakano K, Nakao T, Schram KH, Hammargren WM, McClure TD, Katz M, et al. Clin Chim Acta. 1993 Sep 30;218(2):169–83. PubMed Europe PMC Scholia
  4. Urinary excretion of pseudouridine and prognosis of patients with malignant lymphoma. Rasmuson T, Björk GR. Acta Oncol. 1995;34(1):61–7. PubMed Europe PMC Scholia
  5. Clinical significance and prognostic value of urinary nucleosides in breast cancer patients. Zheng YF, Kong HW, Xiong JH, Lv S, Xu GW. Clin Biochem. 2005 Jan;38(1):24–30. PubMed Europe PMC Scholia
  6. Metabonomics in cancer diagnosis: mass spectrometry-based profiling of urinary nucleosides from breast cancer patients. Frickenschmidt A, Frohlich H, Bullinger D, Zell A, Laufer S, Gleiter CH, et al. Biomarkers. 2008 Jun;13(4):435–49. PubMed Europe PMC Scholia
  7. Evaluation of urinary nucleosides in breast cancer patients before and after tumor removal. Cho SH, Choi MH, Lee WY, Chung BC. Clin Biochem. 2009 Apr;42(6):540–3. PubMed Europe PMC Scholia
  8. Analysis of urinary nucleosides as helper tumor markers in hepatocellular carcinoma diagnosis. Jeng LB, Lo WY, Hsu WY, Lin WD, Lin CT, Lai CC, et al. Rapid Commun Mass Spectrom. 2009 Jun;23(11):1543–9. PubMed Europe PMC Scholia