Leptin-insulin signaling overlap (WP3935)
Homo sapiens
Overlap of cellular insulin and leptin signaling. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3935 CPTAC Assay Portal]
Authors
Kristina Hanspers , Eric Weitz , and Martina Summer-KutmonActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
insulin signaling pathway leptin system pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| PIP2 | Metabolite | chebi:18348 | |
| PIP3 | Metabolite | chebi:16618 | |
| JAK2 | GeneProduct | ensembl:ENSG00000096968 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16452 |
| PDPK1 | GeneProduct | ensembl:ENSG00000140992 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18607 |
| LEPR | GeneProduct | ensembl:ENSG00000116678 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16847 |
| SOCS3 | GeneProduct | ensembl:ENSG00000184557 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12702 |
| STAT3 | GeneProduct | ensembl:ENSG00000168610 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20848 |
| PIK3R3 | GeneProduct | ensembl:ENSG00000117461 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028698 |
| AKT1 | GeneProduct | ensembl:ENSG00000142208 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11651 |
| SOCS2 | GeneProduct | ensembl:ENSG00000120833 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:216233 |
| PIK3CG | GeneProduct | ensembl:ENSG00000105851 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020573 |
| INSR | GeneProduct | ensembl:ENSG00000171105 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16337 |
| SOCS1 | GeneProduct | ensembl:ENSG00000185338 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12703 |
| INS | GeneProduct | ensembl:ENSG00000254647 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16333 |
| JAK2 | GeneProduct | ensembl:ENSG00000096968 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16452 |
| DGKZ | GeneProduct | ensembl:ENSG00000149091 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000040479 |
| STAT3 | GeneProduct | ensembl:ENSG00000168610 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20848 |
| LEP | GeneProduct | ensembl:ENSG00000174697 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P41160 |
| IRS1 | GeneProduct | ensembl:ENSG00000169047 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16367 |
| PIK3CG | GeneProduct | ensembl:ENSG00000105851 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020573 |
| IRS2 | GeneProduct | ensembl:ENSG00000185950 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:384783 |
| JAK2 | GeneProduct | ensembl:ENSG00000096968 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16452 |
| STAT3 | GeneProduct | ensembl:ENSG00000168610 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20848 |
| IRS4 | GeneProduct | ensembl:ENSG00000133124 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16370 |
References
- Activation of downstream signals by the long form of the leptin receptor. Banks AS, Davis SM, Bates SH, Myers MG Jr. J Biol Chem. 2000 May 12;275(19):14563–72. PubMed Europe PMC Scholia