Leptin-insulin signaling overlap (WP3935)

Homo sapiens

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Overlap of cellular insulin and leptin signaling. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3935 CPTAC Assay Portal]

Authors

Kristina Hanspers , Eric Weitz , and Martina Summer-Kutmon

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

insulin signaling pathway leptin system pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
PIP2 Metabolite chebi:18348
PIP3 Metabolite chebi:16618
JAK2 GeneProduct ensembl:ENSG00000096968 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16452
PDPK1 GeneProduct ensembl:ENSG00000140992 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18607
LEPR GeneProduct ensembl:ENSG00000116678 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16847
SOCS3 GeneProduct ensembl:ENSG00000184557 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12702
STAT3 GeneProduct ensembl:ENSG00000168610 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20848
PIK3R3 GeneProduct ensembl:ENSG00000117461 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028698
AKT1 GeneProduct ensembl:ENSG00000142208 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11651
SOCS2 GeneProduct ensembl:ENSG00000120833 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:216233
PIK3CG GeneProduct ensembl:ENSG00000105851 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020573
INSR GeneProduct ensembl:ENSG00000171105 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16337
SOCS1 GeneProduct ensembl:ENSG00000185338 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12703
INS GeneProduct ensembl:ENSG00000254647 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16333
DGKZ GeneProduct ensembl:ENSG00000149091 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000040479
LEP GeneProduct ensembl:ENSG00000174697 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P41160
IRS1 GeneProduct ensembl:ENSG00000169047 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16367
IRS2 GeneProduct ensembl:ENSG00000185950 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:384783
IRS4 GeneProduct ensembl:ENSG00000133124 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16370

References

  1. Activation of downstream signals by the long form of the leptin receptor. Banks AS, Davis SM, Bates SH, Myers MG Jr. J Biol Chem. 2000 May 12;275(19):14563–72. PubMed Europe PMC Scholia