Hematopoietic stem cell differentiation (WP2849)
Homo sapiens
Growth factors and miRNA regulating differentiation of hematopoietic stem cells (HSC) to various blood-related cell types. Note that myeloblasts branch off separately from erythrocytes and megakaryocytes. Adapted from an open access image attributed to ZooFari and Mikael Häggström (http://en.wikipedia.org/wiki/User:Mikael_H%C3%A4ggstr%C3%B6m/Gallery#Medical_collaborations) and augmented from literature and NHLBI Progenitor Cell Biology Consortium (PCBC) collaborators.
Authors
Alex Pico , Beverly Torok-Storb , Nathan Salomonis , Danie Kuppers , Jiyoon Noh , Xiuli Sim , Deborah L French , Jun Seita , Kristina Hanspers , Friederike Ehrhart , Martina Summer-Kutmon , William Roth , and Eric WeitzActivity
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Cited In
- The Biological Interaction of SARS-CoV-2 Infection and Osteoporosis: A Preliminary Study (2022).
- DNA methylation of ARHGAP30 is negatively associated with ARHGAP30 expression in lung adenocarcinoma, which reduces tumor immunity and is detrimental to patient survival (2021).
- Bioinformatics and system biology approach to identify the influences of SARS-CoV-2 infections to idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease patients (2021).
- Hematopoietic stem-cell senescence and myocardial repair - Coronary artery disease genotype/phenotype analysis of post-MI myocardial regeneration response induced by CABG/CD133+ bone marrow hematopoietic stem cell treatment in RCT PERFECT Phase 3 (2020).
- Systems biology approach reveals a common molecular basis for COVID-19 and non-alcoholic fatty liver disease (NAFLD) (2022).
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Organisms
Homo sapiensCommunities
Annotations
Cell Type Ontology
monocyte erythrocyte myeloblast basophil peripheral blood stem cell megakaryocyte common myeloid progenitor platelet hematopoietic stem cell neutrophil eosinophilPathway Ontology
Interleukin mediated signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| TENX | GeneProduct | uniprot:P22105 | |
| RHOH | GeneProduct | uniprot:Q15669 | |
| NFATC2 | GeneProduct | ensembl:ENSG00000101096 | |
| LEF1 | GeneProduct | uniprot:Q9UJU2 | |
| LMO2 | GeneProduct | ensembl:ENSG00000135363 | |
| FOS | GeneProduct | ensembl:ENSG00000170345 | |
| PIM1 | GeneProduct | uniprot:P11309 | |
| ZNF835 | GeneProduct | uniprot:Q9Y2P0 | |
| CSF1 | GeneProduct | ensembl:ENSG00000184371 | |
| CD34 | GeneProduct | uniprot:P28906 | |
| GATA2 | GeneProduct | uniprot:P23769 | |
| FOSB | GeneProduct | uniprot:P53539 | |
| HMGN5 | GeneProduct | uniprot:P82970 | |
| IRF5 | GeneProduct | uniprot:Q13568 | |
| SPI1 | GeneProduct | ensembl:ENSG00000066336 | |
| THB | GeneProduct | uniprot:P10828 | |
| IKZF1 | GeneProduct | ensembl:ENSG00000185811 | |
| CSF3 | GeneProduct | ensembl:ENSG00000108342 | |
| CBFA2T3 | GeneProduct | ensembl:ENSG00000129993 | |
| MYB | GeneProduct | ensembl:ENSG00000118513 | |
| T3JAM | GeneProduct | uniprot:Q9Y228 | |
| NCKAP1L | GeneProduct | ensembl:ENSG00000123338 | |
| KLF1 | GeneProduct | ensembl:ENSG00000105610 | |
| VAV1 | GeneProduct | ensembl:ENSG00000141968 | |
| C2TA | GeneProduct | uniprot:P33076 | |
| TRIM29 | GeneProduct | ensembl:ENSG00000137699 | |
| STAT5A | GeneProduct | ensembl:ENSG00000126561 | |
| KCNH2 | GeneProduct | ensembl:ENSG00000055118 | |
| S14L2 | GeneProduct | uniprot:O76054 | |
| LYL1 | GeneProduct | ensembl:ENSG00000104903 | |
| CDH1 | GeneProduct | uniprot:CDH1 | |
| IL5 | GeneProduct | ensembl:ENSG00000113525 | |
| HES6 | GeneProduct | uniprot:Q96HZ4 | |
| MUC1 | GeneProduct | uniprot:P15941 | |
| LMO2 | GeneProduct | uniprot:LMO2 | |
| GATA1 | GeneProduct | ensembl:ENSG00000102145 | |
| RUN1T1 | GeneProduct | uniprot:RUN1T1 | |
| PBX1 | GeneProduct | uniprot:PBX1 | |
| HLF | GeneProduct | uniprot:HLF | |
| PRDM5 | GeneProduct | uniprot:PRDM5 | |
| ZFP37 | GeneProduct | uniprot:ZFP37 | |
| SCF | GeneProduct | ensembl:ENSG00000049130 | |
| TPO | GeneProduct | ensembl:ENSG00000115705 | |
| IL3 | GeneProduct | ensembl:ENSG00000164399 | |
| EPO | GeneProduct | ensembl:ENSG00000130427 | |
| IL6 | GeneProduct | ensembl:ENSG00000136244 | |
| IL1A | GeneProduct | ensembl:ENSG00000115008 | |
| CSF2 | GeneProduct | ensembl:ENSG00000164400 | |
| IL1B | GeneProduct | ensembl:ENSG00000125538 | |
| CXCR4 | GeneProduct | ensembl:ENSG00000121966 | |
| MXI1 | GeneProduct | ensembl:ENSG00000119950 | |
| RIOK3 | GeneProduct | ensembl:ENSG00000101782 | |
| ALK4 | GeneProduct | ensembl:ENSG00000135503 | |
| MIR15A | GeneProduct | ensembl:ENSG00000283785 | |
| MIR16-1 | GeneProduct | ensembl:ENSG00000208006 | |
| ABO | GeneProduct | ensembl:ENSG00000175164 | |
| CD41 | GeneProduct | ensembl:ENSG00000005961 | |
| CD42 | GeneProduct | ensembl:ENSG00000169704 | |
| CD235a | GeneProduct | ensembl:ENSG00000170180 | |
| RUNX1 | GeneProduct | ensembl:ENSG00000159216 | |
| NOTCH1 | GeneProduct | ensembl:ENSG00000148400 | |
| MIR223 | GeneProduct | ensembl:ENSG00000284567 | |
| FLI1 | GeneProduct | ensembl:ENSG00000151702 | |
| GATA2 | GeneProduct | ensembl:ENSG00000179348 | |
| NFE2 | GeneProduct | ensembl:ENSG00000123405 | |
| CD61 | GeneProduct | ncbigene:3690 | |
| LOXL3 | GeneProduct | uniprot:LOXL3 | |
| TXK | GeneProduct | uniprot:TXK | |
| GATA5 | GeneProduct | uniprot:GATA5 | |
| WNT11 | GeneProduct | uniprot:WNT11 | |
| HEXIM1 | GeneProduct | uniprot:HEXIM1 | |
| ZGLP1 | GeneProduct | uniprot:ZGLP1 | |
| EGF | GeneProduct | uniprot:EGF | |
| TGFB1 | GeneProduct | uniprot:TGFB1 | |
| LBX2 | GeneProduct | uniprot:LBX2 | |
| ELF1 | GeneProduct | uniprot:ELF1 | |
| ZNF792 | GeneProduct | uniprot:ZNF792 | |
| RCAN1 | GeneProduct | uniprot:RCAN1 | |
| FLI1 | GeneProduct | uniprot:FLI1 | |
| HEXIM2 | GeneProduct | uniprot:HEXIM2 | |
| NLK | GeneProduct | uniprot:NLK | |
| MED12L | GeneProduct | uniprot:MED12L | |
| ZNF789 | GeneProduct | uniprot:ZNF789 | |
| F2R | GeneProduct | uniprot:F2R | |
| PADI4 | GeneProduct | uniprot:PADI4 | |
| MEF2C | GeneProduct | uniprot:MEF2C | |
| CRLF3 | GeneProduct | uniprot:CRLF3 | |
| PIM2 | GeneProduct | uniprot:PIM2 |
References
- The role of micro-ribonucleic acids in normal hematopoiesis and leukemic T-lymphogenesis. Slavov SN, Gimenes Teixeira HL, Rego EM. Braz J Med Biol Res. 2010 Jul;43(7):619–26. PubMed Europe PMC Scholia
- MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment. Zhang L, Sankaran VG, Lodish HF. Leukemia. 2012 Nov;26(11):2310–6. PubMed Europe PMC Scholia
- Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors. Riddell J, Gazit R, Garrison BS, Guo G, Saadatpour A, Mandal PK, et al. Cell. 2014 Apr 24;157(3):549–64. PubMed Europe PMC Scholia