Circadian rhythm genes (WP3594)
Homo sapiens
This is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rhythm" annotation (taxon = homo sapiens). According to supplementary information they were clustered in major (neurotransmitters, hormons, appetite regulation and immune system) and minor groups. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3594 CPTAC Assay Portal]
Authors
Friederike Ehrhart , Martina Summer-Kutmon , Daniela Digles , Kristina Hanspers , Denise Slenter , and Eric WeitzActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
regulatory pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| NPY2R | GeneProduct | uniprot:P49146 | |
| JUN | GeneProduct | uniprot:P05412 | |
| PAX4 | GeneProduct | uniprot:O43316 | |
| CRX | GeneProduct | uniprot:O43186 | |
| NPS | GeneProduct | uniprot:P0C0P6 | |
| ARNT2 | GeneProduct | uniprot:Q9HBZ2 | |
| ADA | GeneProduct | uniprot:P00813 | |
| CIPC | GeneProduct | uniprot:G3V5J4 | |
| DRD3 | GeneProduct | uniprot:P35462 | |
| CIPC | GeneProduct | uniprot:G3V3Y7 | |
| FAS | GeneProduct | uniprot:P25445 | |
| TH | GeneProduct | uniprot:P07101 | |
| CIPC | GeneProduct | uniprot:G3V5Y7 | |
| CIART | GeneProduct | uniprot:Q8N365 | |
| ATOH7 | GeneProduct | uniprot:Q8N100 | |
| PRKG2 | GeneProduct | uniprot:Q13237 | |
| PER1 | GeneProduct | uniprot:O15534 | |
| CLOCK | GeneProduct | uniprot:O15516 | |
| CDK4 | GeneProduct | uniprot:P11802 | |
| DRD4 | GeneProduct | uniprot:P21917 | |
| SFTPC | GeneProduct | uniprot:P11686 | |
| DRD1 | GeneProduct | uniprot:P21728 | |
| EGR1 | GeneProduct | uniprot:P18146 | |
| NCOA2 | GeneProduct | uniprot:Q15596 | |
| TYMS | GeneProduct | uniprot:P04818 | |
| HTR7 | GeneProduct | uniprot:P34969 | |
| ARNTL2 | GeneProduct | uniprot:Q8WYA1 | |
| ADIPOQ | GeneProduct | uniprot:Q15848 | |
| LEP | GeneProduct | uniprot:P41159 | |
| PER3 | GeneProduct | uniprot:Q8TAR6 | |
| SLC9A3 | GeneProduct | uniprot:P48764 | |
| CST3 | GeneProduct | uniprot:P01034 | |
| HDAC3 | GeneProduct | uniprot:O15379 | |
| SLC6A4 | GeneProduct | uniprot:P31645 | |
| CREB1 | GeneProduct | uniprot:P16220 | |
| NCOR1 | GeneProduct | uniprot:O75376 | |
| HOMER1 | GeneProduct | uniprot:Q86YM7 | |
| PER2 | GeneProduct | uniprot:O15055 | |
| KLF10 | GeneProduct | uniprot:Q13118 | |
| AHCY | GeneProduct | uniprot:P23526 | |
| DBP | GeneProduct | uniprot:M0QXP1 | |
| DDX5 | GeneProduct | uniprot:P17844 | |
| SOX14 | GeneProduct | uniprot:O95416 | |
| NAGLU | GeneProduct | uniprot:P54802 | |
| TPH1 | GeneProduct | uniprot:P17752 | |
| ADORA1 | GeneProduct | uniprot:P30542 | |
| NTRK3 | GeneProduct | uniprot:Q16288 | |
| DDC | GeneProduct | uniprot:P20711 | |
| ID4 | GeneProduct | uniprot:P47928 | |
| MTTP | GeneProduct | uniprot:E9PBP6 | |
| KCNH7 | GeneProduct | uniprot:Q9NS40 | |
| PRF1 | GeneProduct | uniprot:P14222 | |
| HCRTR2 | GeneProduct | uniprot:O43614 | |
| HS3ST2 | GeneProduct | uniprot:Q9Y278 | |
| ATF5 | GeneProduct | uniprot:Q9Y2D1 | |
| DBP | GeneProduct | uniprot:Q10586 | |
| MTA1 | GeneProduct | uniprot:Q13330 | |
| NR1H3 | GeneProduct | uniprot:Q13133 | |
| PRKAA1 | GeneProduct | uniprot:Q13131 | |
| RBM4 | GeneProduct | uniprot:Q9BWF3 | |
| SREBF1 | GeneProduct | uniprot:P36956 | |
| GFPT1 | GeneProduct | uniprot:Q06210 | |
| RORA | GeneProduct | uniprot:P35398 | |
| KLF9 | GeneProduct | uniprot:Q13886 | |
| DYRK1A | GeneProduct | uniprot:Q13627 | |
| CUL1 | GeneProduct | uniprot:Q13616 | |
| HDAC1 | GeneProduct | uniprot:Q13547 | |
| METTL3 | GeneProduct | uniprot:Q86U44 | |
| ADORA2A | GeneProduct | uniprot:P29274 | |
| IL6 | GeneProduct | uniprot:P05231 | |
| STAR | GeneProduct | uniprot:P49675 | |
| HNF1B | GeneProduct | uniprot:P35680 | |
| ID3 | GeneProduct | uniprot:Q02535 | |
| NPAS2 | GeneProduct | uniprot:Q99743 | |
| SIX3 | GeneProduct | uniprot:O95343 | |
| NR2F6 | GeneProduct | uniprot:P10588 | |
| ARNT | GeneProduct | uniprot:P27540 | |
| CHRNB2 | GeneProduct | uniprot:P17787 | |
| AGRP | GeneProduct | uniprot:O00253 | |
| UTS2R | GeneProduct | uniprot:Q9UKP6 | |
| JUND | GeneProduct | uniprot:P17535 | |
| CLDN4 | GeneProduct | uniprot:O14493 | |
| BTBD9 | GeneProduct | uniprot:Q96Q07 | |
| SETX | GeneProduct | uniprot:Q7Z333 | |
| ADCY1 | GeneProduct | uniprot:Q08828 | |
| KCNMA1 | GeneProduct | uniprot:Q12791 | |
| CREM | GeneProduct | uniprot:Q03060 | |
| DRD2 | GeneProduct | uniprot:P14416 | |
| NTRK1 | GeneProduct | uniprot:P04629 | |
| KCND2 | GeneProduct | uniprot:Q9NZV8 | |
| PRKAA2 | GeneProduct | uniprot:P54646 | |
| OPRL1 | GeneProduct | uniprot:P41146 | |
| PROX1 | GeneProduct | uniprot:Q92786 | |
| TNFRSF11A | GeneProduct | uniprot:Q9Y6Q6 | |
| MAGED1 | GeneProduct | uniprot:Q9Y5V3 | |
| MC3R | GeneProduct | uniprot:P41968 | |
| PTGDS | GeneProduct | uniprot:P41222 | |
| OGT | GeneProduct | uniprot:O15294 | |
| EZH2 | GeneProduct | uniprot:Q15910 | |
| KDM5A | GeneProduct | uniprot:P29375 | |
| HDAC2 | GeneProduct | uniprot:Q92769 | |
| PPP1CC | GeneProduct | uniprot:P36873 | |
| GNA11 | GeneProduct | uniprot:P29992 | |
| NKX2-1 | GeneProduct | uniprot:P43699 | |
| RORB | GeneProduct | uniprot:Q92753 | |
| CCAR2 | GeneProduct | uniprot:Q8N163 | |
| SKP1 | GeneProduct | uniprot:P63208 | |
| PROK2 | GeneProduct | uniprot:Q9HC23 | |
| OPN3 | GeneProduct | uniprot:Q9H1Y3 | |
| SUV39H2 | GeneProduct | uniprot:Q9H5I1 | |
| ATF4 | GeneProduct | uniprot:P18848 | |
| OPN4 | GeneProduct | uniprot:Q9UHM6 | |
| MAGEL2 | GeneProduct | ensembl:ENSG00000254585 | |
| GHRL | GeneProduct | uniprot:Q9UBU3 | |
| FBXL21 | GeneProduct | ensembl:ENSG00000164616 | |
| F7 | GeneProduct | uniprot:P08709 | |
| TIMELESS | GeneProduct | uniprot:Q9UNS1 | |
| USP2 | GeneProduct | uniprot:O75604 | |
| NMS | GeneProduct | uniprot:Q5H8A3 | |
| SFPQ | GeneProduct | uniprot:P23246 | |
| ROCK2 | GeneProduct | uniprot:O75116 | |
| NR1D1 | GeneProduct | uniprot:P20393 | |
| NGFR | GeneProduct | uniprot:P08138 | |
| CRH | GeneProduct | uniprot:P06850 | |
| ARNTL | GeneProduct | uniprot:O00327 | |
| PSPC1 | GeneProduct | uniprot:Q8WXF1 | |
| NPAS2 | GeneProduct | uniprot:Q99743 | |
| PPARGC1A | GeneProduct | uniprot:Q9UBK2 | |
| TP53 | GeneProduct | uniprot:P04637 | |
| SIN3A | GeneProduct | uniprot:Q96ST3 | |
| PRKDC | GeneProduct | uniprot:P78527 | |
| BTRC | GeneProduct | uniprot:Q9Y297 | |
| THRAP3 | GeneProduct | uniprot:Q9Y2W1 | |
| FBXW11 | GeneProduct | uniprot:Q9UKB1 | |
| NOCT | GeneProduct | uniprot:Q9UK39 | |
| RAI1 | GeneProduct | uniprot:Q7Z5J4 | |
| TOP2A | GeneProduct | uniprot:P11388 | |
| TOP1 | GeneProduct | uniprot:P11387 | |
| CHRM1 | GeneProduct | uniprot:P11229 | |
| EP300 | GeneProduct | uniprot:Q09472 | |
| PRKCDBP | GeneProduct | uniprot:Q969G5 | |
| PRKCG | GeneProduct | uniprot:P05129 | |
| SERPINE1 | GeneProduct | uniprot:P05121 | |
| ZFHX3 | GeneProduct | uniprot:Q15911 | |
| NCOA2 | GeneProduct | uniprot:Q15596 | |
| NONO | GeneProduct | uniprot:Q15233 | |
| PROKR1 | GeneProduct | uniprot:Q8TCW9 | |
| ADCY1 | GeneProduct | uniprot:Q08828 | |
| SIRT1 | GeneProduct | uniprot:Q96EB6 | |
| HCRTR1 | GeneProduct | uniprot:O43613 | |
| NFIL3 | GeneProduct | uniprot:Q16649 | |
| AANAT | GeneProduct | uniprot:Q16613 | |
| CARTPT | GeneProduct | uniprot:Q16568 | |
| CRY1 | GeneProduct | uniprot:Q16526 | |
| HNRNPD | GeneProduct | uniprot:Q14103 | |
| GNAQ | GeneProduct | ensembl:ENSG00000156052 | |
| SIK1 | GeneProduct | uniprot:P57059 | |
| GSK3B | GeneProduct | uniprot:P49841 | |
| HCRTR2 | GeneProduct | uniprot:O43614 | |
| HCRTR1 | GeneProduct | uniprot:O43613 | |
| CSNK1E | GeneProduct | uniprot:P49674 | |
| SUV39H1 | GeneProduct | uniprot:O43463 | |
| RELB | GeneProduct | uniprot:Q01201 | |
| HNRNPU | GeneProduct | uniprot:Q00839 | |
| Q59FM5 | GeneProduct | uniprot:Q59FM5 | |
| FBXL3 | GeneProduct | uniprot:Q9UKT7 | |
| NLGN1 | GeneProduct | uniprot:Q8N2Q7 | |
| MTNR1B | GeneProduct | uniprot:P49286 | |
| UBA52 | GeneProduct | uniprot:P62987 | |
| RPS27A | GeneProduct | uniprot:P62979 | |
| PPP1CB | GeneProduct | uniprot:P62140 | |
| PPP1CB | GeneProduct | uniprot:P62140 | |
| PPP1CA | GeneProduct | uniprot:P62136 | |
| GHRH | GeneProduct | uniprot:P01286 | |
| AVP | GeneProduct | uniprot:P01185 | |
| EGR3 | GeneProduct | uniprot:Q06889 | |
| HEBP1 | GeneProduct | uniprot:Q9NRV9 | |
| PPARA | GeneProduct | uniprot:Q07869 | |
| CRTC1 | GeneProduct | uniprot:Q6UUV9 | |
| NRIP1 | GeneProduct | uniprot:P48552 | |
| CSNK1D | GeneProduct | uniprot:P48730 | |
| KMT2A | GeneProduct | uniprot:Q03164 | |
| NR1D2 | GeneProduct | uniprot:Q14995 | |
| RBM4B | GeneProduct | uniprot:Q9BQ04 | |
| MYBBP1A | GeneProduct | uniprot:Q9BQG0 | |
| UBE3A | GeneProduct | uniprot:Q05086 | |
| CIPC | GeneProduct | uniprot:Q9C0C6 | |
| PROKR2 | GeneProduct | uniprot:Q8NFJ6 | |
| ID2 | GeneProduct | uniprot:Q02363 | |
| PTEN | GeneProduct | uniprot:P60484 | |
| DHX9 | GeneProduct | uniprot:Q08211 | |
| MTNR1A | GeneProduct | uniprot:P48039 | |
| NOS2 | GeneProduct | uniprot:P35228 | |
| PHLPP1 | GeneProduct | uniprot:O60346 | |
| UTS2 | GeneProduct | uniprot:O95399 | |
| TPH2 | GeneProduct | uniprot:Q8IWU9 | |
| C1orf51 | GeneProduct | uniprot:Q5TB13 | |
| CIPC | GeneProduct | uniprot:G3V405 | |
| MAPK9 | GeneProduct | uniprot:P45984 | |
| MAPK8 | GeneProduct | uniprot:P45983 | |
| RORC | GeneProduct | uniprot:P51449 | |
| MAPK10 | GeneProduct | uniprot:P53779 | |
| UBC | GeneProduct | uniprot:P0CG48 | |
| PPARG | GeneProduct | uniprot:P37231 | |
| PASD1 | GeneProduct | uniprot:Q8IV76 | |
| CRY2 | GeneProduct | uniprot:Q49AN0 | |
| CPT1A | GeneProduct | uniprot:P50416 | |
| LGR4 | GeneProduct | uniprot:Q9BXB1 | |
| PML | GeneProduct | uniprot:P29590 | |
| PROK1 | GeneProduct | uniprot:P58294 | |
| NAMPT | GeneProduct | uniprot:P43490 | |
| AHR | GeneProduct | uniprot:P35869 | |
| BHLHE41 | GeneProduct | uniprot:Q9C0J9 | |
| PRMT5 | GeneProduct | uniprot:O14744 | |
| BHLHE40 | GeneProduct | uniprot:O14503 | |
| HOMER1 | GeneProduct | uniprot:Q86YM7 | |
| NRIP1 | GeneProduct | uniprot:P48552 | |
| PROKR2 | GeneProduct | uniprot:Q8NFJ6 | |
| C1orf51 | GeneProduct | uniprot:Q5TB13 | |
| AGRP | GeneProduct | uniprot:O00253 | |
| PROKR1 | GeneProduct | uniprot:Q8TCW9 | |
| SIRT1 | GeneProduct | uniprot:Q96EB6 | |
| PROK2 | GeneProduct | uniprot:Q9HC23 | |
| BHLHE41 | GeneProduct | uniprot:Q9C0J9 | |
| PRKAA1 | GeneProduct | uniprot:Q13131 |