AlexanderPico

Molecular pathway for oxidative stress

Integrated breast cancer pathway

Omega-3-fatty acids in senescence

Pathways into methionine and folate cycles

Hallmark of cancer: metastasis and epithelial-to-mesenchymal transition

Fanconi anemia

Type I interferon induction and signaling during SARS-CoV-2 infection

Type 2 papillary renal cell carcinoma

Kallmann syndrome

Pantothenate and coenzyme A biosynthesis

Homocysteine and cysteine interconversion

Threonine biosynthesis

PCSK9-mediated LDL receptor degradation

B cell receptor signaling

Glutamate degradation I

Statin inhibition of cholesterol production

Liver steatosis adverse outcome pathway

Pyruvate dehydrogenase pathway

Dauer formation

Mitochondrial unfolded-protein response

ER stress-unfolded protein response (UPRer)

Heterochronic gene regulation of development

Ascaroside biosynthesis

TOR signaling

Cell division: first embryonic mitosis

Biogenic amine synthesis

Wnt signaling

Metapathway signal transduction

Pentose phosphate metabolism

Hedgehog signaling

Principal pathways of carbon metabolism

AMP-activated protein kinase signaling

Follicle stimulating hormone (FSH) signaling

IL5 signaling

T-cell activation SARS-CoV-2

Irinotecan pathway

T-cell receptor signaling

Estradiol regulation in porto-sinusoidal vascular disease

Insulin signaling

Nonalcoholic fatty liver disease

Clear cell renal cell carcinoma pathways

Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling

Focal adhesion

Glucocorticoid receptor pathway

Androgen receptor signaling

Endoplasmic reticulum stress response in coronavirus infection

HDAC6 interactions in the central nervous system

Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex

PI3K/AKT/mTOR - vitamin D3 signaling

Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling

Pathogenic Escherichia coli infection

Nuclear receptors

Vitamin B12 metabolism

T cell receptor and co-stimulatory signaling

Toll-like receptor signaling

TYROBP causal network in microglia

Ovarian infertility

Serotonin receptor 2 and ELK-SRF/GATA4 signaling

Sudden infant death syndrome (SIDS) susceptibility pathways

NAD+ biosynthetic pathways

HIF1A and PPARG in cardiac hypertropthy

GNAQ pathways in port-wine stain

Calcium regulation in cardiac cells

Macrophage-stimulating protein (MSP) signaling

Activation of NLRP3 inflammasome by SARS-CoV-2

NAD biosynthesis II from tryptophan

MAPK pathway in congenital thyroid cancer

G1 to S cell cycle control

Vitamins A and D - action mechanisms

Imatinib and chronic myeloid leukemia

Thymic stromal lymphopoietin (TSLP) signaling

TP53 network

Docosahexaenoic acid oxylipin metabolism

Major receptors targeted by epinephrine and norepinephrine

Metabolism of alpha-linolenic acid

Blood clotting and drug effects

Translation inhibitors in chronically activated PDGFRA cells

Estrogen receptor pathway

Female steroid hormones in cardiomyocyte energy metabolism

DYRK1A involvement regarding cell proliferation in brain development

Prader-Willi and Angelman syndrome

15q25 copy number variation

5q35 copy number variation

17p13.3 (YWHAE) copy number variation

Affected pathways in Duchenne muscular dystrophy

Lactate shuttle in glial cells

Neurogenesis regulation in the olfactory epithelium

Hippocampal synaptogenesis and neurogenesis

Glucose metabolism in triple-negative breast cancer cells

ALA oxylipin metabolism

Mitochondrial fatty acid oxidation disorders

ACE2 inhibition leads to pulmonary fibrosis

p53 transcriptional gene network

Complement system

EBV LMP1 signaling

Aflatoxin B1 metabolism

Glucuronidation

Estrogen metabolism

Arachidonate epoxygenase / epoxide hydrolase

Oxidative phosphorylation

Interferon type I signaling

Exercise-induced circadian regulation

Complement and coagulation cascades

Wnt/Beta-catenin signaling inhibitors in current and past clinical trials

8p23.1 copy number variation syndrome

1p36 copy number variation syndrome

Octadecanoid formation from linoleic acid

Male steroid hormones in cardiomyocyte energy metabolism

Sebaleic acid formation and metabolism

Lacto series sphingolipid metabolism

Ganglio series sphingolipid metabolism

Pentose phosphate pathway in senescent cells

TCA cycle

Hijack of ubiquitination by SARS-CoV-2

Aerobic glycolysis

ESC pluripotency pathways

Ebstein-Barr virus LMP1 signaling

Aerobic glycolysis - augmented

Biotic stress response gene network

Angiopoietin-like protein 8 regulatory pathway

Dengue-2 interactions with complement and coagulation cascades

Nanomaterial-induced inflammasome activation

Pluripotent stem cell differentiation pathway

Quercetin and Nf-kB / AP-1 induced apoptosis

DNA damage response (only ATM dependent)

Androgen receptor network in prostate cancer

Endothelin pathways

RANKL/RANK signaling

Folic acid network

Nod-like receptor (NLR) signaling pathway

Folic acid network

Nod-like receptor (NLR) signaling pathway

Complement and coagulation cascades

Nod-like receptor (NLR) signaling pathway

Monoamine transport

Vitamin A and carotenoid metabolism

MAPK cascade

FTO obesity variant mechanism

RAC1/PAK1/p38/MMP2 pathway

Statin pathway

Sulfur amino acid biosynthesis

Folate metabolism

Neurotransmitter release in cholinergic motor neurons

Sucrose biosynthesis

Electron transport chain: OXPHOS system in mitochondria

Histidine metabolism

Microtubule cytoskeleton regulation

Hippo signaling regulation

Extracellular vesicle-mediated signaling in recipient cells

Common pathways underlying drug addiction

Estrogen signaling

ErbB signaling

IL26 signaling

G13 signaling

CCL18 signaling

IL2 signaling

Hedgehog signaling

IL10 anti-inflammatory signaling

EGF/EGFR signaling

Fibrin complement receptor 3 signaling

p38 MAPK signaling

Wnt signaling and pluripotency

IL4 signaling

MAPK signaling

Wnt signaling

G protein signaling

Nod-like receptor (NLR) signaling

ATM signaling

Oncostatin M signaling

Corticotropin-releasing hormone signaling

TNF-alpha signaling

Glioblastoma signaling

IL9 signaling

IL17 signaling

IL7 signaling

Prolactin signaling

TNF-related weak inducer of apoptosis (TWEAK) signaling

Thyroid stimulating hormone (TSH) signaling

Triacylglyceride synthesis

H19, Rb-E2F1, and CDK-beta-catenin in colorectal cancer

PI3K-AKT-mTOR signaling and therapeutic opportunities in prostate cancer

Statin pathway

Selenium metabolism and selenoproteins

Sulfur degradation

Lipids measured in liver metastasis from breast cancer

Wnt signaling in kidney disease

MicroRNA for targeting cancer growth and vascularization in glioblastoma

Mecp2 and associated Rett syndrome

Cytokines and inflammatory response

Extrafollicular and follicular B cell activation by SARS-CoV-2

Markers of kidney cell lineage

mRNA vaccine activation of dendritic cell and induction of IFN-1

Poly(glycerol phosphate) wall teichoic acid biosynthesis

Hematopoietic stem cell differentiation

Glial cell differentiation

Mitochondrial complex inhibition leading to liver injury

Gastric acid production

Downregulation of ACE2 by SARS-CoV-2 spike protein

Physiological and pathological hypertrophy of the heart

TCA cycle (aka Krebs or citric acid cycle)

Oxidative stress response

Steroid biosynthesis

Glutathione metabolism

Ciliopathies

Endochondral ossification

Envelope proteins and their potential roles in EDMD physiopathology

DNA damage response

10q11.21q11.23 copy number variation syndrome

Epithelial to mesenchymal transition in colorectal cancer

Photodynamic therapy-induced NF-kB survival signaling

Effects of nitric oxide

N-glycan biosynthesis

DNA replication

Flowering time pathway

Oxytocin signaling

Flowering time pathway

One-carbon metabolism

Thyroxine (thyroid hormone) production

GABA receptor signaling

Host-pathogen interaction of human coronaviruses - interferon induction

TCA cycle nutrient use and invasiveness of ovarian cancer

Irinotecan pathway

Angiotensin II receptor type 1 pathway

Evolocumab mechanism to reduce LDL cholesterol

4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression

Regulation of apoptosis by parathyroid hormone-related protein

Vitamin D metabolism

Endometrial cancer

ACE inhibitor pathway

7-oxo-C and 7-beta-HC pathways

Angiogenesis

Oxysterols derived from cholesterol

NAD metabolism, sirtuins and aging

Gene regulatory network modeling somitogenesis

Histone modifications

Biotin metabolism

Type II diabetes mellitus

Chronic hyperglycemia impairment of neuron function

Parkinson's disease pathway

Ether lipid biosynthesis

Hippo-Merlin signaling dysregulation

MECP2 and associated Rett syndrome

Complement activation

Apoptosis

Codeine and morphine metabolism

BDNF-TrkB signaling

Amyotrophic lateral sclerosis (ALS)

Cholesterol biosynthesis pathway

Apoptosis modulation and signaling

Fructose and mannose metabolism

KCNQ2-related epilepsies

Glycolysis and gluconeogenesis

Alzheimer's disease and miRNA effects

Nucleotide GPCRs

Tryptophan metabolism

Monoamine GPCRs

Regulation of actin cytoskeleton

Notch signaling pathway

Peptide GPCRs

T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection

MYD88 distinct input-output pathway

Canonical and non-canonical Notch signaling

EV release from cardiac cells and their functional effects

Metapathway biotransformation Phase I and II

Interleukin-1 (IL-1) structural pathway

Non-small cell lung cancer

Methionine de novo and salvage pathway

Non-canonical Wnt pathway

Purine metabolism

Cardiac progenitor differentiation

Glycolysis in senescence

Non-homologous end joining

Primary ovarian insufficiency

Pleural mesothelioma

Wnt signaling

Cell cycle

Transcriptional activation by NRF2 in response to phytochemicals

PDGFR-beta pathway

Gibberellin A12 biosynthesis

Alanine and aspartate metabolism

CBD synthetic pathway

D-arginine and D-ornithine metabolism

Osteoblast signaling

Genetic alterations of lung cancer

Nicotine effect on chromaffin cells

Osteoclast signaling

Ergosterol biosynthesis

Comprehensive IL-17A signaling

Aryl hydrocarbon receptor pathway

Integrated cancer pathway

Cori cycle

Mechanisms associated with pluripotency

Folate-alcohol and cancer pathway hypotheses

MicroRNAs in cardiomyocyte hypertrophy

Energy metabolism

miRNA regulation of DNA damage response

Glycine metabolism

AGE/RAGE pathway

Nicotine effect on dopaminergic neurons

Fluoropyrimidine activity

Mitochondrial long chain fatty acid beta-oxidation

Parkinson's disease

Target of rapamycin signaling

Serotonin transporter activity

VEGFA-VEGFR2 signaling

Apoptosis modulation by HSP70

Osteoblast signaling

Notch signaling

Small ligand GPCRs

Response regulator aspartate phosphatase interactions

mRNA processing

Eukaryotic transcription initiation

Fas ligand pathway and stress induction of heat shock proteins

Nuclear receptors in lipid metabolism and toxicity

Myometrial relaxation and contraction pathways

S1P receptor signal transduction

Osteopontin signaling

Homologous recombination

Integrin-mediated cell adhesion

Bone morphogenic protein signaling and regulation

TGF-beta receptor signaling

Biogenic amine synthesis

Hypertrophy model

Sulfation biotransformation reaction

Glucose homeostasis

Flower development

Glycogen synthesis and degradation

Prostaglandin synthesis and regulation

Elongation of (very) long chain fatty acids

Bacterial ceramide synthesis

Serotonin receptor 4/6/7 and NR3C signaling

Serotonin HTR1 group and FOS pathway

Serotonin transporter activity

Serotonin receptor 4/6/7 and NR3C signaling

Serotonin receptor 2 and ELK-SRF / GATA4 signaling

Serotonin receptor 2 and STAT3 signaling

Serotonin receptor 2 and STAT3 signaling

IL-9 signaling pathway

Amino acid conjugation of benzoic acid

IL-6 signaling pathway

Metabolic pathways of fibroblasts

Cysteine biosynthesis from homoserine

Meiotic recombination genes

Osteoclast signaling

GPCRs, class A rhodopsin-like

Nuclear factor, erythroid-derived 2, like 2 signaling pathway

Metapathway biotransformation

Colanic acid building blocks biosynthesis

Fatty acid biosynthesis

Fatty acid biosynthesis

Fatty acid biosynthesis

Fatty acid biosynthesis

Fatty acid biosynthesis

Fatty acid biosynthesis

Mevalonate pathway

Glycerol teichoic acid biosynthesis

Catecholamine synthesis

Oxidative stress and redox pathway

Metabolism of tetrahydrocannabinol (THC)

Primary focal segmental glomerulosclerosis (FSGS)

Primary carbon metabolism

Carbon assimilation C4 pathway

Oxidation by cytochrome P450

Oxidation by cytochrome P450

mRNA processing

Ureide biosynthesis

Heme biosynthesis

TCA cycle in senescence

Pregnane X receptor pathway

Eicosanoid synthesis

Selenium micronutrient network

Fatty acid beta-oxidation

Retinol metabolism

Retinol metabolism

Triacylglyceride synthesis

mRNA processing

Myometrial relaxation and contraction pathways

Myometrial relaxation and contraction pathways

Semaphorin interactions

mRNA processing

mRNA processing

Myometrial relaxation and contraction pathways

Notch signaling pathway

mRNA processing

mRNA Processing

TLR4 signaling and tolerance

PDGF pathway

Retinoblastoma gene in cancer

Glycolysis and gluconeogenesis

Allograft rejection

Microglia pathogen phagocytosis pathway

Regulation of actin cytoskeleton

ID signaling pathway

ID signaling pathway

ID signaling pathway

TGF-beta signaling pathway

ID signaling pathway

Melatonin metabolism and effects

Aryl hydrocarbon receptor pathway

SARS-CoV-2 and COVID-19 pathway

BDNF pathway

Photodynamic therapy-induced AP-1 survival signaling

Long-day flowering time pathway

Cell differentiation - index

Spinal cord injury

Parkin-ubiquitin proteasomal system pathway

Vitamin D receptor pathway

Nod-like receptor (NLR) signaling pathway

Nicotine metabolism in liver cells

Tryptophan metabolism

Role of carnosine in muscle contraction

Host-pathogen interaction of human coronaviruses - MAPK signaling

Primary focal segmental glomerulosclerosis (FSGS)

Arrhythmogenic right ventricular cardiomyopathy

EGF/EGFR signaling pathway

NAD+ metabolism

miR-222 in exercise-induced cardiac growth

Flowering time pathway

Metabolic reprogramming in colon cancer

Nodal signaling pathway

Glycogen metabolism

Flavonoid pathway

Heterchronic control of molting

FGF signaling pathway

Folate biosynthesis

Wnt signaling pathway and pluripotency

EGFR1 signaling pathway

Eukaryotic transcription initiation

Exercise-induced circadian regulation

Canonical NF-kB pathway

Osteoclast signaling

Kit receptor signaling pathway

IL-6 signaling pathway

Aryl hydrocarbon receptor pathway

Glycogen metabolism

Electron transport chain

Delta-Notch signaling pathway

Neural crest differentiation

GPCRs, orphan

Endochondral ossification

Delta-Notch signaling pathway

Hedgehog signaling pathway

Methylation pathways

Catalytic cycle of mammalian flavin-containing monooxygenases (FMOs)

DNA mismatch repair

GPCRs, class C metabotropic glutamate, pheromone

Neural crest cell migration in cancer

Neural crest cell migration during development

GPCRs, class A rhodopsin-like

Acrylamide biotransformation and exposure biomarkers

Tgif disruption of Shh signaling

lncRNA-mediated mechanisms of therapeutic resistance

Interactions between LOXL4 and oxidative stress pathway

GPCRs, class B secretin-like

Constitutive androstane receptor pathway

Hair follicle development: organogenesis - part 2 of 3

Cardiac hypertrophic response

Diclofenac metabolic pathway

Gastric cancer network 2

Gastric cancer network 1

Fatty acid omega-oxidation

SRF and miRs in smooth muscle differentiation and proliferation

GPCRs, other

Cytokines and inflammatory response

Methylation pathways

Nuclear receptors in lipid metabolism and toxicity

Glycogen metabolism

Nuclear receptors

Delta-Notch signaling pathway

Hedgehog signaling pathway

Kit receptor signaling pathway

EGFR1 signaling pathway

Fatty acid omega-oxidation

Globo sphingolipid metabolism

Aryl hydrocarbon receptor

ATM signaling pathway

Interleukin-11 signaling pathway

AMPK signaling

Folate-alcohol and cancer pathway

Isoprenoid precursor biosynthesis in Pf apicoplasts

NAD biosynthesis I from aspartate

Osteoblast signaling

Beta-alanine biosynthesis

Carotenoid biosynthesis

Ganglio sphingolipid metabolism

Glycogen metabolism

Nuclear receptors

Statin pathway

Hedgehog signaling pathway

Kit receptor signaling pathway

Electron transport chain

Cytokines and inflammatory response

EGFR1 signaling pathway

Glycogen metabolism

Nuclear receptors

Endochondral ossification

Notch signaling pathway

TGF-beta signaling pathway

B cell receptor signaling pathway

Hedgehog signaling pathway

Electron transport chain

Glycolysis and gluconeogenesis

MAPK signaling pathway

Methionine degradation

Tryptophan degradation

Starch and cellulose biosynthesis

Nuclear receptors

Inhibitor of DNA binding (ID) signaling pathway

Hedgehog signaling pathway

Kit receptor signaling pathway

Triacylglycerol biosynthesis

Biosynthesis of gamma-aminobutyric acid (GABA) by polyamine oxidation

Chlorophyll b degradation

Flower development: initiation

Glycogen metabolism

Delta-Notch signaling pathway

Calcium regulation in cardiac cells

EGFR1 signaling pathway

Polyol pathway

GPR40 pathway

miRNA biogenesis

Exercise-induced circadian regulation

Nod-like receptor (NLR) signaling pathway

Hedgehog signaling pathway

Complement and coagulation cascades

Hedgehog signaling pathway

Osteoclast

Cytoplasmic ribosomal proteins

Lipid droplet metabolism

Thick ascending limb transporters

Proximal tubule transporters

Glial cell differentiation

mir219 in oligodendrocyte differentiation and myelination

Nuclear receptors

Glycogen metabolism

Kit receptor signaling pathway

Statin pathway

Homologous recombination

Glycogen metabolism

Glycolysis and gluconeogenesis

Estrogen signaling

Synthesis and degradation of ketone bodies

Biogenic amine synthesis

Microglia pathogen phagocytosis pathway

Glycolysis and gluconeogenesis

MicroRNAs in cardiomyocyte hypertrophy

Biogenic amine synthesis

Electron transport chain

p38 MAPK signaling pathway

Integrin-mediated cell adhesion

p38 Mapk signaling pathway

Tyrobp causal network in microglia

Glutathione and one-carbon metabolism

Host-pathogen interaction of human coronaviruses - apoptosis

Host-pathogen interaction of human coronaviruses - autophagy

One-carbon metabolism

Retinoblastoma gene in cancer

Toll-like receptor signaling

Farnesoid X receptor pathway

PPAR-alpha pathway

Liver X receptor pathway

Endoderm differentiation

Androgen receptor signaling pathway

Kit receptor signaling pathway

Androgen receptor signaling pathway

ID signaling pathway

Androgen receptor signaling pathway

Wnt Signaling Pathway and Pluripotency

Ptf1a related regulatory pathway

Regulation of Pgc1a expression by a Gsk3b-Tfeb signaling axis in skeletal muscle

Influenza A virus infection

Hexoses metabolism in proximal tubules

Corticotropin-releasing hormone

mir-193a and MVP in colon cancer metastasis

Transcriptional cascade regulating adipogenesis

Macrophage markers

Angiotensin II signaling (acute) in thick ascending limbs

Gonadotropin-releasing hormone (GnRH) signaling

Cocaine metabolism

Gluconeogenesis

Cadmium and glutathione

Fatty acid oxidation

PPAR signaling pathway

Lycopene biosynthesis

NRF2 pathway

Novel intracellular components of RIG-I-like receptor pathway

Benzo(a)pyrene metabolism

Arylamine metabolism

Estrogen signaling pathway

Acetaminophen synthesis

NAD salvage pathway III

NAD salvage pathway II

NAD salvage pathway I

Adipogenesis

Biosynthesis and regulation of nematode bile acids

Estrogen metabolism

Chemokine signaling pathway

Hfe effect on hepcidin production

Apoptosis

Lipoic acid metabolism

Ascorbate and aldarate metabolism

Brain derived neurotrophic factor

Hfe effect on hepcidin production

Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling

Nuclear Receptors

eIF5A regulation in response to inhibition of the nuclear export system

Gene regulatory network modelling somitogenesis

Gastric cancer network 2

Glycolysis

Gene regulatory network modelling somitogenesis

Metapathway biotransformation

Histone modifications

Type II interferon signaling (IFNG)